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Email

yingbin.fu@bcm.edu

Positions

Professor - Sarah Campbell Blaffer Endowed Chair

Ophthalmology
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Houston, TX US

Addresses

Neurosensory Center (Office)

Room: NEUR-C 506
Houston, TX 77030
United States

Education

PhD from Michigan State University

05/1998 - Lansing, Michigan United States

Biochemistry

Postdoctoral Fellowship at Johns Hopkins University School of Medicine

05/2006 - Baltimore, Maryland United States

Visual Neurophysiology

BS from Peking University

05/1991 - Beijing, China

Biochemistry

Honors & Awards

Audacious Goals Challenge Prize

https://rebrand.ly/nih-award1

National Eye Institute (02/2013)

The Helen Juanita Reed Award for Macular Degeneration Research

BrightFocus Foundation (04/2018)

2021 NEI Audacious Goals Initiative Grant Award

https://www.nei.nih.gov/about/news-and-events/news/learning-how-transplanted-neurons-fit-0

National Eye Institute (09/2021 - 08/2026)

Professional Interests

• Angiogenesis, cholesterol metabolism, and inflammation
• Age-related macular degeneration, retinal degeneration
• Gene therapy

Professional Statement

The Fu lab is interested in using the visual system to study angiogenesis, cholesterol metabolism, inflammation, and the biological mechanisms underlying various types of neurodegeneration, and to develop innovative treatment strategies. The lab has made significant contributions toward the understanding of the role of a multifunctional serine protease HTRA1 in age-related macular degeneration (AMD), the pathogenesis of polypoidal choroidal vasculopathy (PCV, a variant of wet type AMD), and the role of cone opsins in cone photoreceptor degeneration. Our recent research includes the following projects: 1) the role of the apolipoprotein-A-I binding protein (AIBP) in AMD; 2) the mechanism and treatment strategies for anti-VEGF resistance in wet AMD; 3) lipid metabolism and AMD, and 4) generating novel models of photoreceptor degeneration for regenerative cell therapy (NIH U24 project). Our recent studies have identified a mechanism for anti-VEGF resistance in wet AMD and developed the first potential AIBP/apoa-I/anti-VEGF combination treatment to overcome anti-VEGF resistance (PCT/IB2021/055463 patent pending).The PI has won the National Institute of Health/National Eye Institute Audacious Goals Challenge Awards (https://rebrand.ly/nih-award1; https://rebrand.ly/nei-award1). We place emphasis in Translational Research-- discovering disease mechanisms and developing innovative treatment strategies. Due to the translational nature of our research, students and postdocs will have good employment opportunities in both academia and industry. With diverse research projects (from basic to translational), there is ample opportunity for incoming students. We welcome rotation students!
The Fu lab currently has one position open for a postdoc/research associate. Highly motivated candidates who are interested in addressing major health challenges facing our modern society are encouraged to apply at: https://jobs.bcm.edu/job/Houston-Postdoctoral-Associate-Texa/1004294800/.

Websites

Selected Publications

• Kumar S, Nakashizuka H, Jones A, Lambert A, Zhao X, Shen M, Parker M, Wang S, Berriochoa Z, Fnu A, VanBeuge S, Chévez-Barrios P, Tso M, Rainier J, Fu Y. "." Am J Pathol.. 2017 Dec 20;187(12):2841-2857. Pubmed PMID:
• Zhang T, Cao LH, Kumar S, Enemchukwu NO, Zhang N, Lambert A, Zhao X, Jones A, Wang S, Dennis EM, Fnu A, Ham S, Rainier J, Yau KW, Fu Y "." Proc Natl Acad Sci U S A.. 2016 Jul 26; Pubmed PMID:
• Zhang T, Enemchukwu NO, Jones A, Wang S, Dennis E, Watt CB, Pugh EN Jr, Fu Y. "." Hum Mol Genet.. 2015 Mar 15;24(6):1755-63. Pubmed PMID:
• Jones A, Kumar S, Zhang N, Tong Z, Yang JH, Watt C, Anderson J, Amrita, Fillerup H, McCloskey M, Luo L, Yang Z, Ambati B, Marc R, Oka C, Zhang K, Fu Y. "." Proc Natl Acad Sci U S A.. 2011 Aug 30;108(35):14578-83. Pubmed PMID:

Memberships

Association for Research in Vision and Ophthalmology