Jianming Xu, Ph.D.
Picture
Positions
- Gordon Cain Endowed Professorship in Cell Biology
-
Mol & Cell Biology-Xu
草榴社区入口
Houston, TX US
Addresses
- Gordon Cain Endowed Professorship in Cell Biology, Department of Molecular and Cellular Biology; Director of the Genetically Engineered Mouse Core, 草榴社区入口 (Office)
-
One Baylor Plaza, Alkek Building, Room N630.03
Houston, TX 77030
United States
Education
- PhD from Clarkson University/W. Alton Johns Cell Science Center
- 05/1994 - Potsdam, NY United States
- Postdoctoral Training at Baylor College Of Medicine
- 10/1997 - Houston, TX United States
Professional Interests
- Gene networks & signaling pathways that regulate steroid hormone-promoted cancers
Professional Statement
Overexposure and/or super sensitiveness to sex steroid hormones, such as estrogen and androgen, are risk factors that promote breast, endometrial and prostate carcinogenesis. Because of the high incidences and mortality, these steroid-promoted cancers remain to be a major threat to human health. Steroid receptors are transcription factors that depend on their coregulators to regulate specific gene expression. Each receptor can work with multiple coregulators and each coregulators also can work with multiple receptors and other types of transcription factors to regulate gene expression. In turn, these gene products are involved in various signaling pathways that control initiation, progression and metastasis of these steroid promoted cancers. Our research is mainly focused on determining the oncogenic or tumor-suppressive roles of a group of coregulators altered in breast, prostate or endometrial cancers and elucidating their molecular mechanisms for regulating the initiation, progression and metastasis of these cancers. Our ultimate goal is to identify cancer type-specific targets and pathways for the cure of steroid-promoted cancers.Our lab is adequately equipped to execute multidisciplinary, complex studies from a single molecule to an entire mouse. In addition to common molecular, cellular and animal approaches, we routinely use many advanced technologies in our research, such as gene expression profiling, ChIP-Seq, whole genome sequencing, metabolomic profiling, Co-IP/mass spectrometry, gene knock-down/knockout/knock-in in various cell lines or mice, generation and staining of micro tissue arrays, and various kinds of xenograft/transgenic mouse models of human cancers. We have many years of experience on generating and characterization of genetically engineered mouse models.
Up to date, Dr. Xu has published ~160 peer-reviewed articles and trained 32 postdocs and 11 graduate students.
Websites
Selected Publications
- Xu J, Liao L, Ning G, Yoshida-Komiya H, Deng C, O'Malley BW "." Proc. Natl. Acad. Sci. U.S.A.. 2000 Jun 6;97(12):6379-84. Pubmed PMID:
- Qin L, Liu Z, Chen H, Xu J "." Cancer Res.. 2009 May 1;69(9):3819-27. Pubmed PMID:
- Fu J, Qin L, He T, Qin J, Hong J, Wong J, Liao L, Xu J "." Cell Res.. 2011 Feb;21(2):275-89. Pubmed PMID:
- Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H, O'Malley BW, Xu J "." Mol. Cell. Biol.. 2008 Oct;28(19):5937-50. Pubmed PMID:
- Qin L, Chen X, Wu Y, Feng Z, He T, Wang L, Liao L, Xu J "." Cancer Res.. 2011 Mar 1;71(5):1742-51. Pubmed PMID:
- Hong J, Zhou J, Fu J, He T, Qin J, Wang L, Liao L, Xu J "." Cancer Res.. 2011 Jun 1;71(11):3980-90. Pubmed PMID:
- Mark M, Yoshida-Komiya H, Gehin M, Liao L, Tsai MJ, O'Malley BW, Chambon P, Xu J "." Proc. Natl. Acad. Sci. U.S.A.. 2004 Mar 30;101(13):4453-8. Pubmed PMID:
- Xu J, Qiu Y, DeMayo FJ, Tsai SY, Tsai MJ, O'Malley BW "." Science. 1998 Mar 20;279(5358):1922-5. Pubmed PMID:
- Qin Q, Xu Y, He T, Qin C, Xu J "." Cell Res.. 2012 Jan;22(1):90-106. Pubmed PMID:
