Positions
- Associate Professor
-
Medicine-Athero & Lipo
Cardiovascular Research Institute (CVRI)
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Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
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Houston, Texas United States
Addresses
- Cardiovascular Research Institute (CVRI) (Office)
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Room: BCMD-507D
Houston, TX 77030
United States
Education
- BS from Wuhan University
- 05/1996 - Wuhan, China
- Cell and Developmental Biology
- MS from Wuhan University
- 05/1999 - Wuhan, China
- Biochemistry and Biophysics
- PhD from University of Rochester
- 05/2004 - Rochester, New York United States
- Pharmacology
- Post-Doctoral Fellowship at University of North Carolina at Chapel Hill
- 05/2008 - Chapel Hill, North Carolina United States
- Cardiovascular Research
Professional Statement
Dr. Pi studies the molecular mechanisms underneath the regulation of endothelial cell functions during vascular development and a variety of pathological conditions such as inflammation, atherosclerosis, peripheral vascular disease, cancer, diabetes and obesity. Her particular focus is to understand the signaling pathways associated with endothelial function that are critical in order to develop treatments for these vascular-associated conditions. Particular attentions are directed toward LRP1 (low density lipoprotein receptor-related protein 1) – and Bmper (Bmp-binding endothelial cell precursor-derived regulator)-dependent signaling pathways. Her work focuses on understanding how endothelial cells respond to ligand, initiate signaling cascades and cellular events such as proliferation, migration, differentiation, angiogenesis, inflammation and atherosclerosis, and change the metabolism to satisfy their needs at different active status.Websites
Publications listed in PubMed
Selected Publications
- Mao H, Angelini A, Li S, Wang G, Li L, Patterson C, Pi X, Xie L. "." Nat. Metab.. 2023;5(8):1382-1394. Pubmed PMID:
- Angelini A, Pi X, Xie L. "." STAR Protoc.. 2022;3(2):101392. Pubmed PMID:
- Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne CM, Hartig SM, Xie L, Pi X. "." Nature Communications. 2021;12(1):1927. Pubmed PMID:
- Angelini A, Saha PK, Jain A, Jung SY, Mynatt RL, Pi X, Xie L. "." Cell Reports. 2021;37(1):109767. Pubmed PMID:
- Mao H, Li L, Fan Q, Angelini A, Saha PK, Coarfa C, Rajapakshe K, Perera D, Cheng J, Wu H, Ballantyne CM, Sun Z, Xie L, Pi X. "." Nat Commun.. 2021;12(1):5296. Pubmed PMID:
- Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L "." Circulation.. 2019;140(5):440-442. Pubmed PMID:
- Pi X, Xie L, Patterson C. "." Circ Res. 2018;123(4):477-494. Pubmed PMID:
- Fan Q, Mao H, Xie L, Pi X "." Am J Pathol. 2018;89(1):200-213. Pubmed PMID:
- Mao H, Lockyer P, Li L, Ballantyne CM, Patterson C, Xie L, Pi X. "." Nature Communications. 2017;8:14960. Pubmed PMID:
- Mao H, Xie L, Pi X. "LDL receptor related protein-1 signaling in angiogenesis.." Front Cardiovasc Med. 2017;4:34.
- 8) Lockyer P, Mao H, Fan Q, Li L, LYu-Lee L, Eissa NT, Patterson C, Xie L, Pi X. "." Arterioscler Thromb Vasc Biol. 2017;37(8):1524-1535. Pubmed PMID:
- Mao H, Lockyer P, Townley-Tilson WH, Xie L, Pi X. "." Arterioscler Thromb Vasc Biol. 2016;36(2):350-60. Pubmed PMID:
- Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C. "PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.." J Clin Invest. 2015;125(7):2759-71.
- Xie L, Pi X, Wang Z, Willis MS, Patterson C. "Depletion of PHD3 protects hearts from injury induced by ischemia/reperfusion and inhibits cardiomyocyte apoptosis induced by oxidative stress.." J Mol Cell Cardiol. 2015;156-165.
- Townley-Tilson WHD, Pi X, Xie L. "The role of oxygen sensors, hydroxylases, and HIF in cardiac function and disease.." Oxid Med Cell Longev. 2015;676893.
- Dyer L, Lockyer P, Wu Y, Saha A, Cyr C, Moser M, Pi X, Patterson C. "BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions.." PLoS One. 2015;10(9):e0139209.
- Cai Y, Nagel DJ, Zhou Q, Li F, Pi X, Knight PA, Yan C. "Role of cAMP-Phosphodiesterase 1C Signaling in Regulating Growth Factor Receptor Stability, Vascular Smooth Muscle Cell Growth, Migration, and Neointimal Hyperplasia.." Circ Res. 2015;114:304408.
- Gomes AV, Rajasekaran NS, Pi X. "Redox Signaling and the Cardiovascular and Skeletal Muscle System.." Oxid Med Cell Longev. 2015;849095.
- Dyer La, Pi X, Patterson C. "." Trends Endocrinol Metab. 2014 Sep;25(9):472-480. Pubmed PMID:
- Dyer La, Pi X, Patterson C. "." Developmental Biology. 2014 Nov;395(1):111-119. Pubmed PMID:
- Pi X, Xie L, Portbury Al,Kumar S, Lockyer P, Li X, Patterson C "." Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2023-2032. Pubmed PMID:
- Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ 3rd, Jin SW, Patterson C. "An LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.." Circ Res. 2012;111(5):564-74.
- Pi X, Lockyer P, Dyer L, Schisler J, Carey S, Sweet D, Chen Z, Tzima E, Willis M, Homeister J, Moser M, Patterson C "Bmper inhibits endothelial inflammation and protects against atherosclerosis.." Arterioscler Thromb Vasc Biol. 2012;32(9):2214-22.
- Xie L1, Pi X, Mishra A, Fong G, Peng J, Patterson C. "." J Clin Invest. 2012 Aug;122(8):2827-2836. Pubmed PMID:
- Pi X, Wu Y, Ferguson JE 3rd, Portbury AL, Patterson C. "SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration.." Proc Natl Acad Sci USA. 2009;106(14):5675-80.
- Pi X, Ren R, Kelley R, Zhang C, Moser M, Bohil A, DiVito M, Cheney RE, Patterson C. "Sequential roles for Myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors.." J Cell Biol. 2007;179(7):1569-82.
- Pi X, Garin G, Xie L, Zheng Q, Wei H, Abe J, Yan C, Berk BC. "BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha.." Circ Res. 2005;96(11):1145-51.
- Pi X, Yan C, Berk BC. "Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis.." Circ Res. 2004;94(3):362-369.
Memberships
- American Heart Association
- Member (01/2001)
- North American Vascular Biology Organization
- Member (01/2001)
- American Diabetes Association
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