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Email

pyi@bcm.edu

Positions

Assistant Professor

Mol & Cell Biology-Mol.Regulation
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Houston, TX US

Member

Dan L Duncan Comprehensive Cancer Center
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Houston, Texas United States

Education

Advanced Training from Baylor College Of Medicine

01/2008 - Houston, TX United States

Ph.D. from University Of Rochester

01/2002 - Rochester, NY United States

Professional Interests

• Cancer Biology, Nuclear receptor structure and function, Cell signaling

Professional Statement

My lab research has been focused on molecular regulation of oncogene activation in cancer, with a particular focus on post-translational modification and signal transduction pathways, and nuclear receptor structural studies. Current studies aim to explore the role of non-proteolytic ubiquitination in prostate and lung cancer development and progression. We employ diverse tools for the studies, including transgenic mouse models, PDX tumor models and a variety of molecular biology and cell biology tools. Another interest of the lab is to understand the structure and function of nuclear receptor-coregulator complexes. We are the first group to use cryo electron microscopy (Cryo-EM) to determine the quaternary structure of DNA-bound estrogen receptor alpha, Steroid Receptor Coactivator (SRC-3) and a secondary coactivator (p300) complex. Combining cryo-EM structural approach and biochemical analysis, we have elucidated a series of nuclear receptor complex structures.

Websites

Selected Publications

• Yu, W., Singh, R., Wang, Z., O'Malley, B. W., Yi, P. "." J. Biol. Chem.. 2021;296:100739. Pubmed PMID:
• Yi, P., Wang, Z., Feng, Q., Pintilie, G. D., Foulds, C. E., Lanz, R. B., Ludtke, S. J., Schmid, M. F., Chiu, W., O’Malley, B. W. "." Mol. Cell. 2015;57:1047-1058. Pubmed PMID:
• Singh, R., Karri, D., Shen, H., Shao, J., Dasgupta, S., Huang, S., Edwards, D.P., Ittmann, M.M., O'Malley, B.W., Yi, P. "." J. Clin. Invest.. 2018;128:3129-3143. Pubmed PMID:
• Yi, P., Wang, Z., Feng, Q., Chou C. K., Pintilie, G. D., Shen, H., Foulds, C. E., Fan, G., Serysheva, I., Ludtke, S. J., Schmid, M. F., Hung, M. C., Chiu, W., O'Malley, B. W. "." Mol. Cell. 2017;67:733-743. Pubmed PMID: