Sandesh C.S. Nagamani, M.B.B.S, M.D., FACMG
Picture
Positions
- Professor
-
Molecular and Human Genetics
草榴社区入口
Houston, TX US
- Vice Chair, Clinical Research Affairs
-
Molecular and Human Genetics
草榴社区入口
- Professor
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Department of Medicine
草榴社区入口
- Director
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BCM Intellectual and Developmental Disabilities Research Center
草榴社区入口
- Director
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BCM Intellectual and Developmental Disabilities Research Center
Clinical Translational Core
Addresses
- Adult Genetics Clinic (Clinic)
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草榴社区入口 Medical Center - McNair Campus
7200 Cambridge St.
Houston, TX 77030
United States
Phone: (713) 798-7820
Adult Genetics Clinic
Education
- Residency at Baylor College Of Medicine
- 10/2009 - Houston, Texas United States
- Internal Medicine
- Postdoctoral Training at Baylor College Of Medicine
- 06/2009 - Houston, Texas United States
- Clinical Genetics
- Residency at Baylor College Of Medicine
- 06/2008 - Houston, Texas United States
- Clinical Genetics
- Residency at Fairview Hospital, A Cleveland Clinic Hospital
- 06/2006 - Cleveland, Ohio United States
- Residency at Gandhi Medical College
- 01/2003 - Bhopal, India
- Internal Medicine
- MBBS from University of Mysore
- 01/1999 - Mysore, India
- Medical School
Certifications
- American Board of Medical Genetics and Genomics
- American Board of Internal Medicine
Honors & Awards
- Rising Star Award
- 草榴社区入口 (05/2015)
- Norton Rose Fulbright Faculty Excellence Award for Teaching and Evaluation
- 11/2016
- Norton Rose Fulbright Faculty Excellence Award for Creation of Enduring Materials
- 05/2021
- Member, Academy of Distinguished Educators at BCM
- Clark Faculty Service Award
- BCM (05/2023)
- Adult Genetics Excellence in Education Award
- 2012, 2013, 2015, 2016, 2022
- Department of Molecular and Human Genetics, 草榴社区入口
- Doris Duke Foundation Paragon Award for Research Excellence
- 10/2023
Professional Statement
My research is focused on translational medicine, specifically, evaluating novel potential therapies for various genetic disorders. The main focus of my research program is clinical investigation including conducting natural history studies, proof-of-concept pilot studies, and interventional clinical trials in patients with inborn errors of metabolism and genetic skeletal disorders. I am fortunate to be the Director for the Clinical Research Division of the Department of Molecular and Human Genetics that conducts over 50 clinical studies in various genetic disorders.Inborn Errors of Metabolism: I serve as a Co-Principal Investigator for the NIH Rare Diseases Clinical Research Network鈥檚 (RDCRN's) Urea Cycle Disorders Consortium (UCDC), an international consortium comprising 16 sites in the U.S., Canada, and Europe. The longitudinal, observational, natural history study conducted by the UCDC has collectively enrolled over 900 individuals in this ultra rare disorder. I am actively involved in conducting natural history studies, data-mining projects and exploratory studies aimed at improving therapies for UCDs. As the PI for the Pilot/Feasibility core of the consortium, I am involved in facilitating projects that will develop and validate new biomarkers for disease activity and endpoints that can be used in clinical investigation. As the PI for the Career Enhancement Core for the consortium, I am glad to be a cheerleader for the career advancement of young investigators in the field of inborn errors of metabolism.
Skeletal dysplasia: I am a lead investigator of the NIH Rare Diseases Clinical Research Network鈥檚 Brittle Bone Disorders Consortium. I have contributed significantly to the natural history studies of osteogenesis imperfecta, the most common osteodysplasis in humans. I have developed clinical endpoints and biomarkers to assess disease burden from the perspective of clinical trial readiness and have had lead roles in clinical trials evaluating novel therapies for OI including the first disease-specific therapy with anti-transforming growth factor beta antibody. I serve as the site PI at BCM for clinical trials in genetic skeletal disorders that are sponsored by the pharmaceutical industry.
Intellectual and Developmental Disabilities: I serve as the PI and Director for the NICHD-funded Intellectual and Developmental Disabilities Research Center at BCM. Our center supports core facilities that facilitates the translational research activities of more than 80 investigators engaged in advancing research and clinical care for individuals with intellectual and developmental disabilities.
Clinical Interests: As an internist and adult clinical geneticist, I provide care to adults with a wide variety of heritable conditions. As the Director of the Clinic for Metabolic and Genetic disorders of bone, I evaluate and treat patients with osteogenesis imperfecta, heritable disorders of bone, IDD, Mendelian forms of cancer and heritable connective tissue disorders.
