Positions
- Professor
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Breast Center; Department of Molecular & Cellular Biology; Department of Molecular Virology & Microbiology
草榴社区入口
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Houston, Texas United States
- Faculty Senator
-
草榴社区入口
Houston, Texas United States
- Member
-
Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Addresses
- BCM-Alkek Graduate School (Lab)
-
Mail Stop: BCM600
Houston, TX 77030
United States
Phone: (713) 798-3963
liyi@bcm.edu
- BCM-Alkek Graduate School (Office)
-
Mail Stop: BCM600
Houston, TX 77030
United States
Phone: (713) 798-3963
liyi@bcm.edu
Education
- BS from Jiangsu Agricultural College
- 07/1984 - Yangzhou, Jiangsu China, People's Rep
- MS from Jiangsu Agricultural College
- 07/1987 - Yangzhou, Jiangsu China, People's Rep
- PhD from Michigan State University
- 01/1996 - East Lansing, Michigan United States
- Postdoctoral Training at National Cancer Institute
- 01/2000 - Bethesda, Maryland United States
- Postdoctoral Training at Memorial Sloan Kettering Cancer Center
- 10/2002 - New York, New York United States
Professional Interests
- Mouse and rat models of breast cancer
- Immune cells and breast cancer metastasis and therapy
- JAK-STAT and Bcl-xL signaling breast cancer
Professional Statement
The Li lab has developed multiple novel mouse and rat models that closely mimic human breast cancer initiation and progression. Using these models and cell biological, biochemical, genetic, and omic approaches, they have gained insights into Wnt-EGFR signaling in cancer progression, and discovered a JAK2-STAT5-regulated anti-apoptosis mechanism in promoting breast cancer development. Furthermore, their preclinical work on intermittent anti-JAK treatment for preventing breast cancer has resulted in a multi-center window-of-opportunity clinical trial (TBCRC042). Their recent success in introducing oncogenic drivers directly into mammary cells in rats has led to first models that can fully mimic human ER+ breast cancer. They are now utilizing these models to study how ER+ breast tumors metastasize and develop resistance to cancer therapies.Websites
Selected Publications
- Du Z, Podsypanina K, Huang S, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck M, Allred DC, Lewis MT, Varmus HE, Li Y. "." Proc Natl Acad Sci USA.. 2006 Nov;103(46):17396-401. Pubmed PMID:
- 32) Reddy, J.P., Peddibhotla, S., Bu, W., Zhao, J., Haricharan, S., Du, Y.C., Podsypanina, K., Rosen, J.M., Donehower, L.A. and Li, Y "." PNAS. 2010;107(8):3728-33. Pubmed PMID:
- Jackson JG, Pant V, Li Q, Chang LL, Quint谩s-Cardama A, Garza D, Tavana O, Yang P, Manshouri T, Li Y, El-Naggar AK, Lozano G. "." Cancer Cell.. 2012 Jun;21:793-806. Pubmed PMID:
- Haricharan S, Hein SM, Dong J, Toneff MJ, Aina OH, Rao PH, Cardiff RD, Li Y. "." Oncogene.. 2013 Dec 9; Pubmed PMID:
- Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y. "." eLIFE. 2013 Dec 31;2:e00996.
- Hatcher RJ, Dong J, Liu S, Bian G, Contreras A, Wang T, Hilsenbeck SG, Li Y, Zhang P. "." Proc Natl Acad Sci USA.. 2014 Jan;111:1008-13. Pubmed PMID:
- Sinha, V.C., Qin, L. & Li, Y. "." Molecular cancer research. 2014;13:231-8. Pubmed PMID:
- Zheng, Z.-Y., Tian, L., Bu, W., Fan, C., Gao, X., Wang, H., Liao, Y.-H., Li, Y., Lewis, M.T., Edwards, D., Zwaka, T.P., Hilsenbeck, S.G., Medina, D., Perou, C.M., Creighton, C.J., Zhang, X.H-F., & Chang, E.C "." Cell Reports. 2015;12:511. Pubmed PMID:
- Choi, S., Chen, Z., Tang, L.H., Fang, Y., Shin, S.J., Panarelli, N.C., Chen, Y.T., Li, Y., Jiang, X. & Du, Y.C "." Nat Commun. 2016;7:10384. Pubmed PMID:
- Hein, S.M., Haricharan, S., Johnston, A.N., Toneff, M.J., Reddy, J.P., Dong, J., Bu, W. & Li, Y "." Oncogene. 2016;35:1461-7. Pubmed PMID:
- Dong, J., Zhao, W., Shi, A., Toneff, M., Lydon, J., & Li, Y. "." Oncogene. 2016;000. Pubmed PMID:
- Bu, W., Liu, Z., Jiang, W., Nagi, C., Huang, S., Edwards, D.P., Jo, E., Mo, Q., Creighton, C.J., Hilsenbeck, S.G., Leavitt, A.D., Lewis, M.T., Wong, S.T.C. & Li, Y "." Cancer Res. 2018 Oct 31; Pubmed PMID:
- Johnston, A.N., Bu, W., Hein, S., Garcia, S., Camacho, L., Xue, L., Qin, L., Nagi, C., Hilsenbeck, S.G., Kapali, J., Podsypanina, K., Nangia, J. and Li, Y. "." Breast Cancer Res. 2018 May 19;20:42. Pubmed PMID:
- Zhang, W., Bado, I.L., Hu, J., Wan, Y.W., Wu, L., Wang, H., Gao, Y., Jeong, H.H., Xu, Z., Hao, X., Lege, B.M., Al-Ouran, R., Li, L., Li, J., Yu, L., Singh, S., Lo, H.C., Niu, M., Liu, J., Jiang, W., Li, Y. "." Cell. 2021;184:2471-2486. Pubmed PMID:
- Yue F, Jiang W, Ku AT, Young AIJ, Zhang W, Souto EP, Gao Y, Yu Z, Wang Y, Creighton CJ, Nagi C, Wang T, Hilsenbeck SG, Feng XH, Huang S, Coarfa C, Zhang XH, Liu Q, Lin X, Li Y. "." Cancer Research. 2021;81:4441-4454.
- Young A, Bu W, Jiang W, Ku A, Kapali J, Dhamne S, Qin L, Hilsenbeck SG, Du YN, Li Y "." Cancer Prevention Res. 2022;15(3-10)
- Lin, M., Ku, A.T., Dong, J., Yue, F., Jiang, W., Ibrahim, A.A., Peng, F., Creighton, C.J., Nagi, C., Gutierrez, C., Rosen, J.M., Zhang, X.H., Hilsenbeck, S.G., Chen, X., Du, Y.N., Huang, S., Shi, A., Fan, Z. & Li, Y. "." Oncogene. 2022;41:5214-5222. Pubmed PMID:
- Ku, A.T., Young, A.I.J., Ibrahim, A.A., Bu, W., Jiang, W., Lin, M., Williams, L.C., McCue, B.L., Miles, G., Nagi, C., Behbod, F. & Li, Y "." Cancer Prevention Research. 2023;16:65-73. Pubmed PMID:
- Bu, W., Creighton, C.J., Heavener, K.S., Gutierrez, C., Dou, Y., Ku, A.T., Zhang, Y., Jiang, W., Urrutia, J., Jiang, W., Yue, F., Jia, L., Ibrahim, A., Zhang, B., Huang, S. & Li, Y "." Science Adv. 2023;9(19):eade0059. Pubmed PMID:
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