Ignatia Barbara Van den Veyver, M.D.
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Positions
- Professor
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Obstetrics and Gynecology
Maternal Fetal Medicine
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Houston, TX US
- Professor
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Molecular and Human Genetics
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Houston, Texas United States
- Director of Clinical Prenatal & Reproductive Genetics
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Molecular & Human Genetics
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Houston, Texas United States
- Director
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Clinical Translational Research Certificate of Added Qualification (CTR-CAQ) program
- Member
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Dan L Duncan Comprehensive Cancer Center
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Houston, Texas United States
- Faculty Member
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Graduate Programs in Development, Disease Models & Therapeutics and Genetics & Genomics
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Addresses
- Jan & Dan Duncan Neurological (Office)
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Room: NRI-1025.14
Houston, TX 77030
United States
Phone: (832) 824-8156
iveyver@bcm.edu
- Texas Children's Hospital Pavilion for Women (Clinic)
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6651 Main Street Suite F420
Houston, TX 77030
United States
Phone: (832) 826-7500
obgyn@bcm.edu
Education
- Fellowship at Baylor College Of Medicine
- 06/1993 - Houston, Texas United States
- Maternal-Fetal Medicine
- MD from University of Antwerp
- 07/1986 - Antwerp, Belgium
- Residency at University Of Antwerp affiliated hospitals
- 07/1991 - Antwerp, Belgium
- Obstetrics and Gynecology
- Clinical Fellowship at Baylor College Of Medicine
- 06/1996 - Houston, Texas United States
- Genetics
Professional Interests
- Genetics and epigenetics of reproductive disorders; Aicardi syndrome; prenatal gene-environment interactions; prenatal genetics
Professional Statement
As a physician-scientist, my research includes translational and basic research on the molecular genetics and epigenetics of human developmental and reproductive disorders with the ultimate goal of improving the diagnosis and treatment for these conditions.Integrating clinical research with experiments in cell lines and mouse models, my lab studies maternal effect gene mutations that cause a range of health issues from infertility to pregnancy loss with multi-locus imprinting abnormalities, including molar pregnancies, and offspring with an array of birth defects.
We also do genetic research towards finding the cause of Aicardi syndrome, a rare neurodevelopmental disorder in girls that affects development of eyes and brain, causing severe seizures, and intellectual and developmental disability.
My clinical role as Director of Prenatal and Reproductive Genetics gives a unique perspective on my translational research which focuses on exploring novel methods for reproductive and prenatal genetic screening and testing, and the complexities of their integration into preconception and prenatal and perinatal care. I participated in the development and early implementation of chromosomal microarray analysis (CMA) for prenatal diagnosis and in the earliest studies on exome sequencing for prenatal diagnosis. Today, I serve as a co-PI on the large multicenter PrenatalSEQ study which evaluates different aspects of whole genome sequencing for prenatal diagnosis, including detection rates, outcomes, and psychosocial impacts of obtaining a genetic diagnosis using this new test. We are also studying new approaches for non-invasive screening for fetal chromosomal and single gene disorders, including development and validation of methods for non-invasive prenatal diagnosis using circulating fetal cells, cell-free DNA and other non-invasive markers of fetal health.
As an active translational research educator, I am passionate about mentoring the research of postdoctoral researchers, clinical fellows, junior faculty and graduate students. After being co-director for more than ten years of a graduate program in translational research, I launched a new Clinical Translational Research Certificate of Added Qualification (CTR-CAQ) program that aims to integrate translational research training into the graduate school curriculum and is funded in part by a Ruth L. Kirschstein Institutional National Research Service Award (T32).
My roles as researcher, clinician and educator positively impact my leadership in the field of prenatal genetics. I served as president of the International Society for Prenatal Diagnosis (2016-2018), and I am currently an associate editor of Prenatal Diagnosis, and co-chair of the ClinGen Prenatal Gene Curation Expert Panel, focused on better understanding the gene variants impacting non-immune hydrops, other severe prenatal conditions, and stillbirth.
