XIN LI, PhD
Picture
XIN LI, PhD
Instructor
Positions
- Instructor
-
Pharmacology & Chemical Biology
草榴社区入口
Houston, Texas United States
- Associate member
-
草榴社区入口
Dan L Duncan Comprehensive Cancer Center
Houston, Texas United States
Addresses
- 草榴社区入口 (Office)
-
1 Baylor Plaza
Alkek building, N510
Houston, TX 77030
United States
Education
- Postdoctoral Fellowship at 草榴社区入口
- 04/2023 - Houston, Texas United States
- Postdoctoral Fellowship at University of Houston
- 09/2019 - Houston, Texas United States
- Postdoctoral Fellowship at Texas Tech University Health Sciences Center
- 09/2017 - Amarillo, Texas United States
- PhD from Shandong University
- 06/2016 - Jinan, China
Professional Interests
- Drug Discovery, Medicinal Chemistry and Chemical Biology
Professional Statement
I am dedicated to the field of medicinal chemistry and drug discovery, driven by a passion for combating human diseases and improving human health.My academic training encompasses rational and computer-aided drug design, organic chemistry, and drug evaluation/action of mechanism studies with a number of techniques, including recombinant protein expression and purification, various biochemical (such as UV/fluorescence-based and Alpha/ITC/BLI) assays, cell culture, Western blot, CHIP-qPCR, and gene set enrichment analysis. I have got a full set of primary academic trainings in medicinal chemistry and drug discovery.
I have over 10 years of wet lab research experience in medicinal chemistry and drug discovery, and have discovered and developed several kinds of protein inhibitors/degraders (published) including novel antibacterial macrolides targeting bacterial ribosome and cinnamaldehyde analogs targeting FtsZ (2010-2016), anticancer agents targeting MDM2/MDM4 (2016-2019), anticancer agents targeting P300/CBP, AHD and ENL (2019-), and novel antiviral agents against flaviviruses, coronaviruses and noroviruses (2019-). I have gained a wealth of experience, especially in the anti-infective and anticancer drug discovery areas.
These academic training and research experience have provided me with a strong background in the discovery and development of novel chemical probes or drug leads, which could be used for the fundamental biology study or for the further drug development.
Websites
Selected Publications
- Xin Li, Yuan Yao, Fangrui Wu, Yongcheng Song "." J Hematol Oncol. 2022 Apr 8;2022(15):41. Pubmed PMID:
- Md Ashraf-Uz-Zaman #, Xin Li #, Yuan Yao #, Chandra Bhushan Mishra, Bala Krishna Moku, and Yongcheng Song "." J Med Chem. 2023 Jul 28; Pubmed PMID:
- Xin Li, Yongcheng Song "." J Hematol Oncol. 2020 May 13;13:50. Pubmed PMID:
- Xin Li, Yongcheng Song "." J Hematol Oncol. 2021 Apr 6;14(1):56. Pubmed PMID:
- Xin Li #, Yongcheng Song # "." Eur J Med Chem. 2023 Aug 31;260:115772. Pubmed PMID:
- Shenyou Nie*, Fangrui Wu*, Jingyu Wu*, Xin Li*, Chao Zhou, Yuan Yao, Yongcheng Song "." Eur J Med Chem. 2022;237(5):114407. Pubmed PMID:
- Fangrui Wu, Shenyou Nie, Yuan Yao, Tong Huo, Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qianxing Mo, Yongcheng Song "." Theranostics. 2021;11(17):8172-8184. Pubmed PMID:
- Shenyou Nie, Jidong Zhao, Xiaowei Wu, Yuan Yao, Fangrui Wu, Yi-Lun Lin, Xin Li, Alexander R Kneubehl, Megan B Vogt, Rebecca Rico-Hesse, Yongcheng Song "." Eur J Med Chem. 2021 Nov 5;225:113767. Pubmed PMID:
- Xin Li *, Xiaowei Wu *, Shenyou Nie, Jidong Zhao, Yuan Yao, Fangrui Wu, Chandra Bhushan Mishra, Md Ashraf-Uz-Zaman, Bala Krishna Moku, Yongcheng Song "." Cancers. 2023 Nov 3;15(21):5283. Pubmed PMID:
- Xin Li #, Yongcheng Song # "." Drug Discov Today. 2023 Nov 15;29(1):103832. Pubmed PMID:
- Md Ashraf-Uz-Zaman *, Teck Khiang Chua *, Xin Li *, Yuan Yao, Bala Krishna Moku, Chandra Bhushan Mishra, Vasanthi Avadhanula, Pedro A. Piedra, and Yongcheng Song "." ACS Infect Dis. 2024 Jan 8;10(2):715-731. Pubmed PMID:
Funding
- SynthX/Duncan Cancer Center Seed Award Grant funding from SynthX Center and the Duncan Cancer Center
Skills
- Drug design/synthesis, Natural product modification
- Docking, Molecular modeling, Virtual screening
- Drug-screening/-evaluation related biophysical/cellular study (Fluorescence polarization, AlphaLISA/Screen, M/XTT, Western blotting, ChIP, RT-qPCR...
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