Positions
- Associate Professor
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Pediatrics-Nutrition
草榴社区入口
Houston, TX US
- Associate Professor
-
Molecular Physiology & Biophysics
草榴社区入口
Houston, Texas United States
- Director
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Mouse Metabolic Research Unit
Children's Nutrition Research Center
草榴社区入口
Houston, Texas United States
Education
- Postdoctoral Fellowship at Baylor College Of Medicine
- 01/1982 - Houston, TX United States
- Pediatric Nutrition & GI
- PhD from University of Cambridge
- 01/1980 - Cambridge, United Kingdom
- BSc from University of Manchester Institute of Science and Technology
- 01/1976 - Manchester, United Kingdom
Professional Interests
- Developmental Determinants of Skeletal Muscle Growth
Professional Statement
The major objective of our research is to identify the mechanisms that underlie the various effects of nutrient intake on the growth and function of skeletal muscle. In the perinatal period, skeletal muscle is the fastest growing protein pool in the body and, thus, is highly dependent on nutrient supply and the ability to use dietary nutrients efficiently. Thus, one of our research interests is to understand how nutrients regulate the primary anabolic processes responsible for muscle growth, i.e., protein synthesis and satellite cell replication during this period.A second research interest is rooted in the observation that a brief period of growth retardation during a critical period of development results in a lifelong deficit in muscle mass and exercise capacity. We are conducting research to understand why this happens and to identify interventions that can reverse the muscle deficit and improve exercise performance.
We perform studies using the mouse and the newborn piglet as animal models, together with a wide array of techniques including in vivo tracer kinetics, in vivo metabolic measurements, an assortment of molecular biology techniques, microscopy, cell culture, and muscle physiology measurements to address these research questions.
Websites
Selected Publications
- Klurfeld DM, Gregory JF, Fiorotto ML "." J Nutr.. 2021 Mar 10; Pubmed PMID:
- Rudar M, Naberhuis JK, Suryawan A, Nguyen HV, Stoll B, Style CC, Verla MA, Olutoye OO, Burrin DG, Fiorotto ML, Davis TA. "." Am J Physiol Endocrinol Metab.. 2021 Mar 1;320(3):E551-E565. Pubmed PMID:
- Rudar M, Columbus DA, Steinhoff-Wagner J, Suryawan A, Nguyen HV, Fleischmann R, Davis TA, Fiorotto ML. "." J Nutr.. 2020 Jan 1;150(1):22-30. Pubmed PMID:
- Ferguson DP, Monroe TO, Heredia CP, Fleischmann R, Rodney GG, Taffet GE, Fiorotto ML. "." J Physiol.. 2019 Apr;597(7):1855-1872. Pubmed PMID:
Languages
Italian, French, Swahili
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