²ÝÁñÉçÇøÈë¿Ú

Research

Metabolomics Core Publications

Master
Heading

Selected Publications Supported by the Metabolomics Core

Content

2024

  1. Meena JK, Wang JH, Neill NJ, Keough D, Putluri N, Katsonis P, Koire AM, Lee H, Bowling EA, Tyagi S, Orellana M, Dominguez-Vidaña R, Li H, Eagle K, Danan C, Chung HC, Yang AD, Wu W, Kurley SJ, Ho BM, Zoeller JR, Olson CM, Meerbrey KL, Lichtarge O, Sreekumar A, Dacso CC, Guddat LW, Rejman D, Hocková D, Janeba Z, Simon LM, Lin CY, Pillon MC, Westbrook TF. MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer. Cancer Discov. 2024 Sep 4;14(9):1699-1716. doi: 10.1158/2159-8290.CD-22-0649. PMID: 39193992; PMCID: PMC11372365.
  2. Kami Reddy KR, Piyarathna DWB, Park JH, Putluri V, Amara CS, Kamal AHM, Xu J, Kraushaar D, Huang S, Jung SY, Eberlin LS, Johnson JR, Kittles RA, Ballester LY, Parsawar K, Siddiqui MM, Gao J, Langer Gramer A, Bollag RJ, Terris MK, Lotan Y, Creighton CJ, Lerner SP, Sreekumar A, Kaipparettu BA, Putluri N. Mitochondrial reprogramming by activating OXPHOS via glutamine metabolism in African American patients with bladder cancer. JCI Insight. 2024 Sep 10;9(17):e172336. doi: 10.1172/jci.insight.172336. PMID: 39253977; PMCID: PMC11385078.  
  3. Amara CS, Kami Reddy KR, Yuntao Y, Chan YS, Piyarathna DWB, Dobrolecki LE, Shih DJH, Shi Z, Xu J, Huang S, Ellis MJ, Apolo AB, Ballester LY, Gao J, Hansel DE, Lotan Y, Hodges HC, Lerner SP, Creighton CJ, Sreekumar A, Zheng WJ, Msaouel P, Kavuri SM, Putluri N. The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer. Nat Commun. 2024 Feb 14;15(1):1373. doi: 10.1038/s41467-024-45132-2. PMID: 38355560; PMCID: PMC10867091.
  4. Ahn S, Park JH, Grimm SL, Piyarathna DWB, Samanta T, Putluri V, Mezquita D, Fuqua SAW, Putluri N, Coarfa C, Kaipparettu BA. Metabolomic Rewiring Promotes Endocrine Therapy Resistance in Breast Cancer. Cancer Res. 2024 Jan 16;84(2):291-304. doi: 10.1158/0008-5472.CAN-23-0184. PMID: 37906431; PMCID: PMC10842725.
  5. Talwar C, Davuluri GVN, Kamal AHM, Coarfa C, Han SJ, Veeraragavan S, Parsawar K, Putluri N, Hoffman K, Jimenez P, Biest S, Kommagani R. Identification of distinct stool metabolites in women with endometriosis for non-invasive diagnosis and potential for microbiota-based therapies. Med. 2025 Feb 14;6(2):100517. doi: 10.1016/j.medj.2024.09.006. Epub 2024 Oct 11. PMID: 39395412; PMCID: PMC11830556.
  6. Sharma P, Jain T, Sorgen A, Iyer S, Tarique M, Roy P, Kurtom S, Sethi V, Bava EP, Gutierrez-Garcia AK, Vaish U, Suresh DS, Sahay P, Edwards D, Afghani J, Putluri S, Reddy KRK, Amara CS, Kamal AHM, Fodor A, Dudeja V. Smoking-induced gut microbial dysbiosis mediates cancer progression through modulation of anti-tumor immune response. iScience. 2025 Feb 11;28(3):112002. doi: 10.1016/j.isci.2025.112002. PMID: 40104059; PMCID: PMC11914281.
  7. Hudobenko J, Di Gesù CM, Mooz PR, Petrosino J, Putluri N, Ganesh BP, Rebeles K, Blixt FW, Venna VR, McCullough LD. Maternal dysbiosis produces long-lasting behavioral changes in offspring. Mol Psychiatry. 2024 Oct 23. doi: 10.1038/s41380-024-02794-0. Epub ahead of print. PMID: 39443733.
  8. Li Y, Yadollahi P, Essien F, Putluri V, Chandra S, Kami Reddy KR, Kamal A, Putluri N, Abdurrahman LM, Ruiz-Echartea E, Ernste K, Trivedi A, Vazquez-Perez J, Hudson WH, Decker W, Patel R, Osman AA, Kheradmand F, Lai SY, Myers JN, Skinner HD, Coarfa C, Lee K, Jain A, Malovannaya A, Frederick MJ, Sandulache VC. Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer. bioRxiv [Preprint]. 2024 Oct 21:2024.10.17.618907. doi:10.1101/2024.10.17.618907. PMID: 39484602; PMCID: PMC11526855.
  9. Yang S, Tang W, Azizian A, Gaedcke J, Ohara Y, Cawley H, Hanna N, Ghadimi M, Lal T, Sen S, Creighton CJ, Gao J, Putluri N, Ambs S, Hussain P. MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK-ERK and AP-1 pathways. Carcinogenesis. 2024 Aug 12;45(8):582-594. doi: 10.1093/carcin/bgae025. PMID: 38629149; PMCID: PMC11317528.
  10. Yazdani A, Samms-Vaughan M, Saroukhani S, Bressler J, Hessabi M, Tahanan A, Grove ML, Gangnus T, Putluri V, Kamal AHM, Putluri N, Loveland KA, Rahbar MH. Metabolomic Profiles in Jamaican Children With and Without Autism Spectrum Disorder. J Autism Dev Disord. 2024 Jul 20. doi: 10.1007/s10803-024-06485-1. Epub ahead of print. PMID: 39033254.
  11. Godfrey WH, Cho K, Deng X, Ambati CSR, Putluri V, Mostafa Kamal AH, Putluri N, Kornberg MD. Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism. bioRxiv [Preprint]. 2024 Jun 28:2024.06.23.600101. doi: 10.1101/2024.06.23.600101. PMID: 38979375; PMCID: PMC11230282.
  12. Elbialy A, Kappala D, Desai D, Wang P, Fadiel A, Wang SJ, Makary MS, Lenobel S, Sood A, Gong M, Dason S, Shabsigh A, Clinton S, Parwani AV, Putluri N, Shvets G, Li J, Liu X. Patient-Derived Conditionally Reprogrammed Cells in Prostate Cancer Research. Cells. 2024 Jun 8;13(12):1005. doi: 10.3390/cells13121005. PMID: 38920635; PMCID: PMC11201841.
  13. Rasouli S, Dakic A, Wang QE, Mitchell D, Blakaj DM, Putluri N, Li J, Liu X. Noncanonical functions of telomerase and telomeres in viruses-associated cancer. J Med Virol. 2024 May;96(5):e29665. doi: 10.1002/jmv.29665. PMID: 38738582.
  14. Czerniak B, Lee S, Jung SY, Kus P, Bondaruk J, Lee J, Jaksik R, Putluri N, Dinh K, Cogdell D, Chen H, Wang Y, Chen J, Nevai N, Dinney C, Mendelsohn C, McConkey D, Behringer R, Guo C, Wei P, Kimmel M. Inferring Bladder Cancer Evolution from Mucosal field Effects by Whole-Organ Spatial Mutational, Proteomic, and Metabolomic Mapping. Res Sq [Preprint]. 2024 Apr 10:rs.3.rs-3994376. doi: 10.21203/rs.3.rs-3994376/v1. PMID: 38659962; PMCID: PMC11042420.
  15. Murthy D, Dutta D, Attri KS, Samanta T, Yang S, Jung KH, Latario SG, Putluri V, Huang S, Putluri N, Park JH, Kaipparettu BA. CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer. Cancer Lett. 2024 Apr 10;587:216724. doi: 10.1016/j.canlet.2024.216724. Epub 2024 Feb 17. PMID: 38373689; PMCID: PMC11068061.
  16. Wang DH, Fujita Y, Dono A, Rodriguez Armendariz AG, Shah M, Putluri N, Pichardo-Rojas PS, Patel CB, Zhu JJ, Huse JT, Parker Kerrigan BC, Lang FF, Esquenazi Y, Ballester LY. The genomic alterations in glioblastoma influence the levels of CSF metabolites. Acta Neuropathol Commun. 2024 Jan 19;12(1):13. doi: 10.1186/s40478-024-01722-1. PMID: 38243318; PMCID: PMC10799404. 

