We encourage collaboration between labs to foster the commitment of several groups toward a solution. Collaboration leads to success and to personal growth.
Members A-G
Barth, Patrick - Uncovering and designing membrane protein structure and function
- Potassium channel modulators for the treatment of autoimmune diseases
- Analysis of metabolite-mediated synaptic transmission
Cao, Wei - Study of neuroinflammation related to degenerative diseases, esp. Alzheimer’s disease
Catic, Andre - Studying regulators of transcript and transcription factor turnover in stem and cancer cells
- Identification of drug targets for urothelial cancer stem cells
- Screening anti-tumor effects of Saponin from Chinese medicines
- Targeting palmitoyl transferase to selectively block Ras localization to the plasma membrane
- Novel disease gene identification and targeted therapy of inherited human retinal diseases
- Discovery of small molecule modulators of orphan nuclear receptors
- Small molecules that neutralize the toxic effects of expanded repeat RNA expressed from mutant myotonic dystrophy alleles
- A2 protein: Novel treatments for systemic inflammation
- Pharmacologic agonism of the Th-1 immune response
Deng, Lisheng - Development of epigenetic small-molecular modulators against tumor and viruses
- Probing small molecule libraries for RAI1 induced gene
expression
- Development of inhibitors of enteric viruses
Ferreon, Allan - Protein Misfolding and Aggregation at Single-Molecule Resolution
Ferreon, Josephine - Allostery in Intrinsically Disordered Hub Proteins
- Identification of small molecule inhibitors of human NCOA6 activity
- Synthetic agonists in controlling circadian homeostasis of metabolism and cell proliferation in vivo
Fuqua, Suzanne - Therapeutic targeting of the Rho signaling pathway in hormone-resistant breast cancer
- Growth hormone secretagogues in the treatment of cancer cachexia
Garcia, Thomas - Small molecules for male contraception
Members H-L
- The ERβ/SRC-1 isoform complex drives endometriosis progression
- Binding of Integrin to different registers of the heterotrimeric mimics of type I collagen.
- Discovery of drugs that affect endometriotic cell function
- Tissue-specific modulators of BK potassium channels
- Small molecule control of viral gene therapy and infection
Hyser, Joseph - Pathophysiology of intestinal fluid secretion during diarrhea
Jankowsky, Joanna - Proline mutants for amyloid inhibition
- Small molecule inhibitor of SPP1 in cigarette smoke-induced emphysema
- Targeting cGMP-dependent protein kinase for developing hypertension drugs
- Small molecule therapies to perturb host-pathogen interactions and promote cellular health
- Novel noradrenergic blockers and copper chelators for cocaine and methamphetamine dependence
- Role of FKBP10 as a regulator of Lysyl hydroxylase 2 biochemical activity
- Developing chemical probes to interrogate Hsp90 molecular chaperone function for structure-based drug design
- Small molecule treatments for transitional cell carcinoma, non-muscle invasive tumors and urothelial carcinomas of the bladder
- Small molecule treatments for transitional cell carcinoma, non-muscle invasive tumors and urothelial carcinomas of the bladder
- Overcoming treatment resistance in breast cancer and small molecule inhibitors of Stat
Li, Feng - Application of drug metabolism and pharmacokinetics in drug development
- Computational tools for gene function predictions and molecular network analyses to identify potential drug screening targets and assays.