- Xu J, Wu RC, O'Malley BW "." Nat. Rev. Cancer. 2009 Sep;9(9):615-30. Pubmed PMID:
- Kuang SQ, Liao L, Wang S, Medina D, O'Malley BW, Xu J "." Cancer Res.. 2005 Sep 1;65(17):7993-8002. Pubmed PMID:
- Liu Z, Zhou S, Liao L, Chen X, Meistrich M, Xu J "." J. Biol. Chem.. 2010 Jan 22;285(4):2758-70. Pubmed PMID:
- Zhang H, Kuang SQ, Liao L, Zhou S, Xu J "." Cancer Res.. 2004 Oct 1;64(19):7169-77. Pubmed PMID:
- Yuan Y, Qin L, Liu D, Wu RC, Mussi P, Zhou S, Songyang Z, Xu J "." Cancer Res.. 2007 Sep 1;67(17):8032-42. Pubmed PMID:
- Chung AC, Zhou S, Liao L, Tien JC, Greenberg NM, Xu J "." Cancer Res.. 2007 Jun 15;67(12):5965-75. Pubmed PMID:
- Wang S, Yuan Y, Liao L, Kuang SQ, Tien JC, O'Malley BW, Xu J "." Proc. Natl. Acad. Sci. U.S.A.. 2009 Jan 6;106(1):151-6. Pubmed PMID:
- Kuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, Ko L, Xu J "." J. Biol. Chem.. 2002 Nov 22;277(47):45356-60. Pubmed PMID:
- Kuang SQ, Liao L, Zhang H, Lee AV, O'Malley BW, Xu J "." Cancer Res.. 2004 Mar 1;64(5):1875-85. Pubmed PMID:
- Chen X, Liu Z, Xu J "." Mol. Endocrinol.. 2010 Oct;24(10):1917-34. Pubmed PMID:
- Yuan Y, Liao L, Tulis DA, Xu J "." Circulation. 2002 Jun 4;105(22):2653-9. Pubmed PMID:
- Li Q, Chu MJ, Xu J "." Mol. Cell. Biol.. 2007 Dec;27(23):8073-86. Pubmed PMID:
- Xu J, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW "." Proc. Natl. Acad. Sci. U.S.A.. 1996 Oct 29;93(22):12195-9. Pubmed PMID:
- Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW "." Cell Metab.. 2010 Dec 1;12(6):606-18. Pubmed PMID:
- Liao L, Dearth RK, Zhou S, Britton OL, Lee AV, Xu J "." Endocrinology. 2006 Aug;147(8):3877-88. Pubmed PMID:
- Weiss RE#, Xu J#, Ning G, Pohlenz J, O鈥橫alley BW, and Refetoff S "Mice deficient in the steroid receptor coactivator-1 (SRC-1) are resistant to thyroid hormone." EMBO J. 1999;18:1900-4.
- Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM "." Science. 1999 Nov 12;286(5443):1368-71. Pubmed PMID:
- Nishihara E, Yoshida-Komiya H, Chan CS, Liao L, Davis RL, O'Malley BW, Xu J "." J. Neurosci.. 2003 Jan 1;23(1):213-22. Pubmed PMID:
- Zhang H, Liao L, Kuang SQ, Xu J "." Endocrinology. 2003 Apr;144(4):1435-43. Pubmed PMID:
- Xu J, Li Q "." Mol. Endocrinol.. 2003 Sep;17(9):1681-92. Pubmed PMID:
- Mussi P, Yu C, O'Malley BW, Xu J "." Mol. Endocrinol.. 2006 Dec;20(12):3105-19. Pubmed PMID:
- Mussi P, Liao L, Park SE, Ciana P, Maggi A, Katzenellenbogen BS, Xu J, O'Malley BW "." Proc. Natl. Acad. Sci. U.S.A.. 2006 Nov 7;103(45):16716-21. Pubmed PMID:
- Yu C, York B, Wang S, Feng Q, Xu J, O'Malley BW "." Mol. Cell. 2007 Mar 9;25(5):765-78. Pubmed PMID:
- Yuan Y, Xu J "." Arterioscler. Thromb. Vasc. Biol.. 2007 Jul;27(7):1521-7. Pubmed PMID:
- Liao L, Chen X, Wang S, Parlow AF, Xu J "." Mol. Cell. Biol.. 2008 Apr;28(7):2460-9. Pubmed PMID:
- Liu Z, Liao L, Zhou S, Xu J "." Int. J. Biol. Sci.. 2008;4(4):202-7. Pubmed PMID:
- Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW "." Science. 2008 Nov 28;322(5906):1395-9. Pubmed PMID:
- York B, Yu C, Sagen JV, Liu Z, Nikolai BC, Wu RC, Finegold M, Xu J, O'Malley BW "." Proc. Natl. Acad. Sci. U.S.A.. 2010 Jun 15;107(24):11122-7. Pubmed PMID:
- York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O鈥橫alley BW "Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy." Cell Metab. 2012;15(5):752-63.
- Zhou J, Qin L, Gao L, Chen X, Tien JCY, Wang F, Hsieh J-T, Xu J "Nkx3.1 functions as a 鈥淧ara-Transcription Factor鈥 to regulate gene expression and cell proliferation in a non-cell-autonomous manner." J Biol Chem. 2012;287:17248-56.
- Chen LY, Zhang Y, Zhang Q, Li H, Luo Z, Fang H, Kim SH, Qin L, Yotnda P, Xu J, Tu BP, Bai Y, Songyang Z "Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control." Mol Cell. 2012;47(6):839-50.