2023

  1. Charles C, Lloyd SM, Piyarathna DWB, Gohlke J, Rasaily U, Putluri V, Simons BW, Zaslavsky A, Nallandhighal S, Michailidis G, Palanisamy N, Navone N, Jones JA, Ittmann MM, Putluri N, Rowley DR, Salami SS, Palapattu GS, Sreekumar A. Role of adenosine deaminase in prostate cancer progression. Am J Clin Exp Urol. 2023 Dec 15;11(6):594-612. PMID: 38148936; PMCID: PMC10749386.
  2. Ahn S, Park JH, Grimm SL, Piyarathna DWB, Samanta T, Putluri V, Mezquita D, Fuqua SAW, Putluri N, Coarfa C, Kaipparettu BA. Metabolomic rewiring promotes endocrine therapy resistance in breast cancer. Cancer Res. 2023 Oct 31. doi: 10.1158/0008-5472.CAN-23-0184. Epub ahead of print. PMID: 37906431.
  3. Purushothaman A, Oliva-Ramírez J, Treekitkarnmongkol W, Sankaran D, Hurd MW, Putluri N, Maitra A, Haymaker C, Sen S. Differential Effects of Pancreatic Cancer-Derived Extracellular Vesicles Driving a Suppressive Environment. Int J Mol Sci. 2023 Sep 27;24(19):14652. doi: 10.3390/ijms241914652. PMID: 37834100; PMCID: PMC10572854.
  4. Arunachalam AR, Samuel SS, Mani A, Maynard JP, Stayer KM, Dybbro E, Narayanan S, Biswas A, Pathan S, Soni K, Kamal AHM, Ambati CSR, Putluri N, Desai MS, Thevananther S. P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality. Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1;325(5):G471-G491. doi: 10.1152/ajpgi.00090.2023. Epub 2023 Sep 12. PMID: 37697947.
  5. Zachariah JP, Pena S, Lupo PJ, Putluri N, Penny DJ, Richard MA. Effect of exogenous l-carnitine on aortic stiffness in dyslipidemic adolescents: Design of a quadruple-blind, randomized, controlled interventional trial. Contemp Clin Trials Commun. 2023 Jun 30;34:101174. doi: 10.1016/j.conctc.2023.101174. PMID: 37448910; PMCID: PMC10338141.
  6. Masschelin PM, Saha P, Ochsner SA, Cox AR, Kim KH, Felix JB, Sharp R, Li X, Tan L, Park JH, Wang L, Putluri V, Lorenzi PL, Nuotio-Antar AM, Sun Z, Kaipparettu BA, Putluri N, Moore DD, Summers SA, McKenna NJ, Hartig SM. Vitamin B2 enables regulation of fasting glucose availability. Elife. 2023 Jul 7;12:e84077. doi: 10.7554/eLife.84077. PMID: 37417957; PMCID: PMC10328530.
  7. Nguyen T, Sridaran D, Chouhan S, Weimholt C, Wilson A, Luo J, Li T, Koomen J, Fang B, Putluri N, Sreekumar A, Feng FY, Mahajan K, Mahajan NP. Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer. Nat Commun. 2023 Jun 9;14(1):3357. doi: 10.1038/s41467-023-38887-7. Erratum in: Nat Commun. 2023 Sep 27;14(1):6022. PMID: 37296155; PMCID: PMC10256812.
  8. Chakraborty S, Lulla A, Cheng X, Yeo JY, Mandal J, Yang T, Mei X, Saha P, Golonka RM, Yeoh BS, Mell B, Jia W, Putluri V, Piyarathna DWB, Putluri N, Sreekumar A, Meyer K, Vijay-Kumar M, Joe B. Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites. J Hypertens. 2023 Jun 1;41(6):979-994. doi: 10.1097/HJH.0000000000003423. Epub 2023 Apr 5. PMID: 37071431; PMCID: PMC10158603.