- Averting the oncogenic functions of mutant p53
- Developing novel coactivator small molecule inhibitors as drugs to treat cancers and metabolic conditions and as contraceptive agents
- Small molecule therapeutics and biomarkers of endometrial disorders
Members M-P
MacKenzie, Kevin - Ligand binding and structure-activity relationship by NMR
- Ligand binding of TLX
- Application of computational and OMICS approaches to improve both the diagnosis and prognosis of pediatric cancer patients
- High throughput microscopy-based screening of nuclear receptor functions
Mansouri, David - Small-molecule antimicrobics including those with novel mechanism of action
- Search for small molecules inhibiting the activation of the outlaw androgen receptor (AR) variant AR-V7 in castration-resistant prostate cancer
- Small molecules for TGFbeta signaling, cancer, and male contraception
- Tail-treatment of B-CLL with autologous IL2 and CD40 ligand-expressing tumor cells + lenalidomide
- Developing novel therapeutics for endocrine cancers
- Using zebrafish to identify modifiers of chronic disease
- Novel ligands for nuclear receptors CAR and LRH-1
Neilson, Joel R. - Post-transcriptional gene regulation in mammalian development and disease by microRNAs and RNA-binding proteins
- Small molecule inhibitors of a brain-specific membrane transporter
Nuchtern, Jed - Target discovery for chemotherapy-resistant pediatric cancer
- Development of small molecule inhibitors for a novel class of proteins: the nuclear receptor coactivators
- Inhibitors of AP1 which contribute to endocrine therapy resistance in breast cancer models
- Development of small molecule inhibitors of antibiotic resistance enzymes
Pan, Jenny Szu-Chin - Kidney Protection by Mitochondrial Sensors, AMPK and Sirtuin 3
- Small molecular inhibitors of primary peritoneal and ovarian cancers
- Small molecular inhibitors of separase
- Screens for small molecule regulators of circadian rhythms, and for antioxidants against ROS
Peters, Christopher - In vitro small molecule screening for the identification of autophagy modulators
- Redesigning potassium channels for improved drug discovery
Phillips, Kevin - Small molecule modulation of the mammalian deiodinases
- Investigation of Akt isoform-specific inhibitors
Pollet, Jeroen - Screening protein-excipient interactions to optimize the stability of recombinant vaccine candidates against neglected tropical diseases
- Small molecule antivirals for gastroenteric viral pathogens
Members R-Z
- Novel Stat3 inhibitors for improving outcomes in acute myeloid leukemia; Novel histone methyltransferase inhibitors for improving outcomes in MLL-rearranged acute leukemias
- Small molecules that regulate nuclear receptors in ovarian follicle development and epithelial ovarian cancer
- HTS assays to identify small molecules that target EMT/TIC pathways in chemoresistant cancers
Savidge, Tor - Small molecule targeting of the Clostridium difficile toxins
- Inhibitors of AP1 which contribute to endocrine therapy resistance in breast cancer models
Sheikh-Hamad, David - Small molecule manipulation of mitochondrial pathways for kidney protection
- Small drug-mediated interrogation of mammalian proteostasis networks
- Selective Inhibitors of corepressors for the nuclear receptor superfamily
- Rational design and development of novel small molecule inhibitors of biologically important proteins targeting cancer and infectious diseases
St-Pierre, François - High-throughput screening of genetically encoded sensors of cellular activity
- Pharmacological inhibitors of NEDD4 ubiquitin ligase as anticancer therapeutics
- Ghrelin receptor antagonists in brown fat thermogenesis, adiposity and insulin resistance; Ghrelin and des-acyl ghrelin in muscle atrophy
- Exploiting protein structure and function to develop new anti-cancer drugs
- Screening of small molecular compounds for inhibition of COUP-TFII activity
- Synaptotagmin 2 is a novel target for the treatment of mucus hypersecretion in the airway
- Virtual ligand screening, high throughput fluorescent microscopy screening, and SAR-assisted medicinal chemistry to target STAT proteins
Venken, Koen - Multicolor poly-luciferase assays for quick affordable multiplex analysis of cellular signaling pathways in health and disease
- Nanotechnology for drug, gene and RNAi delivery
- Lysosomal signaling molecules in regulation of lipid metabolism and longevity
- Drugs that modify ryanodine receptors for the treatment of heart disease
- Screens for small molecules that interrupt the interface between androgen receptor and p160 coactivators
- Novel therapeutics for retinal neurodegeneration and protein misfolding diseases
- Multidisciplinary program in genetics and drug discovery to exploit new breast cancer vulnerabilities
Xu, Jianming - Modulators of transcriptional coregulators for inhibition of cancer cell growth
- MAPK4 as a novel therapeutic target for human cancers
Yang, Jianchang - Role of Sall4 on leukemic hematopoietic and other cancer stem cell regulation
- Targeting oncogenic kinases in neuroblastoma
- HIV mucosal vaccine development; Pancreatic cancer pathogenesis and immunotherapy
- Developing riboswitch-based gene regulation systems that can be turned on or off by FDA-approved small molecules
Yi, Joanna - Identifying and translating novel, targeted small molecules to pediatric malignancies
- The role of TRAF4 in metastatic prostate cancer development
- Fragment-based drug discovery (FBDD) and macrocyclic scaffolds for drug discovery high-throughput screening (HTS)
Yu, Zhifeng - Small molecules for male contraception and ovarian cancer
- Discovery of small molecule modulators of orphan nuclear receptors
- Combating multidrug-resistant bacteria; gene therapy approaches for human diseases
- Small molecule modulation of cellular clearance as Alzheimer disease therapy
- Modulation of membrane transport proteins by small-molecule compounds
- Identification of protein-protein interactions and screening drug targets to understand sca1 pathogenesis and develop therapies
