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Email

paul.ling@bcm.edu

Positions

Professor

Virol & Micro: Ling
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Houston, TX US

Member

Dan L Duncan Comprehensive Cancer Center
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Houston, Texas United States

Education

Postdoctoral Fellowship at Johns Hopkins University School Of Medicine

Baltimore, MD United States

PhD from USUHS F. Edward Hebert School Of Medicine

Bethesda, MD United States

BA from St. Olaf College

Northfield, Minnesota United States

Honors & Awards

Graduated Cum Laude

St. Olaf College

National Research Service Award for individual postdoctoral fellows

Leukemia Society of America Special Fellow Award

Secretary

Epstein-Barr Virus Association (01/2006 - 01/2013)

Certificate of Appreciation

Elephant Managers Association (EMA)

Associate Editor

PLOS Pathogens

Member

American Cancer Society peer review group (Microbial Pathogenesis and Cancer; MPC) 2010-2015

Chair

American Cancer Society peer review group (Microbial Pathogenesis and Cancer; MPC) 2013-2015

Executive committee EEHV Advisory Group

EEHV Advisory group

Professional Interests

• Elephant Endotheliotropic Herpesvirus (EEHV)
• Gammaherpesvirus pathogenesis

Professional Statement

The Ling laboratory investigates herpesviruses in humans and animals, with a focus over the last 10 years on Elephant Endotheliotropic Herpesvirus (EEHV). EEHV can cause lethal hemorrhagic disease, particularly in juvenile Asian elephants. It is the leading cause of death in juvenile Asian elephants in North America and Europe and also affects both free-roaming and captive Asian elephants in their natural range countries. To address this problem, our laboratory, in close partnership with the Houston Zoo, has developed a comprehensive “Bench to Barn” research program focusing on 1) diagnostics, 2) treatments, and long-term 3) a vaccine. Progress towards these goals has been made through the development of qPCR diagnostic assays, sequencing the EEHV genome, and developing tools to measure and evaluate elephant immune responses to EEHV. Trials evaluating a prototype vaccine against EEHV1A, the EEHV type associated with most disease in Asian elephants, have recently been initiated. Postdoctoral fellows and students who participate in this research develop skills applicable to research and vaccine development for any viral pathogen that infects humans or animals.

Websites

Selected Publications

• Cook, K.A., Ling, P.D., Terio, K.A., Baumgartner, W.A., Howard, L.L., and Landolfi, J.A. 2023. "." J Zoo Wildl Med. 2023;53:661-669. Pubmed PMID:
• Watts, J., Clinton, J.L.S., Pollet, J., Peng R.S., Tan, J., and P.D. Ling. "." Vaccines (Basel). 2024 Dec;12:1429. Pubmed PMID:
• Clinton, J.L.C., Hoornweg, T., Tan, J., Peng, RS., Schaftenaar, W., Rutten, V. P., de Haan, C.A.M., and PD Ling "." Vaccine. 2024 Aug;42:126227. Pubmed PMID:
• Clinton, J.L.C., Hoornweg, T., Tan, J., Peng, RS., Schaftenaar, W., Rutten, V. P., de Haan, C.A.M., and PD Ling "." Vaccine. 2022 Aug;40:5131-5140. Pubmed PMID:

Memberships

American Society for Virology

Member

American Society for Microbiology

Member

Elephant Endotheliotropic Herpesvirus (EEHV) Advisory Committee

Member