  9. Yu W, Chen Y, Putluri N, Osman A, Coarfa C, Putluri V, Kamal AHM, Asmussen JK, Katsonis P, Myers JN, Lai SY, Lu W, Stephan CC, Powell RT, Johnson FM, Skinner HD, Kazi J, Ahmed KM, Hu L, Threet A, Meyer MD, Bankson JA, Wang T, Davis J, Parker KR, Harris MA, Baek ML, Echeverria GV, Qi X, Wang J, Frederick AI, Walsh AJ, Lichtarge O, Frederick MJ, Sandulache VC. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer. 2023 Jun;128(11):2013-2024. doi: 10.1038/s41416-023-02253-7. Epub 2023 Apr 3. PMID: 37012319; PMCID: PMC10205814.
  10. Alghetaa H, Mohammed A, Singh N, Wilson K, Cai G, Putluri N, Nagarkatti M, Nagarkatti P. Resveratrol attenuates staphylococcal enterotoxin B-activated immune cell metabolism via upregulation of miR-100 and suppression of mTOR signaling pathway. Front Pharmacol. 2023 Feb 24;14:1106733. doi: 10.3389/fphar.2023.1106733. PMID: 36909201; PMCID: PMC9999031.
  11. Chadchan SB, Naik SK, Popli P, Talwar C, Putluri S, Ambati CR, Lint MA, Kau AL, Stallings CL, Kommagani R. Gut microbiota and microbiota-derived metabolites promotes endometriosis. Cell Death Discov. 2023 Jan 25;9(1):28. doi: 10.1038/s41420-023-01309-0. PMID: 36693853; PMCID: PMC9873805.
  12. Thaiparambil J, Amara CS, Sen S, Putluri N, El-Zein R. Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells. Cancer Med. 2023 Apr;12(7):8499-8509. doi: 10.1002/cam4.5599. Epub 2023 Jan 9. PMID: 36621828; PMCID: PMC10134322.
  13. Hahn AW, Menk AV, Rivadeneira DB, Augustin RC, Xu M, Li J, Wu X, Mishra AK, Gide TN, Quek C, Zang Y, Spencer CN, Menzies AM, Daniel CR, Hudgens CW, Nowicki T, Haydu LE, Khan MAW, Gopalakrishnan V, Burton EM, Malke J, Simon JM, Bernatchez C, Putluri N, Woodman SE, Vashisht Gopal YN, Guerrieri R, Fischer GM, Wang J, Wani KM, Thompson JF, Lee JE, Hwu P, Ajami N, Gershenwald JE, Long GV, Scolyer RA, Tetzlaff MT, Lazar AJ, Schadendorf D, Wargo JA, Kirkwood JM, DeBerardinis RJ, Liang H, Futreal A, Zhang J, Wilmott JS, Peng W, Davies MA, Delgoffe GM, Najjar YG, McQuade JL. Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma. Clin Cancer Res. 2023 Jan 4;29(1):154-164. doi: 10.1158/1078-0432.CCR-22-2661. PMID: 36166093; PMCID: PMC10311539.
  14. Thaiparambil J, Dong J, Grimm SL, Perera D, Ambati CSR, Putluri V, Robertson MJ, Patel TD, Mistretta B, Gunaratne PH, Kim MP, Yustein JT, Putluri N, Coarfa C, El-Zein R. Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer. Cancer Med. 2023 Jan;12(1):584-596. doi: 10.1002/cam4.4933. Epub 2022 Jun 8. PMID: 35676822; PMCID: PMC9844651.

