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Email

Megumi.Mathison@bcm.edu

Positions

Associate Professor of Surgery

Division of Cardiothoracic Surgery
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Addresses

Alkek Building for Biomedical Research (Office)

Room: ABBR-411
Houston, TX 77030
United States

Education

Residency from University of Tokyo School of Medicine

., Tokyo Japan

Ph.D. from University of Tokyo

., Tokyo Japan

M.D. from Tokyo Medical and Dental University

., Tokyo Japan

Professional Interests

• In situ cardiac regeneration
• Cardiovascular disease
• Cardiac cellular reprogramming

Professional Statement

In 2010, it was reported that a combination of three transcription factors— Gata4, Mef2c, and Tbx5— reprogrammed postnatal murine cardiac fibroblasts directly into differentiated cardiomyocyte-like cells in vitro. Recently, several researchers, including our group, reported that resident cardiac fibroblasts were reprogrammed into cardiomyocyte-like cells in the murine heart by direct injection of Gata4, Mef2c, Tbx5 into the myocardium after coronary ligation. These results raise the possibility that we can generate new cardiomyocytes from scar tissue after myocardial infarction in humans.

Websites

Selected Publications

• Mathison M, P Gersch R, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Shroyer K, Yang J, Ma Y, Crystal RG, Rosengart TK "In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor.." J Am Heart Assoc. 2012;1(6)
• Cui J, Li J, Mathison M, Tondato F, Mulkey SP, Micko C, Chronos NA, Robinson KA "A clinically relevant large-animal model for evaluation of tissue-engineered cardiac surgical patch materials.." Cardiovasc Revasc Med. 2005;6(3):113-120.
• Robinson KA, Li J, Mathison M, Redkar A, Cui J, Chronos NA, Matheny RG, Badylak SF "Extracellular matrix scaffold for cardiac repair.." Circulation. 2005;112
• Mathison MN, Becker GJ, Katzen BT, Benenati JF, Zemel G, Powell A, Lima MM "Implications of problematic access in transluminal endografting of abdominal aortic aneurysm.." J Vasc Interv Radiol. 2003;14(1)