Thomas Garcia, PhD, HCLD (ABB)
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Positions
- Assistant Professor
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Department of Pathology & Immunology
草榴社区入口
- Assistant Professor
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Scott Department of Urology
草榴社区入口
- Clinical Laboratory Director
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Advanced Reproductive And Urologic Procedures Laboratory
Scott Department of Urology
草榴社区入口
- Clinical Laboratory Director
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Special Procedures Laboratory
Scott Department of Urology
草榴社区入口
- Clinical Laboratory Director
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Sperm Bank
Scott Department of Urology
草榴社区入口
Education
- BS from Florida State University
- 08/2003 - Tallahassee, Florida United States
- PhD from University of Illinois at Urbana-Champaign
- 05/2009 - Urbana, Illinois United States
- Postdoctoral Fellowship at University of Texas MD Anderson Cancer Center
- 08/2012 - Houston, Texas United States
Certifications
- High-complexity Clinical Laboratory Director (HCLD)
- American Board of Bioanalysis (ABB)
Professional Interests
- Identifying new genetic causes of male infertility
- Elucidating the molecular mechanisms underlying sperm development, maturation, and function
- Investigating novel male reproductive tract-specific genes as contraceptive targets
Websites
The original Mammalian Reproductive Genetics Database (MRGD) was initially established by Dr. Robert Braun at the University of Washington in 1997 to host microarray-based gene expression data from many male and female reproductive tissue and cell studies. Through generous funding from the Male Contraceptive Initiative and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Garcia laboratory has developed the MRGDv2 as a modern-day iteration of the MRGD with the intent to disseminate more recent RNA sequencing-based gene expression data from male and female, human and mouse, reproductive and non-reproductive tissues and cells. In total, the MRGDv2 contains data from approximately 1,000 published bulk RNAseq datasets, all reprocessed in parallel through a custom bioinformatics pipeline to allow for cross-comparison of the data. As hosted on the website, the visualizations can be used to glean insight into the tissue or cell-specific expression of any queried gene, with the orthologous species' result(s) displayed side-by-side. Investigators using the website can customize the appearance and order of tissues and cells using the 'Customize Parameters' tool, and, when available, visualize the microarray-based expression data formerly on the original MRGD, along with receive insight into whether and which prior studies had previously identified the queried gene(s) as male reproductive tract-specific. HTML5 coding and server hosting efforts were led by Drs. Uma Ramamurthy and Vivek Ramanathan in the Office of Research Information Technology at 草榴社区入口.
Selected Publications
- Kent K, Nozawa K, Parkes R, Dean L, Daniel F, Leng M, Jain A, Malovannaya A, Matzuk MM, and Garcia TX "." Proc Natl Acad Sci. 2024 Dec 12;121(51)
- Garcia TX, Matzuk MM "." Mol Reprod Dev. 2024 Oct;91(10) Pubmed PMID:
- Parkes R and Garcia TX "." Expert Rev Proteomics. 2024 Apr;21(4):181-203. Pubmed PMID:
- Kent K, Nozawa K, Sutton C, Daniel F, Ikawa M, Garcia TX, Matzuk MM "." Andrology. 2024 Mar;12(3):682-697. Pubmed PMID:
- Suzuki A, Yabuta N, Shimada K, Mashiko D, Tokuhiro K, Oyama Y, Miyata H, Garcia TX, Matzuk MM, Ikawa M "." J Reprod Immunol. 2024 Jun;163 Pubmed PMID:
- Tan Z and Garcia TX "." PNAS. 2023 Feb 15;120(8):e2221758120.
- Sutton C, Nozawa K, Kent K, Saltzman A, Leng M, Nagarajan S, Malovannaya A, Ikawa M, Garcia TX, Matzuk MM "." Sci Rep. 2023 Jul 14;13(1):11374. Pubmed PMID:
- Nozawa K, Garcia TX, Kent K, Leng M, Jain A, Malovannaya A, Yuan F, Yu Z, Ikawa M, Matzuk MM "." Andrology. 2023 Jul;11(5):826-839. Pubmed PMID:
- Nozawa K, Fujihara Y, Devlin DJ, Deras RE, Kent K, Larina IV, Umezu K, Yu Z, Sutton CM, Ye Q, Dean LK, Emori C, Ikawa M, Garcia TX, Matzuk MM "." BMC Biol. 2022 Jul 13;20(1):161. Pubmed PMID:
- Oyama Y, Miyata H, Shimada K, Fujihara Y, Tokuhiro K, Garcia TX, Matzuk MM, Ikawa M "." Asian J Androl. 2021 Jul 16; Pubmed PMID:
- Robertson MJ, Kent K, Tharp N, Nozawa K, Dean L, Mathew M, Grimm SL, Yu Z, L茅gar茅 C, Fujihara Y, Ikawa M, Sullivan R, Coarfa C, Matzuk MM, Garcia TX "." BMC Biol. 2020 Aug 19;18(1):103. Pubmed PMID:
- Kent K, Johnston M, Strump N, and Garcia TX "." Front Cell Dev Biol. 2020 Feb 26;
- Holcomb RJ, Oura S, Nozawa K, Kent K, Yu Z, Robertson MJ, Coarfa C, Matzuk MM, Ikawa M, Garcia TX "." Biol Reprod. 2020 Feb 12;102(1):84-91. Pubmed PMID:
- Sun J, Lu Y, Nozawa K, Xu Z, Morohoshi A, Castaneda JM, Noda T, Miyata H, Abbasi F, Shawki HH, Takahashi S, Devlin DJ, Yu Z, Matzuk RM, Garcia TX, Matzuk MM, Ikawa M "." Biol Reprod. 2020 Aug 4;103(2):183-194. Pubmed PMID:
- Park S, Shimada K, Fujihara Y, Xu Z, Shimada K, Larasati T, Pratiwi P, Matzuk RM, Devlin DJ, Yu Z, Garcia TX, Matzuk MM, Ikawa M "." Biol Reprod. 2020 Aug 4;103(2):195-204. Pubmed PMID:
- Parekh PA, Garcia TX, Waheeb R, Jain V, Gandhi P, Meistrich ML, Shetty G, Hofmann MC "." FASEB J. 2019 Apr 16;fj201802361R. Pubmed PMID:
- Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D, Zhang Q, Larasati T, Young SAM, Kodani M, Robertson MJ, Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX, Ikawa M "." Biol Reprod. 2019 Aug 1;101(2):501-511. Pubmed PMID:
- Parekh P, Garcia TX, Hofmann MC "." Reproduction. 2019 Jan 1;pii: REP-18-0239.R2. Pubmed PMID:
- Garcia TX, Parekh P, Kow S, Hofmann MC "." Stem Cells Dev. 2017 Apr 15;26(8):585-598. Pubmed PMID:
- Garcia TX, Farmaha JK, Kow S, Hofmann MC "." Development. 2014 Dec;141(23):4468-78. Pubmed PMID:
- Garcia TX, Costa GMJ, Fran莽a LR, Hofmann MC "." Reprod Toxicol. 2014 Jun;45:59-70. Pubmed PMID:
- Garcia TX, Hofmann MC "." Cell Cycle. 2013 Aug 15;12(16):2538-45. Pubmed PMID:
- Garcia TX, DeFalco T, Capel B, Hofmann MC "." Dev Biol. 2013 May 1;377(1):188-201. Pubmed PMID:
- Garcia T, Hofmann MC "." Methods Mol Biol. 2012;825:31-44. Pubmed PMID:
- Lin Z, Witschas K, Garcia T, Chen RS, Hansen JP, Sellers ZM, Kuzmenkina E, Herzig S, Best PM "." J Physiol. 2008 Nov 15;586(22):5349-66. Pubmed PMID:
Memberships
- Society for the Study of Reproduction
- Member
- American Society for Human Genetics
- Member
- American Urological Association
- Member
- American Association of Bioanalysts
- Member
Funding
- Search for new genes involved in male infertility through novel approaches - #R01 HD106056 (02/22/2022 - 11/30/2026) Grant funding from National Institutes of Health
- Third-generation sequencing of infertile men to confirm male contraceptive target feasibility (02/01/2022 - 01/31/2024) Grant funding from Male Contraceptive Initiative
- Mammalian Reproductive Genetics Database V2 (05/01/2021 - 04/30/2022) Grant funding from Male Contraceptive Initiative
- Functional genomics and proteomics to reveal reproductive-tract specific proteins - #R01 HD095341 (04/01/2018 - 03/31/2021) Grant funding from National Institutes of Health
Intellectual Property
- Method Patent #US 8,299,211 B2 (Approved)
- This method and composition patent discloses methods and compositions involving short peptides capable of regulating calcium channel function, particularly for applications in modulating calcium current in mammalian cells. The patent includes embodiments of peptides, nucleic acids encoding these peptides, and pharmaceutical compositions for therapeutic use.
- Co Inventors: Philip M. Best, Ren-Shiang Chen, Zuojun Lin, Thomas Garcia
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