Jonathan Marcus Fogg, Ph.D.
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Positions
- Senior Staff Scientist
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Virol & Micro: Zechiedrich
草榴社区入口
Houston, TX US
Education
- Postdoctoral Training at 草榴社区入口
- 11/2011 - Houston, Texas United States
- Postdoctoral Training at University of California at Santa Barbara
- 06/2005 - Santa Barbara, California United States
- BS from University of Leeds
- 07/1996 - Leeds, United Kingdom
- PhD from University of Dundee
- 07/2001 - Dundee, United Kingdom
Professional Statement
Throughout my research I have focused on how DNA is able to be an active participant in its transactions. DNA structure, particularly the structure of supercoiled DNA, is much more variable and dynamic than many people realize. This insight has allowed me to contribute to a better understanding of protein-DNA interactions and DNA itself. In the process, I have also developed unique DNA tools that are proving to be extremely useful, not only for basic research, but also clinical applications. I have developed a patented protocol to generate milligram quantities of supercoiled minicircle DNA, as small as 250 bp. Using these DNA minicircles, I precisely determine the supercoiling dependence of topoisomerase binding and additionally elucidate the mechanism through which DNA topoisomerases recognize their supercoiled DNA substrate and determine where to act. These minicircles also provide a unique insight into the structure of supercoiled DNA, including previously unappreciated differences between overwound and underwound DNA. Throughout my career I have collaborated with researchers from many disciplines including biochemistry, biophysics, physics, mathematics, structural biology, and medicine.Selected Publications
- Wang, Q.; Irobalieva R.N.; Chiu W., Schmid M.F.; Fogg J.M.; Zechiedrich L.; Pettitt B.M. "." Nucleic Acids Res.. 2017 Jul 27;45(13):7633-7642. Pubmed PMID:
- Fogg J.M.; Catanese D.J. Jr.; Randall G.L.; Swick M.C.; Zechiedrich L. "." Mathematics of DNA Structure, Function and Interactions. 2009;150:73-121.
- Fogg, J.M.; Randall, G.L.;Pettitt, B.M.;Sumners, D.W.; Harris, S.A.; and Zechiedrich, L.. "." Quarterly Review of Biophysics. 2012;45:257-299.
- Fogg J.M.; Kvaratskhelia, M.; White M.F.; Lilley D.M.J. "." J. Mol. Biol.. 2001 Nov 3;313(4):751-764. Pubmed PMID:
- Fogg D.M.J.; Lilley D.M.J. "." Biochemistry. 2000 Dec 26;39(51):16125-16134. Pubmed PMID:
- Fogg J.M.; Kolmakova N.; Rees I.; Magonov S.; Hansma H.; Perona J.J.; Zechiedrich E.L. "." J Phys Condens Matter. 2006 Mar 24;18(14):S145-S159. Pubmed PMID:
- Kvaratskhelia M.; Wardleworth B.N.; Bond C.S.; Fogg J.M.; Lilley D.M.J.; White M.F. "." 2002 Jan 25;277(4):2992-2996. Pubmed PMID:
- Fogg J.M.; Schofield M.J.; White M.F.; Lilley D.M.J. "." Biochemistry. 1999 Aug 31;38(35):11349-11358. Pubmed PMID:
- Hiller D.A.; Fogg J.M.; Martin A.M.; Beechem J.M.; Reich N.O.; Perona J.J. "." Biochemistry. 2003 Dec 16;42(49):14375-14385. Pubmed PMID:
- Irobalieva, R.N.; Fogg J.M.; Catanese D.J. Jr.; Sutthibutpong, T.; Chen M.; Barker A.K.; Ludtke S.J.; Harris S.A.; Schmid M.F.; Chiu W.; Zechiedrich L. "." Nat Commun.. 2015 Oct 12;6:8440. Pubmed PMID:
- Catanese D.J. Jr.; Fogg J.M.; Schrock D.E. 2nd.; Gilbert B.E.; Zechiedrich L. "." Gene Ther.. 2012 Jan;19(1):94-100. Pubmed PMID:
- D茅clais A.C.; Fogg J.M.; Freeman A.D.; Coste F.; Hadden J.M.; Phillips S.E.; Lilley D.M.J. "." EMBO J.. 2003 Mar 17;22(6):1398-1409. Pubmed PMID:
- Bizard, A.H.; Yang, X.; D茅bat, H.; Fogg, J.M.; Strick, T.R.; Garnier, F.; Nadal, M. "." Nucleic Acids Res.. 2018 Jan 25;46(2):861-872. Pubmed PMID:
- Zhao, N.; Fogg, J.M.; Zechiedrich L.; Yu Z. "." Gene Ther.. 2011;18(3):220-224. Pubmed PMID:
- Fogg J.M.; Schofield M.J.; D茅clais A.C.; Lilley D.M.J. "." Biochemistry. 2000 Apr 11;39(14):4082-4089. Pubmed PMID:
- Fogg, J.M., Judge, A.K., Stricker, E., Chan, H.L., Zechiedrich, L. "." Nat. Commun.. 2021 Sep;12(1):5683. Pubmed PMID:
- Waszkiewicz, R., Ranasinghe, M., Fogg, J.M., Catanese, D.J., Ekiel-Je偶ewska, M.L., Lisicki, M., Demeler, B., Zechiedrich, L. Szymczak, P. "." Nucleic Acids Res.. 2023 May;51(8):4027-4042. Pubmed PMID:
- Ranasinghe, M., Fogg, J.M., Catanese Jr., D.J., Zechiedirch, L., Demeler, B. "." Eur Biophys J.. 2023 Jul;52:267-280. Pubmed PMID:
- Ar茅valo-Soliz, L.M., Hardee, C.L., Fogg, J.M., Corman, N.R., Noorbakhsh, C., Zechiedrich, L. "." Cell Gene Ther Insights. 2020 Nov;6(10):1489-1505. Pubmed PMID:
- Zechiedrich, L., Fogg, J.M. "." Technol Innov .. 2019 Aug;20(4):427-439. Pubmed PMID:
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