- Kawagoe J, Li Q, Mussi P, Liao L, Lydon JP, DeMayo FJ and Xu J "Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation." Dev Cell. 2012;23:858-65.
- Tien JC, Liu Z, Liao L, Wang F, Xu Y, Wu YL, Zhou N, Ittmann M, Xu J "The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer." Cancer Res. 2013;73(13):3997-4008.
- Xu Y, Xu Y, Liao L, Zhou Z, Theissen S, Liao X-H, Nguyen H, Ludwig T, Qin L, Martinez J, Jiang J, Xu J "Inducible knockout of Twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting Twist1 as a preferential cancer target." Am J Pathol. 2013;183(4):1281-92.
- Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BW "Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1." Cancer Res. 2014;74(5):1506-17.
- Qin L, Wu YL, Toneff MJ, Li D, Liao L, Gao X, Bane FT, Tien J, Xu Y, Feng Z, Yang Z, Xu Y, Theissen SM, Li Y, Young L, Xu J "NCOA1 directly targets M-CSF1 expression to promote breast cancer metastasis." Cancer Res. 2014;74:3477-88.
- Lee DK, Liu Y, Liao L, Wang F, Xu J "The prostate basal cell (BC) heterogeneity and the p63-positive BC differentiation spectrum in mice." Int J Biol Sci. 2014;10(9):1007-17.
- Tien J, Liao L, Liu Y, Liu Z, Lee DK, Wang F, Xu J "The steroid receptor coactivator-3 is required for developing neuroendocrine tumor in mice." Int J Biol Sci. 2014;10(10):1116-27.
- Ma G, He J, Yu Y, Xu Y, Yu X, Martinez J, Lonard DM, Xu J "Tamoxifen Inhibits ER-negative Breast Cancer Cell Invasion and Metastasis by Accelerating Twist1 Degradation." Int J Biol Sci. 2015;11(5):618-28.
- Wang L, Yu Y, Chow DC, Yan F, Hsu CC, Stossi F, Mancini MA, Palzkill T, Liao L, Zhou S, Xu J, Lonard DM, O鈥橫alley BW "Overactivation of the p160 SRCs by the small molecular inhibitor MCB-613 causes cancer cell stress and paraptosis." Cancer Cell. 2015;28(2):240-52.
- Gao L, Rabbitt EH, Condon JC, Renthal NE, Mitsche MA, Chambon P, Xu J, O鈥橫alley BW, Mendelson CR "Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition." J Clin Invest. 2015;125(7):2808-24.
- Qin L, Xu Y, Xu Y, Ma G, Liao L, Wu Y, Li Y, Wang X, Wang X, Jiang J, Wang J, Xu J "NCOA1 Promotes Angiogenesis in Breast Tumors by Simultaneously Enhancing both HIF1伪- and AP-1-mediated VEGFa Transcription." Oncotarget. 2015;6(27):11518-28.
- Sun T, Fu J, Shen T, Lin X, Liao L, Feng XH, Xu J "The small C-terminal domain phosphatase 1 inhibits cancer cell migration and invasion by dephosphorylating phospho-Ser68-Twist1 to accelerate Twist1 degradation." J Biol Chem. 2015;291(22):11518-28.
- Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O鈥橫alley BW, Wang J "Development of potent small-molecular inhibitors to drug the undruggable steroid receptor coactivator-3." Proc Natl Acad Sci USA. 2016;113(18):4970-5.
- Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH "Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumour initiation." Nat Cell Biol. 2016;18(6):632-44.
- Xu Y, Qin L, Sun T, Wu H, He T, Yang Z, Mo Q, Liao L, Xu J "Twist1 Promotes Breast Cancer Invasion and Metastasis by Silencing Foxa1 Expression. Oncogene." Oncogene. 2016;36(8):1157-66.
- Shi E, Kan M, Xu JM, McKeehan WL "." J. Biol. Chem.. 1991 Mar 25;266(9):5774-9. Pubmed PMID:
- Yu X, Xu J "A 鈥済oldmine鈥 for digging cancer-specific targets: the genes essential for embryonic development but nonessential for adult life." J Mol Cell Biol. 2020;12(9):669-73.
- Kruse RL, Barzi M, Legras X, Pankowicz FP, Furey N, Liao L, Xu J, Bissig-Choisat B, Slagle BL, Bissig K-D "A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome." JHEP Reports. 2021;3(2):100252.
- Dearth RK, Kuiatse I, Wang YF, Liao L, Hilsenbeck SG, Brown PH, Xu J, Lee AV "." BMC Cancer. 2011;11:377. Pubmed PMID:
- Liao L, Kuang SQ, Yuan YH, Xu JM "." Shi Yan Sheng Wu Xue Bao. 2002 Sep;35(3):163-8. Pubmed PMID:
- Hartmaier RJ, Richter AS, Gillihan RM, Sallit JZ, McGuire SE, Wang J, Lee AV, Osborne CK, O'Malley BW, Brown PH, Xu J, Skaar TC, Philips S, Rae JM, Azzouz F, Li L, Hayden J, Henry NL, Nguyen AT, Stearns V, Hayes DF, Flockhart DA, Oesterreich S "." Mol. Endocrinol.. 2012 Feb;26(2):220-7. Pubmed PMID:
- Matsuzaki K, Xu J, Wang F, McKeehan WL, Krummen L, Kan M "." J. Biol. Chem.. 1993 Jun 15;268(17):12719-23. Pubmed PMID:
- Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, and Rajagopal J "Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells." Science. 2021;371(6524):52-7.
- Gatza CE, Dumble M, Kittrell F, Edwards DG, Dearth RK, Lee AV, Xu J, Medina D, Donehower LA "." Dev. Biol.. 2008 Jan 1;313(1):130-41. Pubmed PMID:
- Wang F, Kan M, Yan G, Xu J, McKeehan WL "." J. Biol. Chem.. 1995 Apr 28;270(17):10231-5. Pubmed PMID:
- Kan M, Wang F, Xu J, Crabb JW, Hou J, McKeehan WL "." Science. 1993 Mar 26;259(5103):1918-21. Pubmed PMID:
- He Y, Hooker E, Yu EJ, Cunha G, Liao L, Xu J, Earl A, Wu H, Gonzalgo M, Sun Z "Androgen signaling is essential for development of prostate cancer initiated from prostate basal cells." Oncogene. 2019;38(13):2337-50.
- Wang Z, Zhang F, He J, Wu P, Tay LWR, Cai M, Nian W, Wang Y, Qin L, Chang JT, McIntire LB, Di Paolo GD, Xu J, Peng J, Du G "Binding of PLD2-generated phosphatidic acid to KIF5B promotes MT1-MMP surface trafficking and lung metastasis of mouse breast cancer cells." Dev Cell. 2017;43(2):186-97.
- Xu Y, Lee D-K, Feng Z, Xu Ya, Bu W, Li Y, Liao L, Xu J "Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination and lung metastasis in mice." Proc Natl Acad Sci USA. 2017;114(43):11494-99.
- Ding Y, Liu Y, Lee, D-K, Tong Z, Yu X, Li Y, Xu Y, Lanz R, O鈥橫alley BW, Xu J "Cell lineage tracing links ER飦 loss in Erbb2-induced breast cancer cells to the arising of a highly proliferative and metastatic breast cancer subtype." Proc Natl Acad Sci USA. 2021;118(21):e2100673118.
- Viswakarma N, Jia Y, Bai L, Vluggens A, Borensztajn J, Xu J, Reddy JK "." PPAR Res. 2010;2010 Pubmed PMID:
- Lanza DG, Gaspero A, Lorenzo I, Liao L, Zheng P, Wang Y, Deng Y, Cheng C, Zhang C, Seavitt JR, DeMayo FJ, Xu J, Dickinson ME, Beaudet AL, Heaney JD "Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles." BMC Biology. 2018;16(1):69.
- Shi E, Kan M, Xu J, Wang F, Hou J, McKeehan WL "." Mol. Cell. Biol.. 1993 Jul;13(7):3907-18. Pubmed PMID:
- Ma X, Xu L, Wang S, Cui B, Li X, Xu J, Ning G "." J. Hepatol.. 2011 Aug;55(2):445-52. Pubmed PMID:
- Ying H, Furuya F, Willingham MC, Xu J, O'Malley BW, Cheng SY "." Mol. Cell. Biol.. 2005 Sep;25(17):7687-95. Pubmed PMID:
- Han SJ, Jeong J, Demayo FJ, Xu J, Tsai SY, Tsai MJ, O'Malley BW "." Mol. Cell. Biol.. 2005 Sep;25(18):8150-65. Pubmed PMID:
- M枚dder UI, Sanyal A, Kearns AE, Sibonga JD, Nishihara E, Xu J, O'Malley BW, Ritman EL, Riggs BL, Spelsberg TC, Khosla S "." Endocrinology. 2004 Feb;145(2):913-21. Pubmed PMID:
- Xu J, Nakahara M, Crabb JW, Shi E, Matuo Y, Fraser M, Kan M, Hou J, McKeehan WL "." J. Biol. Chem.. 1992 Sep 5;267(25):17792-803. Pubmed PMID:
- Yang Z, Wolf IM, Chen H, Periyasamy S, Chen Z, Yong W, Shi S, Zhao W, Xu J, Srivastava A, S谩nchez ER, Shou W "." Mol. Endocrinol.. 2006 Nov;20(11):2682-94. Pubmed PMID:
- Zhang P, Chen Y, Gong M, Zhuang Z, Wang Y, Mu L, Wang T, Pan J, Liu Y, Xu J, Liang R, Yuan Y "Gab2 Regulates the Stemness of HER2-overexpressed Breast Cancer Cell." Cell Physiol Biochem. 2018;50:52-65.
- Xiao Y, Xu J, Wang S, Mao C, Jin M, Ning G, Xu J, Zhang Y "." Glia. 2010 Jun;58(8):932-42. Pubmed PMID:
- Song EC, Min S, Oyelakin A, Smalley K, Bard JE, Liao L, Xu J, Romano RA "Genetic and scRNA-seq Analysis Reveals Distinct Cell Populations that Contribute to Salivary Gland Development and Maintenance." Sci Rep. 2018;8(1):14043.
- Park SE, Xu J, Frolova A, Liao L, O'Malley BW, Katzenellenbogen BS "." Mol. Cell. Biol.. 2005 Mar;25(5):1989-99. Pubmed PMID:
- Xu J, Matsuzaki K, McKeehan K, Wang F, Kan M, McKeehan WL "." Proc. Natl. Acad. Sci. U.S.A.. 1994 Aug 16;91(17):7957-61. Pubmed PMID:
- Zerrad-Saadi A, Lambert-Blot M, Mitchell C, Bretes H, Collin de l'Hortet A, Baud V, Chereau F, Sotiropoulos A, Kopchick JJ, Liao L, Xu J, Gilgenkrantz H, Guidotti JE "." Endocrinology. 2011 Jul;152(7):2731-41. Pubmed PMID:
- McCartan D, Bolger JC, Fagan A, Byrne C, Hao Y, Qin L, McIlroy M, Xu J, Hill AD, Gaora P脫, Young LS "." Cancer Res.. 2012 Jan 1;72(1):220-9. Pubmed PMID:
- Sang M, Hulsurkar M, Zhang X, Song H, Zheng D, Zhang Y, Li M, Xu J, Zhang S, Ittmann M, Li W "GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells." Oncotarget. 2016;7(29):45171-85.
- Peng K, Su G, Ji J, Yang X, Miao M, Mo P, Li M, Xu J, Li W, Yu C "Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt/尾-catenin signaling." J Biol Chem. 2018;293(27):10606-19.
- Zhang QJ, Tran TAT, Wang M, Ranek MJ, Kokkonen-Simon KM, Gao J, Luo X, Tan W, Krychenko V, Liao L, Xu J, Hill JA, Olson EN, Kass DA, Martinez ED, and Liu Z-P "Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis." Nat Commun. 2018;9(1):5230.
- Li Q, Xu J "." Int. J. Biol. Sci.. 2011;7(5):505-16. Pubmed PMID:
- Xu J, Liao L, Qin J, Xu J, Liu D, Songyang Z "." J. Biol. Chem.. 2009 May 22;284(21):14377-85. Pubmed PMID:
- IJpenberg A, Tan NS, Gelman L, Kersten S, Seydoux J, Xu J, Metzger D, Canaple L, Chambon P, Wahli W, Desvergne B "." EMBO J.. 2004 May 19;23(10):2083-91. Pubmed PMID:
- Xu J, McKeehan K, Matsuzaki K, McKeehan WL "." J. Biol. Chem.. 1995 Mar 17;270(11):6308-13. Pubmed PMID:
- Prudovsky I, Savion N, Zhan X, Friesel R, Xu J, Hou J, McKeehan WL, Maciag T "." J. Biol. Chem.. 1994 Dec 16;269(50):31720-4. Pubmed PMID:
- Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW "." J. Biol. Chem.. 2004 Feb 20;279(8):7131-5. Pubmed PMID:
- McKeehan K, McKeehan WI, Xu J, Liao L "." In Vitro Cell. Dev. Biol. Anim.. 1996 Mar;32(3):131-4. Pubmed PMID:
- Zhang B, Ci X, Tao R, Ni J, Xuan X, King J, Xia S, Li Y, Frierson H, Lee D-K, Xu J, Osunkoya A, Dong JT "Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration." Nat Commun. 2020;11(1):997.
- Wang WL, Li Q, Xu J, Cvekl A "." Mol. Biol. Cell. 2010 Jul 15;21(14):2453-68. Pubmed PMID:
- Wang F, Kan M, Xu J, Yan G, McKeehan WL "." J. Biol. Chem.. 1995 Apr 28;270(17):10222-30. Pubmed PMID:
- Xi Y, Kim T, Brumwell AN, Driver I, Wei Y, Tan V, Jackson J, Xu J, Lee D-K, Gotts J, Matthay M, Shannon JM, Chapman HA, Vaughan AE "Local lung hypoxia determines epithelial fate decisions during alveolar regeneration." Nat Cell Biol. 2017;19(9):904-14.
