Positions
- Professor
-
Molecular and Human Genetics
草榴社区入口
Houston, TX US
- Assistant Laboratory Director
-
Cytogenetics Laboratory
Baylor Genetics
Education
- MD from Aga Khan University Medical College
- 01/1994 - Karachi, Pakistan
- Residency at Milton S Hershey Medical Center
- 01/1996 - Hershey, Pennsylvania United States
- Pediatrics
- Clinical Fellowship at Baylor College Of Medicine
- 01/1999 - Houston, TX United States
- Medical Genetics
- Clinical Fellowship at Baylor College Of Medicine
- 01/2004 - Houston, Texas United States
- Clinical Cytogenetics
Certifications
- General Pediatrics
- American Board of Pediatrics
- Clinical Genetics
- American Board of Medical Genetics
- Clinical Cytogenetics
- American Board of Medical Genetics
Professional Interests
- Copy number variations and diseases, congenital cardiovascular malformations, genetic causes of language/speech delay
Professional Statement
My work has focused on understanding the molecular basis of neurodevelopmental and cardiovascular disorders in the pediatric population. We have used molecular cytogenetic diagnostic tools such as chromosomal microarray analysis (CMA) and exome sequencing (ES) in understanding the genetic basis of birth defects. We have also studied the clinical utility of rapid ES in neonatal intensive care units. I have been involved with the Undiagnosed Diseases Network (UDN) study at 草榴社区入口 for several years and helped characterize diagnoses in multiple undiagnosed children with rare diseases. Using ES, we have identified several novel Mendelian disorders responsible for neurodevelopmental disorders in the pediatric population. In 2016, we first described a cohort of patients with TANGO2 disease and are currently recruiting families in the natural history study.Websites
Selected Publications
- Coban-Akdemir ZH, Charng WL, Azamian M, Paine IS, Punetha J, Grochowski CM, (...), Lupski JR, Lalani SR "." Am J Med Genet A. 2020 Jun;182(6):1387-1399. Pubmed PMID:
- Lalani SR "." Am J Med Genet C Semin Med Genet. 2020 Mar;184(1):107-115. Pubmed PMID:
- Lalani SR, Graham B, Burrage L, Lai YC, Scaglia F, Soler-Alfonso C, Miyake CY, Yang Y "." 骋别苍别搁别惫颈别飞蝉庐. 2018 Jan 25; Pubmed PMID:
- Meng L, Pammi M, Saronwala A, Magoulas P, (...), Shaw C, Walkiewicz M, Bi W, Xia F, Lee B, Eng CM, Yang Y, Lalani SR "Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management.." JAMA Pediatr.. 2017;171:e173438.
- Lalani SR, Liu P, Rosenfeld JA, Watkin LB, (...), Yang Y "Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations.." Am J Hum Genet.. 2016;98:347-57.
- Burrage LC, Charng WL, Eldomery MK, (...), Lalani SR, Lupski JR, Bongers EM, Yang Y "De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome.." Am J Hum Genet.. 2015;97:904-13.
- Probst FJ, James RA, Burrage LC, Rosenfeld JA, Bohan TP, Ward Melver CH, Magoulas P, Austin E, Franklin AI, Azamian M, Xia F, Patel A, Bi W, Bacino C, Belmont JW, Ware SM, Shaw C, Cheung SW, Lalani SR "." Orphanet J Rare Dis.. 2015 Jun 14;10:75. Pubmed PMID:
- Szafranski P, Von Allmen GK, Graham BH, Wilfong AA, Kang SH, Ferreira JA, Upton SJ, Moeschler JB, Bi W, Rosenfeld JA, Shaffer LG, Wai Cheung S, Stankiewicz P, Lalani SR "." Eur J Hum Genet. 2015 Feb;23:173-9. Pubmed PMID:
- Parrott A, James J, Goldenberg P, Hinton RB, Miller E, Shikany A, Aylsworth AS, Kaiser-Rogers K, Ferns SJ, Lalani SR, Ware SM "." Am J Med Genet A. 2015 Feb;167:363-70. Pubmed PMID:
- Lalani SR, Belmont JW "." Eur J Med Genet. 2014 Aug;57(8):402-13. Pubmed PMID:
- Lalani SR, Zhang J, Schaaf CP, Brown CW, Magoulas P, ..., Eng CM, Lupski JR, Gibbs RA, Beaudet AL, Yang Y, Wang MC, Xia F "." Am J Hum Genet. 2014 Nov 6;95:579-83. Pubmed PMID:
- Lalani SR, Ware SM, Wang X, Zapata G, ..., Fernbach SD, Potocki L, Belmont JW "." Hum Mol Genet.. 2013 1;22(21):4339-48. Pubmed PMID:
- Wiszniewski W, Hunter JV, Hanchard NA, Willer JR, Shaw C, Tian Q, Illner A, Wang X, (.....), Lalani SR "." Am J Hum Genet.. 2013 Aug 8;93(2):197-210. Pubmed PMID:
- Lalani SR, Shaw C, Wang X, Patel A, Patterson LW, Kolodziejska K, Szafranski P, Ou Z, Tian Q, Kang SH, Jinnah A, Ali S, Malik A, Hixson P, Potocki L, Lupski JR, Stankiewicz P, Bacino CA, Dawson B, Beaudet AL, Boricha FM, Whittaker R, Li C, Ware SM, Cheung "." Eur. J. Hum. Genet.. 2013 Feb;21(2):173-81. Pubmed PMID:
- Lalani SR, Hefner MA, Belmont JW, Davenport SLH "." In: Pagon RA, Adam MP, Ardinger HH, Wallace S. 2012 Feb 2; Pubmed PMID:
- Liu P, Erez A, Nagamani SC, Dhar SU, Kolodziejska KE, Dharmadhikari AV, Cooper ML, Wiszniewska J, Zhang F, Withers MA, Bacino CA, Campos-Acevedo LD, Delgado MR, Freedenberg D, Garnica A, Grebe TA, Hern谩ndez-Almaguer D, Immken L, Lalani SR, McLean SD, Nort "." Cell. 2011 Sep 16;146(6):889-903. Pubmed PMID:
- Layman WS, McEwen DP, Beyer LA, Lalani SR, Fernbach SD, Oh E, Swaroop A, Hegg CC, Raphael Y, Martens JR, Martin DM "." Hum. Mol. Genet.. 2009 Jun 1;18(11):1909-23. Pubmed PMID:
- Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansman "." J. Med. Genet.. 2009 Mar;46(3):168-75. Pubmed PMID:
- Brunetti-Pierri N, Berg JS, Scaglia F, Belmont J, Bacino CA, Sahoo T, Lalani SR, Graham B, Lee B, Shinawi M, Shen J, Kang SH, Pursley A, Lotze T, Kennedy G, Lansky-Shafer S, Weaver C, Roeder ER, Grebe TA, Arnold GL, Hutchison T, Reimschisel T, Amato S, Ge "." Nat. Genet.. 2008 Dec;40(12):1466-71. Pubmed PMID:
- Lalani SR, Safiullah AM, Fernbach SD, Harutyunyan KG, Thaller C, Peterson LE, McPherson JD, Gibbs RA, White LD, Hefner M, Davenport SL, Graham JM, Bacino CA, Glass NL, Towbin JA, Craigen WJ, Neish SR, Lin AE, Belmont JW "." Am. J. Hum. Genet.. 2006 Feb;78(2):303-14. Pubmed PMID:
Memberships
- Society of Pediatric Research
- Member
- American Society of Human Genetics
- Member
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