2022

  1. Tao L, Mohammad MA, Milazzo G, Moreno-Smith M, Patel TD, Zorman B, Badachhape A, Hernandez BE, Wolf AB, Zeng Z, Foster JH, Aloisi S, Sumazin P, Zu Y, Hicks J, Ghaghada KB, Putluri N, Perini G, Coarfa C, Barbieri E. MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma. Nat Commun. 2022 Jun 28;13(1):3728. doi: 10.1038/s41467-022-31331-2. PMID: 35764645; PMCID: PMC9240069.Stork BA, Dean A, Ortiz AR, Saha P, Putluri N, Planas-Silva MD, Mahmud I, Rajapakshe K, Coarfa C, Knapp S, Lorenzi PL, Kemp BE, Turk BE, Scott JW, Means AR, York B. Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism. Mol Metab. 2022 Aug;62:101513. doi: 10.1016/j.molmet.2022.101513. Epub 2022 May 11. PMID: 35562082; PMCID: PMC9157561.
  2. Fujita Y, Nunez-Rubiano L, Dono A, Bellman A, Shah M, Rodriguez JC, Putluri V, Kamal AHM, Putluri N, Riascos RF, Zhu JJ, Esquenazi Y, Ballester LY. IDH1 p.R132H ctDNA and D-2-hydroxyglutarate as CSF biomarkers in patients with IDH-mutant gliomas. J Neurooncol. 2022 Jul 11. doi: 10.1007/s11060-022-04060-1. Epub ahead of print. PMID: 35816267.
  3. Kami Reddy KR, Piyarathna DWB, Kamal AHM, Putluri V, Ravi SS, Bollag RJ, Terris MK, Lotan Y, Putluri N. Lipidomic Profiling Identifies a Novel Lipid Signature Associated with Ethnicity-Specific Disparity of Bladder Cancer. Metabolites. 2022 Jun 14;12(6):544. doi: 10.3390/metabo12060544. PMID: 35736477; PMCID: PMC9230655.
  4. El Saie A, Fu C, Grimm SL, Robertson MJ, Hoffman K, Putluri V, Ambati CSR, Putluri N, Shivanna B, Coarfa C, Pammi M. Metabolome and microbiome multi-omics integration from a murine lung inflammation model of bronchopulmonary dysplasia. Pediatr Res. 2022 Mar 25. doi: 10.1038/s41390-022-02002-1. Epub ahead of print. PMID: 35338351.
  5. Odunsi K, Qian F, Lugade AA, Yu H, Geller MA, Fling SP, Kaiser JC, Lacroix AM, D'Amico L, Ramchurren N, Morishima C, Disis ML, Dennis L, Danaher P, Warren S, Nguyen VA, Ravi S, Tsuji T, Rosario S, Zha W, Hutson A, Liu S, Lele S, Zsiros E, McGray AJR, Chiello J, Koya R, Chodon T, Morrison CD, Putluri V, Putluri N, Mager DE, Gunawan R, Cheever MA, Battaglia S, Matsuzaki J. Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses. Sci Transl Med. 2022 Mar 16;14(636):eabg8402. doi: 10.1126/scitranslmed.abg8402. Epub 2022 Mar 16. PMID: 35294258.
  6. Meng H, Gonzales NM, Jung SY, Lu Y, Putluri N, Zhu B, Dacso CC, Lonard DM, O'Malley BW. Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism. Cell Rep. 2022 Mar 8;38(10):110491. doi: 10.1016/j.celrep.2022.110491. PMID: 35263593; PMCID: PMC8958721.
  7. Jaggupilli A, Ly S, Nguyen K, Anand V, Yuan B, El-Dana F, Yan Y, Arvanitis Z, Piyarathna DWB, Putluri N, Piwnica-Worms H, Manning HC, Andreeff M, Battula VL. Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer. Br J Cancer. 2022 Mar;126(4):615-627. doi: 10.1038/s41416-021-01636-y. Epub 2021 Nov 22. PMID: 34811508; PMCID: PMC8854435.
  8. Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q, Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J, Zhang L, Sun Z. Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox. Circulation. 2022 Feb 8;145(6):448-464. doi: 10.1161/CIRCULATIONAHA.121.056076. Epub 2022 Jan 17. PMID: 35034472; PMCID: PMC8812427.

2021

  1. Ravindran A, Piyarathna DWB, Gohlke J, Putluri V, Soni T, Lloyd S, Castro P, Pennathur S, Jones JA, Ittmann M, Putluri N, Michailidis G, Rajendiran TM, Sreekumar A. Lipid Alterations in African American Men with Prostate Cancer. Metabolites. 2021 Dec 22;12(1):8. doi: 10.3390/metabo12010008. PMID: 35050130; PMCID: PMC8779756.
  2. Chadchan SB, Popli P, Ambati CR, Tycksen E, Han SJ, Bulun SE, Putluri N, Biest SW, Kommagani R. Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis. Life Sci Alliance. 2021 Sep 30;4(12):e202101224. doi: 10.26508/lsa.202101224. PMID: 34593556; PMCID: PMC8500332.
  3. Burke R, Chu C, Zhou GD, Putluri V, Putluri N, Stading RE, Couroucli X, Lingappan K, Moorthy B. Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative DNA Damage in Human Pulmonary Cells. Oxid Med Cell Longev. 2021 Oct 15;2021:5544600. doi: 10.1155/2021/5544600. PMID: 34691356; PMCID: PMC8536466.
  4. Tao L, Moreno-Smith M, Ibarra-García-Padilla R, Milazzo G, Drolet NA, Hernandez BE, Oh YS, Patel I, Kim JJ, Zorman B, Patel T, Kamal AHM, Zhao Y, Hicks J, Vasudevan SA, Putluri N, Coarfa C, Sumazin P, Perini G, Parchem RJ, Uribe RA, Barbieri E. CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming. Adv Sci (Weinh). 2021 Oct;8(19):e2005047. doi: 10.1002/advs.202005047. Epub 2021 Aug 8. PMID: 34365742; PMCID: PMC8498874.
  5. Yang D, Patel S, Szlachcic WJ, Chmielowiec J, Scaduto D, Putluri N, Sreekumar A, Suliburk J, Metzker M, Balasubramanyam A, Borowiak M. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes. Diabetes. 2021 Oct;70(10):2419-2429. doi: 10.2337/db20-1293. Epub 2021 Aug 3. PMID: 34344789; PMCID: PMC8576504.
  6. Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C, Liao L, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD, Putluri N, Coarfa C, Hawke DH, Gunaratne PH, Tsai KL, Han L, Hung MC, Calin GA, Namour F, Guéant JL, Muntau AC, Blau N, Sutton VR, Schiff M, Feillet F, Zhang S, Lin C, Yang L. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science. 2021 Aug 6;373(6555):662-673. doi: 10.1126/science.aba4991. PMID: 34353949.
  7. Moreno-Smith M, Milazzo G, Tao L, Fekry B, Zhu B, Mohammad MA, Di Giacomo S, Borkar R, Reddy KRK, Capasso M, Vasudevan SA, Sumazin P, Hicks J, Putluri N, Perini G, Eckel-Mahan K, Burris TP, Barbieri E. Restoration of the molecular clock is tumor suppressive in neuroblastoma. Nat Commun. 2021 Jun 28;12(1):4006. doi: 10.1038/s41467-021-24196-4. PMID: 34183658; PMCID: PMC8238982.
  8. Chen Y, Maniakas A, Tan L, Cui M, Le X, Niedzielski JS, Michel KA, Harlan CJ, Lu W, Henderson YC, Mohamed ASR, Lorenzi PL, Putluri N, Bankson JA, Sandulache VC, Lai SY. Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer. Br J Cancer. 2021 May;124(10):1670-1679. doi: 10.1038/s41416-021-01297-x. Epub 2021 Mar 19. PMID: 33742144; PMCID: PMC8110762.
  9. Shi H, Zhang B, Abo-Hamzy T, Nelson JW, Ambati CSR, Petrosino JF, Bryan RM Jr, Durgan DJ. Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure. Circ Res. 2021 Apr 30;128(9):1240-1254. doi: 10.1161/CIRCRESAHA.120.318155. Epub 2021 Feb 18. Erratum in: Circ Res. 2022 Mar 4;130(5):e18. PMID: 33596669; PMCID: PMC8085162.
    Cermakova K, Smith EA, Chan YS, Cabrera ML, Chambers C, Jarvis MI, Simon LM, Xu Y, Jain A, Putluri N, Chen R, Ripley RT, Veiseh O, Hodges HC. SMARCA4 regulates spatially restricted metabolic plasticity in 3D multicellular tissue. bioRxiv. 2021:2021.03.21.436346. doi: 10.1101/2021.03.21.436346. 

2020

  1. Alam H, Tang M, Maitituoheti M, Dhar SS, Kumar M, Han CY, Ambati CR, Amin SB, Gu B, Chen T-Y, Lin Y-H, Chen J, Muller FL, Putluri N, Flores ER, DeMayo FJ, Baseler L, Rai K, Lee MG. KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in  Lung Cancer. Cancer Cell. 2020 Apr;37(4):599-617.e7. PMID: 32243837
  2. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH-F, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast  cancer progression. Oncogene. 2020 Apr;39(15):3089–3101. PMID: 31308490
  3. Choi S, Dong B, Lin C-CJ, Heo MJ, Kim KH, Sun Z, Wagner M, Putluri N, Suh JM, Wang MC, Moore DD. Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial  Function in Mouse Hepatocytes. Hepatology. 2020 Mar;71(3):1055–1069. PMID: 31355949
  4. Cox AR, Chernis N, Bader DA, Saha PK, Masschelin PM, Felix JB, Sharp R, Lian Z, Putluri V, Rajapakshe K, Kim KH, Villareal DT, Armamento-Villareal R, Wu H, Coarfa C, Putluri N, Hartig SM. STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity. Diabetes. United States; 2020 Sep; PMID: 32994273
  5. Dey P, Li J, Zhang J, Chaurasiya S, Strom A, Wang H, Liao W-T, Cavallaro F, Denz P, Bernard V, Yen E-Y, Genovese G, Gulhati P, Liu J, Chakravarti D, Deng P, Zhang T, Carbone F, Chang Q, Ying H, Shang X, Spring DJ, Ghosh B, Putluri N, Maitra A, Wang YA, DePinho RA. Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes  Cytokines from the Tumor Microenvironment. Cancer Discov. 2020 Apr;10(4):608–625. PMID: 32046984
  6. Dono A, Patrizz A, McCormack RM, Putluri N, Ganesh BP, Kaur B, McCullough LD, Ballester LY, Esquenazi Y. Glioma induced alterations in fecal short-chain fatty acids and neurotransmitters. CNS Oncol. 2020 Jun;9(2):CNS57. PMID: 32602743
  7. Gastelum G, Jiang W, Wang L, Zhou G, Borkar R, Putluri N, Moorthy B. Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450  (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2. Toxicol Sci. United States; 2020 Oct;177(2):347–361. PMID: 32726451
    Honarpisheh P, Reynolds CR, Blasco Conesa MP, Moruno Manchon JF, Putluri N, Bhattacharjee MB, Urayama A, McCullough LD, Ganesh BP. Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain  Amyloid-β in Tg2576 Mice. Int J Mol Sci. 2020 Mar;21(5). PMID: 32138161
  8. Lee J, d’Aigle J, Atadja L, Quaicoe V, Honarpisheh P, Ganesh BP, Hassan A, Graf J, Petrosino J, Putluri N, Zhu L, Durgan DJ, Bryan RMJ, McCullough LD, Venna VR. Gut Microbiota-Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice. Circ Res. 2020 Jul;127(4):453–465. PMID: 32354259
  9. Lee J, Venna VR, Durgan DJ, Shi H, Hudobenko J, Putluri N, Petrosino J, McCullough LD, Bryan RM. Young versus aged microbiota transplants to germ-free mice: increased short-chain  fatty acids and improved cognitive performance. Gut Microbes. United States; 2020 Sep;1–14. PMID: 32897773
  10. Lovisa S, Fletcher-Sananikone E, Sugimoto H, Hensel J, Lahiri S, Hertig A, Taduri G, Lawson E, Dewar R, Revuelta I, Kato N, Wu C-J, Bassett RLJ, Putluri N, Zeisberg M, Zeisberg EM, LeBleu VS, Kalluri R. Endothelial-to-mesenchymal transition compromises vascular integrity to induce  Myc-mediated metabolic reprogramming in kidney fibrosis. Sci Signal. United States; 2020 Jun;13(635). PMID: 32518142
  11. Meng H, Gonzales NM, Lonard DM, Putluri N, Zhu B, Dacso CC, York B, O’Malley BW. XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid  homeostasis. Nat Commun. 2020 Dec;11(1):6215. PMID: 33277471
  12. Mohammed A, F K Alghetaa H, Miranda K, Wilson K, P Singh N, Cai G, Putluri N, Nagarkatti P, Nagarkatti M. Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome  through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression. Int J Mol Sci. 2020 Aug;21(17). PMID: 32872332
  13. Nagandla H, Robertson MJ, Putluri V, Putluri N, Coarfa C, Weigel NL. Isoform specific activities of androgen receptor and its splice variants in prostate  cancer cells. Endocrinology. United States; 2020 Dec; PMID: 33300995
  14. Sawant Dessai A, Palestino Dominguez M, Chen U-I, Hasper J, Prechtl C, Yu C, Katsuta E, Dai T, Zhu B, Jung SY, Putluri N, Takabe K, Zhang XH-F, O’Malley BW, Dasgupta S. Transcriptional repression of SIRT3 potentiates mitochondrial aconitase activation  to drive aggressive prostate cancer to the bone. Cancer Res. United States; 2020 Oct; PMID: 33115805
  15. Takayasu T, Shah M, Dono A, Yan Y, Borkar R, Putluri N, Zhu J-J, Hama S, Yamasaki F, Tahara H, Sugiyama K, Kurisu K, Esquenazi Y, Ballester LY. Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the  evaluation of CNS germ cell tumors. Sci Rep. 2020 Aug;10(1):14326. PMID: 32868820
    Treviño LS, Dong J, Kaushal A, Katz TA, Jangid RK, Robertson MJ, Grimm SL, Ambati CSR, Putluri V, Cox AR, Kim KH, May TD, Gallo MR, Moore DD, Hartig SM, Foulds CE, Putluri N, Coarfa C, Walker CL. Epigenome environment interactions accelerate epigenomic aging and unlock  metabolically restricted epigenetic reprogramming in adulthood. Nat Commun. 2020 May;11(1):2316. PMID: 32385268
  16. Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Atp7b (-/-) Wilson’s disease mouse model. Proc Natl Acad Sci U S A. 2020 Jan;117(4):2076–2083. PMID: 31924743
  17. Xue L, Chen F, Yue F, Camacho L, Kothapalli S, Wei G, Huang S, Mo Q, Ma F, Li Y, Jiralerspong S. Metformin and an insulin/IGF-1 receptor inhibitor are synergistic in blocking growth of triple-negative breast cancer. Breast Cancer Res Treat. 2020 Sep 17. PMID: 32940848.
  18. Yang T, Chakraborty S, Saha P, Mell B, Cheng X, Yeo J-Y, Mei X, Zhou G, Mandal J, Golonka R, Yeoh BS, Putluri V, Piyarathna DWB, Putluri N, McCarthy CG, Wenceslau CF, Sreekumar A, Gewirtz AT, Vijay-Kumar M, Joe B. Gnotobiotic Rats Reveal That Gut Microbiota Regulates Colonic mRNA of Ace2, the  Receptor for SARS-CoV-2 Infectivity. Hypertension (Dallas, Tex. : 1979). 2020. p. e1–e3. PMID: 32426999
  19. Yu W, Chen Y, Putluri N, Coarfa C, Robertson MJ, Putluri V, Stossi F, Dubrulle J, Mancini MA, Pang JC, Nguyen T, Baluya D, Myers JN, Lai SY, Sandulache VC. Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma  Metabolism toward Neutralization of Oxidative Stress. Cancers (Basel). 2020 Jun;12(6). PMID: 32599707
  20. Zhang X, Wang X, Wang XQD, Su J, Putluri N, Zhou T, Qu Y, Jeong M, Guzman A, Rosas C, Huang Y, Sreekumar A, Li W, Goodell MA. Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant  hematopoiesis. Blood. 2020 Mar;135(11):845–856. PMID: 31932841