Pengxiang Huang, Ph.D.
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Pengxiang Huang, Ph.D.
Assistant Professor & CPRIT Scholar in Cancer Research
Positions
- Assistant Professor & CPRIT Scholar in Cancer Research
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Molecular and Cellular Biology
草榴社区入口
Houston, Texas US
Education
- PhD from University of Virginia
- 12/2009 - Charlottesville, Virginia United States
- BS from Tsinghua University
- 07/2002 - Beijing, China
Honors & Awards
- CPRIT Scholar in Cancer Research
- Cancer Prevention Research Institute of Texas (CPRIT) (08/2020 - 08/2025)
Professional Interests
- Hedgehog signaling, Wnt signaling, Lipids, Biochemistry, Cell biology, Chemical biology, Structural biology
Professional Statement
My research is focused on elucidating the mechanisms of signal transduction in the Hedgehog and Wnt pathways, which are fundamental for embryonic development, adult stem cell maintenance and in many human cancers. I have been broadly trained in cell signaling, biochemistry, chemical and structural biology, including both X-ray crystallography and Cryo-EM. By combining these multidisciplinary approaches, I identified cholesterol as the endogenous activator for Smoothened (SMO), the key signal transducer and oncoprotein in the Hedgehog pathway (Cell. 166:1176-87). I also determined the crystal structures of sterol-bound SMO, demonstrating for the first time the active conformation of a class F GPCR (Cell. 174:312-24). This work together builds the foundation for our current studies aimed at dissecting Hedgehog signaling through SMO, and to expand the scope of our research to study signal transduction in the related Wnt pathway by employing similar strategies. Our long-term goal to leverage this information to devise novel and better therapeutics for cancers associated with these two pathways.Websites
Selected Publications
- Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A. "." Cell. 2018 Jul 12;174(2):312-324. Pubmed PMID:
- Huang P, Nedelcu D, Watanabe M, Jao C, Kim Y, Liu J, Salic A. "." Cell. 2016 Aug 25;166(5):1176-1187. Pubmed PMID:
- Santori FR, Huang P, van de Pavert SA, Douglass EF Jr., Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konijn T, Rosales BN, Rozman D, Horvat S, Rahier A, Mebius RE, Rastinejad F, Nes WD, Littman DR. "." Cell Metab. 2015 Feb 3;21(2):286-298. Pubmed PMID:
- Chandra V, Huang P, Potluri N, Wu D, Kim Y, Rastinejad F. "." Nature. 2013 Mar 21;495(7441):394-398. Pubmed PMID:
- Huh JR, Leung MW#, Huang P#, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. "." Nature. 2011 Apr 28;472(7344):486-490. Pubmed PMID:
- Chandra V#, Huang P#, Hamuro Y, Raghuram S, Wang Y, Burris TP, Rastinejad F. "." Nature. 2008 Nov 20;456(7220):350-356. Pubmed PMID:
- Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, Burris LL, Khorasanizdeh S, Burris TP, Rastinejad F. "." Nat Struc Mol Biol. 2007 Dec;14(12):1207-1213. Pubmed PMID:
- de Almeida Magalhaes T, Liu J, Chan C, Borges KS, Zhang J, Kane AJ, Wierbowski BM, Ge Y, Liu Z, Mannam P, Zeve D, Weiss R, Breault DT, Huang P, Salic A. "." Dev Cell. 2024 Jan 22;59(2):244-261. Pubmed PMID:
- Huang P, Wierbowski BM, Lian T, Chan C, Garc铆a-Linares S, Jiang J, Salic A. "." Dev Cell. 2022 Mar 14;57(5):670-685. Pubmed PMID:
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