Websites
Selected Publications
- Crovetti B, Maktabi MA, Erfani H, Panchalee T, Wang Q, Vossaert L, Van den Veyver I "." Prenat Diagn.. 2021;42:1182-9. Pubmed PMID:
- Anvar Z, Chakchouk I, Demond H, Sharif M, Kelsey G, Van den Veyver IB "." Genes (Basel). 2021;12:1214. Pubmed PMID:
- Mahadevan S, Sathappan V, Utama B, Lorenzo I, Kaskar K, Van den Veyver IB "." Sci Rep.. 2017;7:44667. Pubmed PMID:
- Wang X, Sutton VR, Eble TN, Lewis RA, Gunaratne P, Patel A, Van den Veyver IB "." Am J Med Genet A. 2009 Oct;149(10):2113-21. Pubmed PMID:
- Kou YC, Shao L, Peng HH, Rosetta R, del Gaudio D, Wagner AF, Al-Hussaini TK, Van den Veyver IB "." Mol. Hum. Reprod.. 2008 Jan;14(1):33-40. Pubmed PMID:
- Balasa A, Sanchez-Valle A, Sadikovic B, Sangi-Haghpeykar H, Bravo J, Chen L, Liu W, Wen S, Fiorotto ML, Van den Veyver IB "." J Nutr. 2011 Dec;141(12):2106-12. Pubmed PMID:
- Liu W, Shaver TM, Balasa A, Ljungberg MC, Wang X, Wen S, Nguyen H, Van den Veyver IB "." PLoS ONE. 2012;7(3):e32331. Pubmed PMID:
- Sutton VR, Hopkins BJ, Eble TN, Gambhir N, Lewis RA, Van den Veyver IB "." Am. J. Med. Genet. A. 2005 Oct 15;138(3):254-8. Pubmed PMID:
- Moglabey YB, Kircheisen R, Seoud M, El Mogharbel N, Van den Veyver I, Slim R "." Hum. Mol. Genet.. 1999 Apr;8(4):667-71. Pubmed PMID:
- Van den Veyver IB "." Cytogenet. Genome Res.. 2002;99(41278):289-96. Pubmed PMID:
- Wang X, Reid Sutton V, Omar Peraza-Llanes J, Yu Z, Rosetta R, Kou YC, Eble TN, Patel A, Thaller C, Fang P, Van den Veyver IB "." Nat Genet. 2007 Jul;39(7):836-8. Pubmed PMID:
- Hopkins B, Sutton VR, Lewis RA, Van den Veyver I, Clark G "." Am. J. Med. Genet. A. 2008 Nov 15;146(22):2871-8. Pubmed PMID:
- Mahadevan S, Wen S, Wan Y-W, Peng H-H, Otta S, Liu Z, Iacovino M, Mahen EM, Kyba M, Sadikovic B, Van den Veyver IB "." Hum Mol Genet. 2014;23(3):706-16. Pubmed PMID:
- Mahadevan SK, Wen S, Balasa A, Fruhman G, Mateus J, Wagner A, Al-Hussaini T, Van den Veyver IB "." Prenat Diagn. 2013;33(13):1242-7. Pubmed PMID:
- Eble TN, Sutton VR, Sangi-Haghpeykar H, Wang X, Jin W, Lewis RA, Fang P, Van den Veyver IB "." Hum Genet. 2009 Mar;125(2):211-6. Pubmed PMID:
- Fruhman G, Eble TN, Gambhir N, Sutton VR, Van den Veyver IB, Lewis RA "." J AAPOS. 2012 Jun;16(3):238-41. Pubmed PMID:
- Breman A, Pursley AN, Hixson P, Bi W, Ward P, Bacino CA, Shaw C, Lupski JR, Beaudet A, Patel A, Cheung SW, Van den Veyver I "." Prenat Diagn. 2012 Apr;32(4):351-61. Pubmed PMID:
- Emrick LT, Murphy L, Shamshirsaz AA, Ruano R, Cassady CI, Liu L, Chang F, Sutton VR, Li M, Van den Veyver IB. "." Am J Med Genet A. 2014 Jul 14; Pubmed PMID:
- Van den Veyver IB, Panichkul PP, Antalffy BA, Sun Y, Hunter JV, Armstrong DD "." Pediatr. Neurol.. 2004 Jan;30(1):41470. Pubmed PMID:
- Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY "." Nat. Genet.. 1999 Oct;23(2):185-8. Pubmed PMID:
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