- Ma X, Xu L, Wang S, Chen H, Xu J, Li X, Ning G "." Lab. Invest.. 2009 Aug;89(8):903-14. Pubmed PMID:
- Weiss RE, Xu J, Ning G, Pohlenz J, O'Malley BW, Refetoff S "." EMBO J.. 1999 Apr 1;18(7):1900-4. Pubmed PMID:
- Kamiya Y, Zhang XY, Ying H, Kato Y, Willingham MC, Xu J, O'Malley BW, Cheng SY "." Endocrinology. 2003 Sep;144(9):4144-53. Pubmed PMID:
- Xu J, O'Malley BW "." Rev Endocr Metab Disord. 2002 Sep;3(3):185-92. Pubmed PMID:
- Liao L, Kuang SQ, Yuan Y, Gonzalez SM, O'Malley BW, Xu J "." J. Steroid Biochem. Mol. Biol.. 2002 Dec;83(41279):41347. Pubmed PMID:
- Lee D-K, Liu Y, Liao L, Li W, Danielpour D, and Xu J "Neuroendocrine prostate carcinoma cells originate from the p63-expressing basal cells but not the pre-existing adenocarcinoma cells in mice." Cell Res. 2019;29(5):420-2.
- Wu HY, Hamamori Y, Xu J, Chang SC, Saluna T, Chang MF, O'Malley BW, Kedes L "." J. Biol. Chem.. 2005 Feb 4;280(5):3129-37. Pubmed PMID:
- Feng S, Xu J, Wang F, Kan M, McKeehan WL "." Biochim. Biophys. Acta. 1996 Jan 10;1310(1):67-73. Pubmed PMID:
- McKenna NJ, Xu J, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW "." J. Steroid Biochem. Mol. Biol..;69(41280):41345. Pubmed PMID:
- Nishihara E, O'Malley BW, Xu J "." Mol. Neurobiol.. 2004 Dec;30(3):307-25. Pubmed PMID:
- Wu H, Bi J, Peng Y, Huo L, Yu X, Yang Z, Zhou Y, Qin L, Xu Y, Liao L, Xie Y, Conneely OM, Jonkers J, Xu J "Nuclear Receptor NR4A1 Is a Tumor Suppressor Down-regulated in Triple-Negative Breast Cancer." Oncotarget. 2017;8:54364-77.
- Wang Y, Xu J, Pierson T, O'Malley BW, Tsai SY "." Gene Ther.. 1997 May;4(5):432-41. Pubmed PMID:
- Yuan B, Liu J, Cao J, Yu Y, Zhang H, Wang F, Zhu Y, Xiao M, Liu S, Ye Y, Ma L, Xu D, Xu N, Li Y, Zhao B, Xu P, Jin J, Xu J, Chen X, Shen L, Lin X, Feng XH "PTPN3 Acts as a Tumor Suppressor and Boosts TGF-尾 Signaling Independent of its Phosphatase Activity." EMBO J. 2019;38(14):e99945.
- Kan M, Yan GC, Xu J, Nakahara M, Hou J "." In Vitro Cell. Dev. Biol..;28(41463):515-20. Pubmed PMID:
- Xia J, Liao L, Sarkar J, Matsumoto K, Reddy JK, Xu J, Kemper B "." Arch. Biochem. Biophys.. 2007 Dec 1;468(1):49-57. Pubmed PMID:
- Sadow PM, Chassande O, Koo EK, Gauthier K, Samarut J, Xu J, O'Malley BW, Weiss RE "." Mol. Cell. Endocrinol.. 2003 May 30;203(41276):65-75. Pubmed PMID:
- Yeom SY, Kim GH, Kim CH, Jung HD, Kim SY, Park JY, Pak YK, Rhee DK, Kuang SQ, Xu J, Han DJ, Song DK, Lee JW, Lee KU, Kim SW "." Mol. Cell. Biol.. 2006 Jun;26(12):4553-63. Pubmed PMID:
- Tanaka K, Martinez GJ, Yan X, Long W, Ichiyama K, Chi X, Kim B-S, Reynolds JM, Chung Y, Tanaka S, Liao L, Nakanishi Y, Yoshimura A, Zheng P, Wang X, Tian Q, Xu J, O鈥橫alley BW, Dong C "Regulation of pathogenic T helper 17 cell differentiation by steroid receptor coactivator-3." Cell Reports. 2018;23(8):2318-29.
- Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW "." Mol. Cell. Biol.. 2002 May;22(10):3549-61. Pubmed PMID:
- Park S, Zhao Y, Yoon S, Xu J, Liao L, Lydon J, DeMayo F, O'Malley BW, Katzenellenbogen BS "." Endocrinology. 2011 Nov;152(11):4336-49. Pubmed PMID:
- Yu X, Yustein JT, Xu J "Research models and mesenchymal/epithelial plasticity of osteosarcoma." Cell & Biosci. 2021;11:94.
