Positions
- Professor
-
Department of Neuroscience
草榴社区入口
Houston, TX US
- Professor
-
Department of Biochemistry and Molecular Pharmacology
草榴社区入口
Houston, TX US
Education
- PhD from Harvard Medical School
- 05/1998 - Boston, MA US
- Cell Biology - Signal Transduction
- Post-Doctoral Fellowship at Harvard Medical School
- 09/2006 - Boston, MA US
- Neuroscience
- Post-Doctoral Fellowship at Harvard Medical School
- 09/1999 - Boston, MA US
- Cell Biology - Signal Transduction
- BS from University of Minnesota
- 05/1992 - Minneapolis, MN US
- Biochemistry
Professional Interests
- Molecular and cellular mechanisms regulating mammalian neural circuit development and plasticity in health and disease/injury
- Formation and activity-dependent remodeling of excitatory and inhibitory synapses
- Axonal and dendritic growth
- Directed cell migration
- Rho GTPase and Adhesion-GPCR signaling in the nervous system
Professional Statement
The long-term goal of our research is to understand the molecular and cellular mechanisms underlying neural circuit formation and plasticity in the mammalian central nervous system (CNS) in the context of both health and disease/injury. A major focus of our research is elucidating how neurons sense external cues and transduce intracellular signals that direct essential processes like synapse development and remodeling, dendritic/axonal growth, and cell migration. In addition to investigating how these processes are normally regulated, we examine how dysregulation of key signaling pathways (particularly those regulating cytoskeletal dynamics) contribute to neurological disorders (e.g., intellectual disabilities, autism spectrum disorder, Alzheimer鈥檚 disease, depression, anxiety, and chronic pain) and whether targeting these pathways can promote recovery following injury or disease. Our laboratory is also actively engaged in numerous collaborative projects, including examining the synaptic mechanisms underlying cognitive decline following radiation therapy and the effects of the gut microbiome on brain development and behavior. To accomplish these goals, we utilize a multidisciplinary approach, employing in vivo and in vitro rodent models and a combination of state-of-the-art genetic, molecular, cellular, biochemical, electrophysiological, and behavioral methods.Websites
Selected Publications
- Li L, Ru Q, Lu Y, Fang X, Chen G, Saifullah AB, Yao C, Tolias KF. "." Neuron. 2023 Jul 5;111(13):2038-2050. Pubmed PMID:
- Ru Q, Lu Y, Saifullah AB, Blanco FA, Yao C, Cata JP, Li DP, Tolias KF, Li L. "." J Clin Invest.. 2022 Dec 15;132(24):e158545.. Pubmed PMID:
- Cheng J, Scala F, Blanco FA, Niu S, Firozi K, Keehan L, Mulherkar S, Froudarakis E, Li L, Duman JG, Jiang X, Tolias KF. "." J Neurosci.. 2021 Feb 10;41(6):1191-1206. Pubmed PMID:
- Duman JG, Mulherkar S, Tu YK, Erikson KC, Tzeng CP, Mavratsas VC, Ho TS, Tolias KF. "." Elife. 2019 Aug 28;8:e47566. Pubmed PMID:
- Tu YK, Duman JG, Tolias KF. "." J Neurosci.. 2018 Sep 26;38(39):8388-8406. Pubmed PMID:
- Yao C, Fang X, Ru Q, Li W, Li J, Mehsein Z, Tolias KF, Li L. "." Brain. 2024 Apr 5;(awae106) Pubmed PMID:
- Sharma J, Mulherkar S, Chen UI, Xiong Y, Bajaj L, Cho BK, Goo YA, Leung HE, Tolias KF, Sardiello M "." Cell Discov.. 2023 Mar 24;9(1):32. Pubmed PMID:
- Duman JG, Blanco FA, Cronkite CA, Ru Q, Erikson KC, Mulherkar S, Saifullah AB, Firozi K, Tolias KF. "." Small GTPases. 2022 Jan 13;1:14-47. Pubmed PMID:
- Choudhury D, Autry AE, Tolias KF, Krishnan V. "." Front Neurosci.. 2021 Sep 10;15:672526. Pubmed PMID:
- Cadwell CR, Scala F, Fahey PG, Kobak D, Mulherkar S, Sinz FH, Papadopoulos S, Tan ZH, Johnsson P, Hartmanis L, Li S, Cotton RJ, Tolias KF, Sandberg R, Berens P, Jiang X, Tolias AS. "." Elife. 2020 Mar 5;9:e52951. Pubmed PMID:
- Wang L, Pang K, Han K, Adamski CJ, Wang W, He L, Lai JK, Bondar VV, Duman JG, Richman R, Tolias KF, Barth P, Palzkill T, Liu Z, Holder JL Jr, Zoghbi HY. "." Mol Psychiatry. 2020 Oct;25(10):2534-2555. Pubmed PMID:
- Mulherkar S, Tolias KF. "." Cells. 2020 Jan 18;9(1):245. Pubmed PMID:
- Morgan, Anderson, Ara莽, Aust, Balenga, Boucard, Bridges, Engel, Formstone, Glitsch, Gray,Hall,Hsiao,Kim,Knierim,Kusuluri,Leon, Liebscher, Piao, Pr枚mel, Scholz, Srivastava, Thor, Tolias, Ushkaryov,Vallon, Van Meir ,Vanhollebeke,Wolfrum,Wright, Monk, Mogha. "." Ann N Y Acad Sci.. 2019 Nov;1456(1):5-25. Pubmed PMID:
- Duman JG, Dinh J, Zhou W, Cham H, Mavratsas VC, Pave拧kovic M, Mulherkar S, McGovern SL, Tolias KF, Grosshans DR. "." Neuro Oncol.. 2018 Apr 9;20(5):655-665. Pubmed PMID:
- Mulherkar S, Firozi K, Huang W, Uddin MD, Grill RJ, Costa-Mattioli M, Robertson C, Tolias KF. "." Sci Rep.. 2017 Sep 6;7(1):10689. Pubmed PMID:
- Duman JG, Tu YK, Tolias KF. "." Neural Plast.. 2016;8301737 Pubmed PMID:
- Duman JG, Tolias KF. "." Dev Cell.. 2016 Oct 24;39(2):136-138. Pubmed PMID:
- Lai KO, Jordan BA, Ma XM, Srivastava DP, Tolias KF. "." Neural Plast.. 2016;2078121 Pubmed PMID:
- Cadwell, C.R., Palasantza, A., Jiang, X., Berens, P., Deng, Q., Yilmaz, M., Reimer, J., Shen, S., Bethge, M., Tolias, K. F., Sandberg, R., Tolias, A.S. "Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq." Nat Biotechnol.. 2015 Dec 21;
- Duman, JG, Mulherkar, S., Tu, YK., Cheng, J., Tolias, K.F. "." Neurosci Lett.. 2015 Aug 5;601:4-10. Pubmed PMID:
- Um, K., Niu, S., Duman, J. G., Cheng, J., Tu, Y-K., Schwechter, B., Liu, F., Hiles, L., Narayanan, A., Ash, R. T. Mulherkar, S., Alpadi, K., Smirnakis, S. M., Tolias, K. F. "." Dev Cell. 2014;29(6):701-715. Pubmed PMID:
- Mulherkar, S., Uddin, M.D., Couvillon, A., Sillitoe, R., Tolias, K. F. "." Dev. Biol.. 2014 Aug 14;Epub ahead of p. Pubmed PMID:
- Schwechter, B., Rosenmund, C., Tolias, K. F. "." Proc. Natl. Acad. Sci. USA. 2013 Aug 27;110(35):14462-14467. Pubmed PMID:
- Mulherkar, M., Liu, F., Chen, Q., Narayanan, A. S., Couvillon, A., Shine, H. D., Tolias, K. F. "." PLoS One. 2013 Jun 25;8(6):e67015. Pubmed PMID:
- Narayanan, A. S., Reyes, S. B., Um, K., McCarty, J. H., Tolias, K. F. "." Mol Biol Cell.. 2013 Dec;24(24):3857-3868. Pubmed PMID:
- Duman, J. G., Tzeng, C. P., Tu, Y-K., Munjal, T., Schwechter, B., Ho, T., Tolias, K. F. "." J Neurosci.. 2013 Apr 17;33(16):6964-6978. Pubmed PMID:
- Schwechter, B. and Tolias, K. F. "." Commun Integr Biol.. 2013 Nov 1;6(6):e27343. Pubmed PMID:
- Reyes, S. B., Narayanan, A. S., Lee, H.S., Tchaicha, J. H., Aldape, K.D., Lang, F. F., Tolias, K. F., McCarty, J. H. "." Mol. Biol. Cell.. 2013 Feb;24(4):472-482. Pubmed PMID:
- Tolias KF, Duman JG, Um K "." Prog. Neurobiol.. 2011 Jul;94(2):133-48. Pubmed PMID:
- Tolias, K. F., Bikoff, J. B., Kane, C. G., Tolias, C. S., Hu, L., Greenberg, M. E. "." Proc. Natl. Acad. Sci. USA. 2007 Apr 24;104(17):7265-7270. Pubmed PMID:
- Zhou, P., Porcionatto, M., Pilapil, M., Chen, Y., Choi, Y., Tolias, K. F., Bikoff, J. B., Hong, E.J., Greenberg, M. E., Segal, R. A. "." Neuron. 2007 Jul 5;55(1):53-68. Pubmed PMID:
- Tolias, K. F.*, Bikoff, J.B.*, Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R.J., Greenberg, M. E. "." Neuron. 2005 Feb 17;45(4):525-538. Pubmed PMID:
- Saito, K.*, Tolias, K. F.*, Saci, A., Koon H.B., Humphries, L.A., Scharenberg, A., Rawlings, D.J., Kinet, J-P and Carpenter, C. L. "." Immunity. 2003 Nov;19(5):669-78. Pubmed PMID:
- Tolias, K. F., Hartwig, J. H., Ishihara, H., Shibasaki, Y., Cantley, L. C., Carpenter, C. L. "." Curr. Biol.. 2000;10(3):153-156. Pubmed PMID:
- Tolias, K. F. and Carpenter, C. L. "." Methods Enzymol.. 2000;325:190-200. Pubmed PMID:
- Kost, B., Lemichez, E., Spielhofer, P., Hong, Y., Tolias, K. F., Carpenter, C. L., Chua, N-H. "." J. Cell Biol.. 1999;145:317-330. Pubmed PMID:
- Tolias, K. F. and Cantley, L. C. "." Chem. Phys. Lipids. 1999;98:69-77. Pubmed PMID:
- Carpenter CL, Tolias KF, Van Vugt A, Hartwig J. "." Adv Enzyme Regul.. 1999;39:299-312. Pubmed PMID:
- Tolias, K. F., Rameh, L. E., Ishihara, H., Shibasaki, Y., Chen, J., Prestwich, G. D., Cantley, L. C., Carpenter, C. L. "." J. Biol. Chem.. 1998;273:18040-18046. Pubmed PMID:
- Tolias, K. F., Couvillon, A. D., Cantley, L. C., Carpenter, C. L. "." Mol. Cell Biol.. 1998;18:762-770. Pubmed PMID:
- Rameh, L. E., Tolias, K. T., Duckworth, B., Cantley, L. C. "." Nature. 1997;390:192-196. Pubmed PMID:
- Berditchevski, F, Tolias, K. F., Wong, K, Carpenter, C. L., Hemler, M. E. "." J. Biol. Chem.. 1997 Jan 31;272(5):2595-258. Pubmed PMID:
- Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH. "." Adv Enzyme Regul.. 1997;37:377-90. Pubmed PMID:
- Kolluri, R., Tolias, K. F., Carpenter, C. L., Rosen, F. S., Kirchhausen, T. "." Proc Natl Acad Sci U S A.. 1996;93(11):5615-8. Pubmed PMID:
- Tolias, K. F., Cantley, L. C., and Carpenter, C. L. "." J Biol Chem.. 1995;270(30):17656-9. Pubmed PMID:
- Fuchs KR*, Shekels LL, Bernlohr DA. "." Biochem Biophys Res Commun. 1992 Dec 30;189(3):1598-605. Pubmed PMID:
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