Positions
- Professor
-
Biochemistry and Molecular Biology
草榴社区入口
Houston, Texas United States
- Ruth McLean Bowman Bowers Professorship in Biochemistry
-
Biochemistry and Molecular Biology
草榴社区入口
Houston, Texas United States
- Member
-
Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Houston, Texas United States
Addresses
- 草榴社区入口 (Office)
-
BCM-Smith Medical Research Bldg
Room: BCMS-313
Houston, TX 77030
United States
Education
- Postdoctoral Fellowship at The Rockefeller University
- 08/2004 - NY, New York United States
- Mechanisms of the N-type inactivation gating and of ion permeation in potassium ion channels by X-ray crystallography and electrophysiology
- PhD from State University Of New York At Buffalo
- 07/1999 - Buffalo, New York United States
- Mechanism of ligand recognition and channel gating in acetylcholine receptor channels by single-channel recordings and kinetic analyses
Honors & Awards
- Pew Scholar in Biomedical Science
- 01/2006
- Alfred P. Sloan Fellow
- 01/2006
- Basil O鈥機onnor Starter Scholar Award
- 01/2006
- Irma Hirschl Award
- 01/2008
Professional Interests
- Membrane Transport Proteins and Membrane Embedded Enzymes
- Neuroscience
- Metabolism
- Enzymology
- Structural Biology
- Biomembranes
- Cancer Biology
- Chemical Biology
- Drug Discovery and Medicinal Chemistry
Professional Statement
Membrane transport proteins are transporters and channels that mediate the transmembrane flow of nutrients such as amino acids, sugars, nucleotides and ions. Membrane transport proteins are essential for maintaining cellular functions, and mutations in these proteins cause genetic diseases in humans. Dr. Zhou鈥檚 lab applies structural, functional and computational methods to understand basic chemical and physical principles in membrane transport proteins: How substrates are recognized; what structural changes are required for substrate translocation; and how the electrochemical gradient of one substrate drives the concentrative uptake of another substrate.Websites
Structure and Mechanism of Membrane Transport Proteins and Membrane Embedded Enzymes
Selected Publications
- Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, & Zhou M "." Nature. 2020 May 13;581(7808):329-332. Pubmed PMID:
- Zhang H, Pan Y, Hu L, Hudson MA, Hofstetter KS, Xu Z, Rong M, Wang Z, Prasad BVV, Lockless SW, Chiu W, Zhou M "." Nature Communications. 2020 Jan 28;11(1):547. Pubmed PMID:
- Ren Z, Lee J, Moosa MM, Nian Y, Hu L, Xu Z, McCoy JG, Ferreon ACM, Im W, Zhou M "." Proc Natl Acad Sci U S A.. 2018 May 21;115(23):5962-5967. Pubmed PMID:
- Bai Y, McCoy JG, Levin EJ, Sobrado P, Rajashankar KR, Fox BG, Zhou M "." Nature. 2015 Aug 13;524:252-256. Pubmed PMID:
- Huang H, Levin EJ, Liu S, Bai Y, Lockless SW, Zhou M "." PloS Biol. 2014 Jul 22;12(7):e1001911. Pubmed PMID:
- Zhou X, Levin EJ, Pan Y, McCoy JG, Sharma R, Kloss B, Bruni R, Quick M, Zhou M, "." Nature. 2014 Jan 23;505(7484):569-73. Pubmed PMID:
- Cao Y, Pan Y, Huang H, Jin X, Levin EJ, Kloss B, Zhou M. "." Nature. 2013 Apr 18;496(7445):317-22. Pubmed PMID:
- Pan Y, Levin EJ, Quick M, Zhou M. "." ACS Chem. Biol.. 2012 Oct 19;7(10):1641-6. Pubmed PMID:
- Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, Zhou M. "." Proc Natl Acad Sci USA. 2012 Jul 10;109(28):11194-11199. Pubmed PMID:
- Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson WA, Javitch JA, Rajashankar KR, Zhou M. "." Nature. 2011 May 5;473(7345):50-4. Pubmed PMID:
- Pan Y, Weng J, Levin EJ, Zhou M. "." Proc Natl Acad Sci. 2011 Apr 5;108(14):5885-90. Pubmed PMID:
- Cao Y, Jin X, Huang H, Derebe MG, Levin EJ, Kabaleeswaran V, Pan Y, Punta M, Love J, Weng J, Quick M, Ye S, Kloss B, Bruni R, Martinez-Hackert E, Hendrickson WA, Rost B, Javitch JA, Rajashankar KR, Jiang Y, Zhou M. "." Nature. 2011 Mar 17;471(7338):336-40. Pubmed PMID:
- Levin EJ, Quick M, Zhou M. "." Nature. 2009 Dec 10;462(7274):757-61. Pubmed PMID:
- Pan Y, Weng J, Cao Y, Bhosle RC, Zhou M. "." J. Biol. Chem.. 2008 Mar 28;283(13):8634-42. Pubmed PMID:
- Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle RC, Zhou M. "." Nat Chem Biol.. 2008 Nov;4(11):708-14. Pubmed PMID:
Memberships
- Biophysical Society
- member
- Protein Society
- member
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