- Al-Otaiby M, Tassi E, Schmidt MO, Chien CD, Baker T, Ganoza Salas A, Xu J, Furlong M, Schlegel R, Riegel AT, Wellstein A "." 2012 Feb 14; Pubmed PMID:
- Ye X, Han SJ, Tsai SY, DeMayo FJ, Xu J, Tsai MJ, O'Malley BW "." Proc. Natl. Acad. Sci. U.S.A.. 2005 Jul 5;102(27):9487-92. Pubmed PMID:
- Yang Y, Riccio P, Schotsaert M, Mori M, Lu J, Lee DK, Garc铆a-Sastre A, Xu J, Cardoso WV "Spatial-temporal lineage restrictions of embryonic p63+ progenitors establish distinct stem cell pools in adult airways." Dev Cell. 2018;44(6):752-61.
- Sadow PM, Chassande O, Gauthier K, Samarut J, Xu J, O'Malley BW, Weiss RE "." Am. J. Physiol. Endocrinol. Metab.. 2003 Jan;284(1):E36-46. Pubmed PMID:
- Hinton AO Jr, Yang Y, Quick A, Xu P, Reddy CL, Yan X, Reynolds C, Tong Q, Zhu L, Xu J, Wehrens X, Xu Y, Reddy AK "SRC-1 regulates blood pressure and aortic stiffness in female mice." PLoS One. 2016;11(12):e0168644.
- Xia X, Chen Y, Xu J, Yu C, Chen W "SRC-3 deficiency protects host from Listeria monocytogenes infection through increasing ROS production and decreasing lymphocyte apoptosis. International Immunopharmacology." Int Immunopharmacol. 2021;96:107625.
- Xu L, Ma X, Li J, Li X, Xu J, Wang S, Ning G "." Endocrine. 2010 Aug;38(1):60-6. Pubmed PMID:
- Chen T, Chen Q, Xu Y, Zhou Q, Zhu J, Zhang H, Wu Q, Xu J, Yu C "." J. Hepatol.. 2012 Jan;56(1):210-7. Pubmed PMID:
- Chen W, Zhuo M, Lu X, Xia X, Zhao Y, Huang Z, Xu J, Li W, Yu C "SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression." Int J Biol Sci. 2018;14(14):2051-64.
- Sen S, Wang F, Zhang J, He Z, Ma J, Gwack Y, Xu J, Sun Z "SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate ROR飦 activity in a PKC-胃-dependent manner." Proc Natl Acad Sci USA. 2017;115(3):E458-67.
- He Z, Zhang J, Du Q, Xu J, Gwack Y, and Sun Z "SRC3 is a cofactor for ROR飦 in Th17 differentiation but not thymocyte development." J Immunol. 2019;202(3):760-9.
- Han SJ, DeMayo FJ, Xu J, Tsai SY, Tsai MJ, O'Malley BW "." Mol. Endocrinol.. 2006 Jan;20(1):45-55. Pubmed PMID:
- Chen W, Lu X, Chen Y, Li M, Mo P, Tong Z, Wang W, Wan W, Su G, Xu J, Yu C "Steroid receptor coactivator 3 contributes to host defense against enteric bacteria by recruiting neutrophils via upregulation of CXCL2 expression." J Immunol. 2017;198(4):1606-15.
- Li M, Wang Y, Xia X, Mo P, Xu J, Yu C and Li W "Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4飦 nuclear translocation." Cell Biosci. 2019;9:64.
- Chen Q, Chen T, Xu Y, Zhu J, Jiang Y, Zhao Y, Xu J, Yu C "." J. Immunol.. 2010 Nov 1;185(9):5444-52. Pubmed PMID:
- Takeuchi Y, Murata Y, Sadow P, Hayashi Y, Seo H, Xu J, O'Malley BW, Weiss RE, Refetoff S "." Endocrinology. 2002 Apr;143(4):1346-52. Pubmed PMID:
- Lachize S, Apostolakis EM, van der Laan S, Tijssen AM, Xu J, de Kloet ER, Meijer OC "." Proc. Natl. Acad. Sci. U.S.A.. 2009 May 12;106(19):8038-42. Pubmed PMID:
- Monks DA, Xu J, O'Malley BW, Jordan CL "." Neuroendocrinology. 2003 Jul;78(1):45-51. Pubmed PMID:
- Yang, van der Klaauw, Zhu, Cacciottolo, He, Stadler, Wang, Xu, Saito, Hinton Jr., Yan, Keogh, Henning, Banton, Hendricks, Bochukova, Mistry, Lawler, Liao, Xu, O鈥橰ahilly, Tong, Barroso, O鈥橫alley, Farooqi, Xu "Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis." Nat Commun. 2019;10(1):1718.