Educational Activities: On the educational front, I have been heavily involved in patient-outreach activities and education of young investigators, medical students, graduate trainees, and clinical residents. I have also been actively involved in developing resources for education of families and physicians across our country about specific rare disorders. I have worked with TeleECHO program to implement and deliver virtual training materials to patients and providers. The latter project has used guided-practice model to reduce health disparities in under-served and remote areas through innovative tele-mentoring.
Websites
Selected Publications
- "." ;
- Song IW*, Nagamani SC*, Nguyen D, Grafe I, Sutton VR, Gannon FH, Munivez E, Jiang MM, Tran A, Wallace M, Esposito P, Musaad S, Strudthoff E, McGuire S, Thornton M, Shenava V, Rosenfeld S, Shypailo R, Orwoll E, Lee B "." J Clin Invest. 2022;132:e152571. Pubmed PMID:
- Murali CN, Cuthbertson D, Slater B, Nguyen D, Turner A, Harris G, Sutton VR, Lee B, Members of the BBDC, Nagamani SCS. "." Genet Med. 2020;22:581-589. Pubmed PMID:
- Lee JS, Adler L, Karathia H, Carmel N, Rabinovich S, (...), Nagamani SCS, Unda M, Wilson DM 3rd, Elhasid R, Carracedo A, Samuels Y, Hannenhalli S, Ruppin E, Erez A "." Cell. 2018;174:1559-1570.e22. Pubmed PMID:
- Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH "." Am J Hum Genet.. 2018;103:276-287. Pubmed PMID:
- Nagamani SCS, Agarwal U, Tam A, Azamian M, McMeans A, Didelija IC, Mohammad MA, Marini JC "." Genet Med.. 2018;20:708-716. Pubmed PMID:
- Jain M, Tam A, Shapiro JR, Steiner RD, Smith PA, (...), Members of the Brittle Bone Disorders Consortium*, Nagamani SCS "." Genet Med.. 2018;21:275-283. Pubmed PMID:
- Marini JC, Agarwal U, Didelija IC, Azamian M, Stoll B, Nagamani SC "." J Nutr.. 2017;147:549-555.. Pubmed PMID:
- Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D, Korman S, Itzkovitz S, Dimmock D, Igor Ulitsky, Nagamani SC, Ruppin E and Erez A "." Nature. 2015 Nov;527(7578):379-83. Pubmed PMID:
- Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B "." Nat Med. 2011 Nov 13;17(12):1619-26. Pubmed PMID:
- Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B "." Am J Hum Genet. 2012 May 4;90(5):836-46. Pubmed PMID:
- Orwoll ES, Shapiro J, Veith S, Wang Y, Lapidus J, Vanek C, Reeder JL, Keaveny TM, Lee DC, Mullins MA, Nagamani SC, Lee B "." J Clin Invest. 2014 Feb 3;124(2):491-8. Pubmed PMID:
- Nagamani SC, Shchelochkov OA, Mullins MA, Carter S, Lanpher BC, Sun Q, et al "." Mol Genet Metab. 2012 Nov;107(3):315-21. Pubmed PMID:
- Liu P, Erez A, Nagamani SC, Dhar SU, Ko艂odziejska KE, Dharmadhikari AV, et al "." Cell. 2011 Sep 16;146(6):889-903. Pubmed PMID:
- Bellur S, Jain M, Cuthbertson D, Krakow D, Shapiro JR, Steiner RD, Smith PA, Bober MB, Hart T, Krischer J, Mullins MA, Byers PH, Pepin M, Durigova M, Glorieux FH, Rauch F, Sutton VR, Lee B, 鈥淢embers of the BBD Consortium鈥, and SC Nagamani "." Genetics in Medicine. 2016 Oct;18:570-6. Pubmed PMID:
Memberships
- Rolanette and Berdon Lawrence Bone Disease Program of Texas
- Member
- American College of Medical Genetics
- Elected Fellow
- American Society for Bone and Mineral Research
- Member
- American Society of Human Genetics
- Member
Funding
- Co-Principal Investigator for the NIH RDCRN's Urea Cycle Disorders Consortium - #U54HD061221 (08/01/2014 Grant funding from NCATS, NICHD, NIDDK for the RDCRN
- Principal Investigator, Clinical Translational Core, IDDRC - #P50HD103555 (08/01/2019 Grant funding from NICHD
- Nitric Oxide And Bone Homeostasis In Patients With Argininosuccinate Lyase Deficiency - #R01AR071741 (04/01/2017 Grant funding from NIAMS
- U54 Career Enhancement Core, Brittle Bone Disorders Consortium - #AR068069 (08/01/2019 Grant funding from NCATS, NIAMS, NIDCR, NIHMS, NICHD for the RDCRN
- Intellectual and Developmental Disabilities Research Center - #P50 HD103555 ( Grant funding from NICHD
- PI
- Career Enhancement Core - #U54 HD061221 ( Grant funding from NCATS, NICHD, NIDDK for the RDCRN
- Pilot Feasibility Core - #U54 HD061221 ( Grant funding from NCATS, NICHD, NIDDK
Languages
Hindi, Kannada
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