Positions
- Associate Professor
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Pathology & Immunology
草榴社区入口
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Houston, Texas United States
Addresses
- Department of Pathology and Immunology (Office)
-
草榴社区入口
Houston, TX 77030
United States
- Department of Pathology and Immunology (Lab)
-
草榴社区入口
Houston, TX 77030
United States
Education
- BS from University of Science and Technology of China
- Hefei, China
- PhD from University of Southern California
- Los Angeles, California
- Postdoctoral Training at NIAMS, NIH
- Bethesda, Maryland
Professional Interests
- Autophagy and apoptosis in immune regulation
- Autoimmunity and inflammation
- Regulation of Memory B cell development and function
- Memory T cell development and function
- HIV cure
- Dendritic cells in immune regulation
Professional Statement
Molecular regulation of autoimmunity and inflammation.We have found that autophagy plays a critical role in the long-term survival of memory B cells against virus infection. In autoimmune and inflammatory diseases, the harmful T lymphocytes and B lymphocytes may activate autophagy and other mechanisms in order to persist in the disease process. We are investigating whether autophagy help to protect the long-term survival of autoimmune memory T cell and memory B cells for the development of autoimmune diseases, and whether autophagy deficiency suppress autoimmune and inflammatory responses.
Mitochondrial autophagy in the regulation of immune responses.
We have previously shown that a Bcl-2 family member, Nix, is critical for the regulation of mitochondrial autophagy during erythroid cell development. However, the mechanisms for Nix in mediated mitochondrial autophagy and its functions in immune responses remain to be elucidated. We identified Nix-interacting proteins by mass spectrometry analyses. We are using the CRISPR/Cas9-mediated gene targeting to delete genes encoding these proteins in cell lines and in mice. We will investigate the functions of these novel Nix-interacting proteins in the regulation of mitochondrial autophagy in immune memory cells.
Websites
Selected Publications
- Gupta SS, Sharp R, Hofferek C, Kuai L, Dorn GW 2nd, Wang J, Chen M. "." Cell Rep.. 2019 Nov 12;29(7):1862-1877. Pubmed PMID:
- Chen M, Hong MJ, Sun H, Wang L, Shi X, Gilbert BE, Corry DB, Kheradmand F, Wang J "." Nature Medicine. 2014 May;20:503-510. Pubmed PMID:
- Kodali, S., Li, M., Budai, M.M., Chen, M., and Wang, J. "." J. Immunol. 2022;208:1085- 1098. Pubmed PMID:
- Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J "." Nature. 2008 Jul 10;454:232-235. Pubmed PMID:
- Jang, A., Sharp, R., Wang, J.M., Feng, Y., Wang, J. and Chen, M. "." Front. Immunology. 2021 Jul 16; Pubmed PMID:
- Chen M, Kodali S, Jang A, Kuai L, Wang J "." J Immunol.. 2015 Mar 15;194:2607-2615. Pubmed PMID:
- Li M, Liu W, Bauch T, Graviss EA, Arduino RC, Kimata JT, Chen M, Wang J. "." Nat Commun.. 2020 Aug 13;11(1) Pubmed PMID:
- Chen, M. , Li, M., Budai, M.M., Rice, A.P., Kimata, J.T., Mohan, M., and Wang, J. "." J Leukoc Biol. 2022 Mar 31; Pubmed PMID:
- Gupta SS, Wang J, Chen M. "." Front Immunol.. 2020; Pubmed PMID:
- Chen M, Wang YH, Wang Y, Huang L, Sandoval H, Liu YJ, Wang J "." Science. 2006 Feb 24;311(5764):1160-4. Pubmed PMID:
- Zhang J, Kodali S, Chen M, Wang J. "." J Immunol.. 2020 Jul 1;205(1):113-120. Pubmed PMID:
- Chen M, Felix K, Wang J "." Blood. 2012 Jan 5;119(1):127-36. Pubmed PMID:
- Chen M, Huang L, Wang J "." Blood. 2007 May 15;109:4360-4367. Pubmed PMID:
- Chen M, Wang J "." Apoptosis. 2002 Aug;7:313-319. Pubmed PMID:
- Chen M, Guerrero AD, Huang L, Shabier Z, Pan M, Tan TH, Wang J. "." J Biol Chem.. 2007 Nov 16;282:33888-33895. Pubmed PMID:
Memberships
- The American Association of Immunologists
- American Heart Association
- The American Society of Hematology
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