- Winnay JN, Xu J, O'Malley BW, Hammer GD "." Endocrinology. 2006 Mar;147(3):1322-32. Pubmed PMID:
- Tien JC, Xu J "." Expert Opin. Ther. Targets. 2012 Nov;16(11):1085-96. Pubmed PMID:
- Zou K, Chen W, Dai J, Mo P, Yu C, Xu J, Wu S, Zhou S, Su G "Steroid receptor coactivator-3 is required for inhibition of the intestinal muscularis inflammatory response of postoperative ileus in mice." Inflammation. 2021;44(3):1145-59.
- Ning G, Jurecic V, Baldini A, Xu J "." In Vitro Cell. Dev. Biol. Anim.. 1999 Sep;35(8):481-6. Pubmed PMID:
- Hou J, Kan M, Wang F, Xu JM, Nakahara M, McBride G, McKeehan K, McKeehan WL "." J. Biol. Chem.. 1992 Sep 5;267(25):17804-8. Pubmed PMID:
- Liu S, Long J, Yuan B, Zheng M, Xiao M, Xu J, Lin X, Feng XH "SUMO modification reverses inhibitory effects of Smad nuclear interacting protein-1 in TGF-beta responses." J Biol Chem. 2016;291(47):24418-30.
- Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O鈥橫alley BW "Targeting SRC coactivators blocks the tumor-initiating capacity of cancer stem-like cells." Cancer Res. 2017;77(16):4293-304.
- Qin L, Xu Y, Yu X, Toneff M, Li D, Liao L, Martinez J, Li Y, Xu J "The histone demethylase Kdm3a is required for normal epithelial proliferation, ductal elongation and tumor growth in the mouse mammary gland." Oncotarget. 2017;8(49):84761-75.
- Fereshteh MP, Tilli MT, Kim SE, Xu J, O'Malley BW, Wellstein A, Furth PA, Riegel AT "." Cancer Res.. 2008 May 15;68(10):3697-706. Pubmed PMID:
- Tien JC, Zhou S, Xu J "." Int. J. Biol. Sci.. 2009;5(3):256-64. Pubmed PMID:
- Xu J "." Nucl Recept Signal. 2003;1:e002. Pubmed PMID:
- M枚dder UI, Sanyal A, Xu J, O'Malley BW, Spelsberg TC, Khosla S "." Bone. 2008 Feb;42(2):414-21. Pubmed PMID:
- Tong Z, Liu Y, Yu X, Martinez J, Xu J "The transcriptional co-activator NCOA6 promotes estrogen-induced GREB1 transcription by recruiting ER飦 and enhancing enhancer-promoter interaction." J Biol Chem. 2019;294(51):19667-82.
- Weiss RE, Gehin M, Xu J, Sadow PM, O'Malley BW, Chambon P, Refetoff S "." Endocrinology. 2002 Apr;143(4):1554-7. Pubmed PMID:
- Sadow PM, Koo E, Chassande O, Gauthier K, Samarut J, Xu J, O'Malley BW, Seo H, Murata Y, Weiss RE "." Mol. Endocrinol.. 2003 May;17(5):882-94. Pubmed PMID:
- Yang M, Yu X, Li X, Luo B, Yang W, Lin Y, Li D, Gan Z, Xu J, He T "TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells." Breast Cancer Res. 2018;20(1):97.
- Jiang M, Li H, Zhang Y, Yang Y, Lu R, Liu K, Lin S, Lan X, Wang H, Wu H, Zhu J, Zhou Z, Xu J, Lee D-K, Zhang L, Lee YC, Yuan J, Abrams JA, Wang TC, Sepulveda AR, Wu Q, Chen H, Sun X She J, Chen X, Que J "Transitional basal cells at the squamous-columnar junction generate Barrett鈥檚 esophagus." Nature. 2017;550(7677):529-33.
- Li C, Ao J, Fu J, Lee DF, Xu J, Lonard D, O'Malley BW "." Oncogene. 2011 Oct 20;30(42):4350-64. Pubmed PMID:
- Farrelly O, Suzuki-Horiuchi Y, Brewster M, Kuri P, Huang S, Rice G, Bae H, Xu J, Dentchev T, Lee V, Rompolas P "Two-photon live imaging of single cornieal stem cells reveals compartmentalized organization of the limbal niche." Cell Stem Cell. 2021;28(7):1233-47.
- Oh AS, Lahusen JT, Chien CD, Fereshteh MP, Zhang X, Dakshanamurthy S, Xu J, Kagan BL, Wellstein A, Riegel AT "." Mol. Cell. Biol.. 2008 Nov;28(21):6580-93. Pubmed PMID:
- Sreekumar A, Toneff MJ, Toh E, Roarty K, Creighton CJ, Belka GK, Lee D-K, Xu J, Chodosh LA, Richards JS, Rosen JM "WNT-mediated regulation of FOXO1 Constitutes a critical axis maintaining pubertal mammary stem cell homeostasis." Dev Cell. 2017;43(4):436-48.
to edit your profile
