Lisa Bouchier-Hayes, Ph.D.
Picture
Positions
- Assistant Professor
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Pediatrics
Hem-Onc Cell & Gene Therapy
草榴社区入口
Houston, TX US
- Assistant Professor
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Molecular and Cellular Biology
草榴社区入口
Houston, Texas United States
Addresses
- Texas Children's Hospital (Office)
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1102 Bates Ave
Feigin Tower Suite 1030.08
Houston, TX 77030
United States
bouchier@bcm.edu
Education
- BA from Trinity College Dublin
- 06/1998 - Dublin, Ireland
- PhD from Trinity College Dublin
- 06/2002 - Dublin, Ireland
- Postdoctoral Fellowship at LaJolla Institute of Allergy and Immunology
- 01/2006 - San Diego, California United States
- Molecular mechanisms of apoptosis
- Postdoctoral Fellowship at St Jude Children's Research Hospital
- 01/2011 - Memphis, Tennessee United States
- Molecular mechanisms of apoptosis
Professional Statement
The focus of my lab is to determine how members of the caspase family of proteases function in apoptosis and non-apoptotic processes to protect from disease. Specifically, we develop and use cutting edge live cell imaging-based methodologies to interrogate activation of distinct caspases in normal and transformed cells. Our research program is currently focused on two major areas: (1) caspase regulation in cancer; and (2) caspase activation during inflammation. The rationale for these investigations is that caspases protect from cancer and other diseases, by engaging diverse cellular mechanisms in addition to cell death, such as cell division, inflammation, and DNA repair. The ultimate goal is to understand how these caspase pathways can be manipulated for preventative and therapeutic purposes.Websites
Selected Publications
- Beatriz E Bol铆var, Alexandra N Brown-Suedel, Brittany A Rohrman, Chlo茅 I Charendoff, Vanda Yazdani, John D Belcher , Gregory M Vercellotti , Jonathan M Flanagan, Lisa Bouchier-Hayes "." J Immunol .. 2021 Apr 15;206(8):1878-1889. Pubmed PMID:
- Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S, Bouchier-Hayes L. "." J Cell Biol.. 2017;216:1795-1810. Pubmed PMID:
- Sanders MG, Parsons MJ, Howard AG, Liu J, Fassio SR, Martinez JA, Bouchier-Hayes L "." Cell Death Dis. 2015 Jul 9;6:e1813. Pubmed PMID:
- Ando M, Hoyos V, Yagyu S, Tao W, Ramos CA, Dotti G, Brenner MK, Bouchier-Hayes L. "." Cancer Gene Ther. 2014 Nov;21(11):472-82. Pubmed PMID:
- Parsons MJ, McCormick L, Janke L, Howard A, Bouchier-Hayes L, Green DR "." Cell Death Differ.. 2013 Sep;20(9):1174-82. Pubmed PMID:
- Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DR "." Mol. Cell. 2009 Sep 24;35(6):830-40. Pubmed PMID:
- Bouchier-Hayes L, McBride S, van Geelen CM, Nance S, Lewis LK, Pinkoski MJ, Beere HM "." Cell Death Differ.. 2010 Jun;17(6):1034-46. Pubmed PMID:
- Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ "." J. Biol. Chem.. 2001 Nov 23;276(47):44069-77. Pubmed PMID:
- Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. "." Oncogene. 2016 Dec 19; Pubmed PMID:
- Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra J "." Sci Rep. 2016 Jan 25;6:18953. Pubmed PMID:
- Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SW. "." Mol Cell.. 2015 Mar 5;57(5):860-72. Pubmed PMID:
- Ando K, Kernan JL, Liu PH, Sanda T, Logette E, Tschopp J, Look AT, Wang J, Bouchier-Hayes L, Sidi S "." Mol. Cell. 2012 Sep 14;47(5):681-93. Pubmed PMID:
- Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR "." Mol. Cell. 2011 Nov 18;44(4):517-31. Pubmed PMID:
- Tait SW, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, Mu帽oz-Pinedo C, Green DR "." Dev. Cell. 2010 May 18;18(5):802-13. Pubmed PMID:
- Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR "." Cell. 2007 Jun 1;129(5):983-97. Pubmed PMID:
- Bonzon C, Bouchier-Hayes L, Pagliari LJ, Green DR, Newmeyer DD "." Mol. Biol. Cell. 2006 May;17(5):2150-7. Pubmed PMID:
- Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR "." Science. 2005 Sep 9;309(5741):1732-5. Pubmed PMID:
- Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD "." Mol. Cell. 2005 Feb 18;17(4):525-35. Pubmed PMID:
- Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR "." Science. 2004 Feb 13;303(5660):1010-4. Pubmed PMID:
- Hoyos V, Del Bufalo F, Yagyu S, Ando M, Dotti G, Suzuki M, Bouchier-Hayes L, Alemany R, Brenner MK. "." Mol Ther.. 2015 Sep;23(9):1497-506. Pubmed PMID:
- Nishio N, Diaconu I, Liu H, Cerullo V, Caruana I, Hoyos V, Bouchier-Hayes L, Savoldo B, Dotti G "." Cancer Res. 2014 Sep 15;74(18):5195-205. Pubmed PMID:
- Collingridge DR, Glaser M, Osman S, Barthel H, Hutchinson OC, Luthra SK, Brady F, Bouchier-Hayes L, Martin SJ, Workman P, Price P, Aboagye EO "." Br. J. Cancer. 2003 Oct 6;89(7):1327-33. Pubmed PMID:
- Glaser M, Collingridge DR, Aboagye EO, Bouchier-Hayes L, Hutchinson OC, Martin SJ, Price P, Brady F, Luthra SK "." Appl Radiat Isot. 2003 Jan;58(1):55-62. Pubmed PMID:
- Keogh SA, Walczak H, Bouchier-Hayes L, Martin SJ "." FEBS Lett.. 2000 Apr 7;471(1):93-8. Pubmed PMID:
- Mynett-Johnson L, Kealey C, Claffey E, Curtis D, Bouchier-Hayes L, Powell C, McKeon P "." Am. J. Med. Genet.. 2000 Dec 4;96(6):845-9. Pubmed PMID:
- Bouchier-Hayes L, Green DR "." Cell Death Differ.. 2012 Jan;19(1):51-7. Pubmed PMID:
- Bouchier-Hayes L, Sidi S. "." Cell Cycle. 2017;16:1562-3. Pubmed PMID:
- Bouchier-Hayes L "." J. Cell. Mol. Med.. 2010 Jun;14(6):1212-24. Pubmed PMID:
- Bouchier-Hayes L, Green DR "." Cell Cycle. 2010 Jan 1;9(1):41611. Pubmed PMID:
- Chipuk JE, Bouchier-Hayes L, Green DR "." Cell Death Differ.. 2006 Aug;13(8):1396-402. Pubmed PMID:
- Bouchier-Hayes L, Lartigue L, Newmeyer DD "." J. Clin. Invest.. 2005 Oct;115(10):2640-7. Pubmed PMID:
- Bouchier-Hayes L, Martin SJ "." Vitam. Horm.. 2004;67:133-47. Pubmed PMID:
- Bouchier-Hayes L, Martin SJ "." EMBO Rep.. 2002 Jul;3(7):616-21. Pubmed PMID:
- Parsons MJ, Fassio SR, Bouchier-Hayes L. "." Methods Mol Biol.. 2016;1419:41-56. Pubmed PMID:
- Parsons MJ, Rehm M, Bouchier-Hayes L. "." Cold Spring Harb Protoc.. 2015 Jan;5 Pubmed PMID:
- Rehm M, Parsons MJ, Bouchier-Hayes L. "." Cold Spring Harb Protoc.. 2015 Jan;5 Pubmed PMID:
- Parsons MJ, Bouchier-Hayes L. "." Cold Spring Harb Protoc.. 2015 Jan;5 Pubmed PMID:
- Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DR "." Methods Mol. Biol.. 2009;559:33-48. Pubmed PMID:
- Bouchier-Hayes L, Mu帽oz-Pinedo C, Connell S, Green DR "." Methods. 2008 Mar;44(3):222-8. Pubmed PMID:
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