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Email

spangas@bcm.edu

Positions

Professor

Pathology
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Houston, TX

Roger Rossen Endowed Professorship of Reproductive Pathology

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Education

Post-Doctoral Fellowship at Baylor College Of Medicine

01/2007 - Houston, Texas United States

Reproductive Biology

PhD from Northwestern University

04/2002 - Evanston, Illinois United States

Neurobiology and Physiology

MS from Northwestern University

06/1995 - Evanston, Illinois United States

Biochemistry, Molecular Biology, and Cell Biology

BA from Kent State University

06/1990 - Kent, Ohio United States

Anthropology and Sociology

Professional Interests

• Reproductive Biology
• Reproductive Cancers

Professional Statement

Twenty percent of women’s health problems worldwide are attributed to reproductive and sexual health issues. Disruptions in normal reproductive function cause health problems that extend beyond infertility, and include increases in cardiovascular disease, osteoporosis, and cognitive disorders. Furthermore, ovarian cancer is the most lethal gynecologic malignancy in women. In part, this is due to a lack of diagnostics needed for early detection. Therefore, the origin, diagnosis, and treatment of gynecological diseases are critical health issues that need to be addressed.
Our research laboratory focuses on understanding how the ovary normally develops and functions, and how defects in these processes result in reproductive disorders and cancer development. We use a multifaceted approach, generating data from patient samples, immortalized cancer cell lines, and genetically modified mice. Since the laboratory has started in 2007, our research has contributed a number of key mouse models for genes that cause infertility, ovarian dysfunction, and ovarian cancer. These models are paramount in the search for novel therapeutics and diagnostics for patients with reproductive diseases.

Websites

Selected Publications

• Rodriguez A, Briley SM, Patton BK, Tripurani SK, Rajapakshe K, Coarfa C, Rajkovic A, Andrieux A, Dejean A, Pangas SA "." Development. 2019 Dec 2;146(23) Pubmed PMID:
• Richards JS, Pangas SA "." J. Clin. Invest.. 2010 Apr 1;120(4):963-72. Pubmed PMID:
• Middlebrook BS, Eldin K, Li X, Shivasankaran S, Pangas SA "." Endocrinology. 2009 Dec;150(12):5208-17. Pubmed PMID:
• Myers M, Middlebrook BS, Matzuk MM, Pangas SA "." Dev. Biol.. 2009 Oct 15;334(2):458-67. Pubmed PMID: