Tsz-Kwong Man, Ph.D., B.S.
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Positions
- Associate Professor
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Pediatrics-Oncology
草榴社区入口
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Houston, Texas United States
Education
- Postdoctoral Training at Washington University
- 01/2001 - St. Louis, MO United States
- PhD from University Of Texas Medical School At Houston
- 01/1997 - Houston, Texas United States
- BSc from Hong Kong Baptist College
- 01/1986 - Hong Kong, Hong Kong
Professional Interests
- Research Interests
Professional Statement
Molecular classification of cancer using a systems biology approach. We use a systems biology approach to generate genomic and proteomic profiles from various specimens of cancer patients, such as tumors and plasma. The goal of our laboratory is to integrate these diverse data by various classification algorithms to construct prediction models, which can better predict clinical phenotypes of pediatric cancer, such as drug resistance, metastatic potential, and prognosis. Ultimately, we aim to develop an easy-to-use and minimally invasive blood test that can help to diagnose and prognosticate patients with pediatric cancers, so they can be treated as early and precisely as possible. Mechanistic study of metastatic determinants. Using a proteomic approach, we have identified p27 (CDKN1B) as a crucial metastatic determinant in pediatric osteosarcoma. We have shown that p27 is frequently mislocalized in the cytoplasm of osteosarcoma cases, and the mislocalization increases the metastatic potential of tumor cells. p27 is a well-known tumor suppressor gene that regulates normal cell cycle progression when it is located in the nucleus, but its oncongenic function when located in the cytoplasm is still largely unknown. It may act as a master switch between tumorigenesis and cancer progression. We use a panel of targeted genomic and proteomic methods to dissect the mechanism of the cytoplasmic p27 in the promotion of metastasis in osteosarcoma and other cancers. Our goal is to test if cytoplasmic p27 can be used as a novel therapeutic target to abolish metastasis in cancer. Cancer bioinformatics. With the explosion of the genomic data and the decreasing cost of the genomic assays, there is a wealth of genomic data available in various public repositories. These resources provide an unprecedented opportunity for data mining to identify common cancer signatures and mechanisms in various cancers. Understanding these common features of different types of cancer will provide an important clue on how to target cancer in general. Our lab is interested in developing bioinformatic methods and tools that can utilize these resources to answer specific biological or clinical questions that will lead to a better understanding of common cancer phenotypes and the development of novel therapeutic targets.Websites
Link to VIICTR
Selected Publications
- Flores RJ, Li Y, Yu A, Shen J, Rao PH, Lau SS, Vannucci M, Lau CC, Man TK "." BMC Syst Biol. 2012;6:50. Pubmed PMID:
- Egler RA, Li Y, Dang TA, Peters TL, Leung E, Huang S, Russell HV, Liu H, Man TK "." Proteomics Clin Appl. 2011 Oct;5(41527):532-41. Pubmed PMID:
- Li Y, Flores R, Yu A, Okcu MF, Murray J, Chintagumpala M, Hicks J, Lau CC, Man TK "." Cancer. 2011 Jan 1;117(1):207-17. Pubmed PMID:
- Li Y, Dang TA, Shen J, Hicks J, Chintagumpala M, Lau CC, Man TK "." Oncol. Rep.. 2011 Feb;25(2):303-14. Pubmed PMID:
- Guo B, Villagran A, Vannucci M, Wang J, Davis C, Man TK, Lau C, Guerra R "." BMC Res Notes. 2010;3:350. Pubmed PMID:
- Cruz-Marcelo A, Guerra R, Vannucci M, Li Y, Lau CC, Man TK "." Bioinformatics. 2008 Oct 1;24(19):2129-36. Pubmed PMID:
- Daves MH, Hilsenbeck SG, Lau CC, Man TK "." BMC Med Genomics. 2011;4:56. Pubmed PMID:
- Li Y, Dang TA, Shen J, Perlaky L, Hicks J, Murray J, Meyer W, Chintagumpala M, Lau CC, Man TK "." Proteomics. 2006 Jun;6(11):3426-35. Pubmed PMID:
- Yu L, Baxter PA, Voicu H, Gurusiddappa S, Zhao Y, Adesina A, Man TK, Shu Q, Zhang YJ, Zhao XM, Su JM, Perlaky L, Dauser R, Chintagumpala M, Lau CC, Blaney SM, Rao PH, Leung HC, Li XN "." Neuro-oncology. 2010 Jun;12(6):580-94. Pubmed PMID:
- Wong KK, Tsang YT, Shen J, Cheng RS, Chang YM, Man TK, Lau CC "." Nucleic Acids Res.. 2004;32(9):e69. Pubmed PMID:
- Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL "." J. Immunol.. 2010 Apr 15;184(8):4557-67. Pubmed PMID:
- Gu JX, Wei MY, Rao PH, Lau CC, Behl S, Man TK "." Gene Regul Syst Bio. 2007;1:131-6. Pubmed PMID:
- Dang TA, Man TK "." Curr Pharm Biotechnol. 2007 Apr;8(2):83-91. Pubmed PMID:
- Rabin KR, Man TK, Yu A, Folsom MR, Zhao YJ, Rao PH, Plon SE, Naeem RC "." Pediatr Blood Cancer. 2008 Aug;51(2):171-7. Pubmed PMID:
- Cheung AN, Srivastava G, Pittaluga S, Man TK, Ngan H, Collins RJ "." J. Clin. Pathol.. 1993 Mar;46(3):204-7. Pubmed PMID:
- Cheung AN, Srivastava G, Chung LP, Ngan HY, Man TK, Liu YT, Chen WZ, Collins RJ, Wong LC, Ma HK "." J Reprod Med. 1994 Mar;39(3):223-7. Pubmed PMID:
- Man TK, Chintagumpala M, Visvanathan J, Shen J, Perlaky L, Hicks J, Johnson M, Davino N, Murray J, Helman L, Meyer W, Triche T, Wong KK, Lau CC "." Cancer Res.. 2005 Sep 15;65(18):8142-50. Pubmed PMID:
- Man TK, Lu XY, Jaeweon K, Perlaky L, Harris CP, Shah S, Ladanyi M, Gorlick R, Lau CC, Rao PH "." BMC Cancer. 2004 Aug 7;4:45. Pubmed PMID:
- Yang Y, Tsui HC, Man TK, Winkler ME "." J. Bacteriol.. 1998 Apr;180(7):1814-21. Pubmed PMID:
- Rainusso N, Man TK, Lau CC, Hicks J, Shen JJ, Yu A, Wang LL, Rosen JM "." Cancer Biol. Ther.. 2011 Aug 15;12(4):278-87. Pubmed PMID:
- Yang Y, Zhao G, Man TK, Winkler ME "." J. Bacteriol.. 1998 Aug;180(16):4294-9. Pubmed PMID:
- Man TK, Zhao G, Winkler ME "." J. Bacteriol.. 1996 Apr;178(8):2445-9. Pubmed PMID:
- Man TK, Pease AJ, Winkler ME "." J. Bacteriol.. 1997 Jun;179(11):3458-69. Pubmed PMID:
- De Bortoli M, Castellino RC, Lu XY, Deyo J, Sturla LM, Adesina AM, Perlaky L, Pomeroy SL, Lau CC, Man TK, Rao PH, Kim JY "." BMC Cancer. 2006;6:223. Pubmed PMID:
- Ma O, Cai WW, Zender L, Dayaram T, Shen J, Herron AJ, Lowe SW, Man TK, Lau CC, Donehower LA "." Cancer Res.. 2009 Mar 15;69(6):2559-67. Pubmed PMID:
- Man TK, Stormo GD "." Nucleic Acids Res.. 2001 Jun 15;29(12):2471-8. Pubmed PMID:
- Man TK, Li Y, Dang TA, Shen J, Perlaky L, Lau CC "." Proteome Sci. 2006;4:3. Pubmed PMID:
- De Bortoli M, Castellino RC, Skapura DG, Shen JJ, Su JM, Russell HV, Hicks MJ, Man TK, Kim JY "." Eur. J. Cancer. 2007 May;43(8):1308-17. Pubmed PMID:
- Rabin K, Man TK, Lau CC "." 2008;62:173-85; discuss. Pubmed PMID:
- Li Y, Dang TA, Man TK "." Methods Mol. Biol.. 2012;818:81-96. Pubmed PMID:
- Man TK, Yang JS, Stormo GD "." Nucleic Acids Res.. 2004;32(13):4026-32. Pubmed PMID:
- Harris ZL, Durley AP, Man TK, Gitlin JD "." Proc. Natl. Acad. Sci. U.S.A.. 1999 Sep 14;96(19):10812-7. Pubmed PMID:
Projects
- Identification of blood-based biomarkers for ostesosarcoma
- CPRIT
- Examination of the prognostic significance of p27 in osteosarcoma
Memberships
- Children's Oncology Group
- Associate Member
- American Assoication for Cancer Research
- Member
Funding
- Harnessing P27 for Prognostication of Pediatric Osteosarcoma - #1R01HD074553 (01/01/2013 - 12/31/2015) Grant funding from NIH/NICHD
- Targeted Therapies for Metastatic Osteosarcoma - #RP140022-P2 (08/01/2010 - 02/29/2016) Grant funding from Cancer Prevention and Research Institute of Texas
- Targeting the CXCL10-CXCR3 axis in metastatic osteosarcoma
- $1,200,000.00 (08/31/2020 - 08/30/2024) Grant funding from Cancer Prevention and Research Institute of Texas
Skills
- Bioinformatics
- Cancer Research
- Genomics and Proteomics
Languages
Chinese (Cantonese)
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