Positions
- Professor Emeritus
-
Department of Neuroscience
草榴社区入口
Houston, TX US
Education
- Post-Doctoral Fellowship at Harvard Medical School
- 01/1983 - Boston, Massachusetts United States
- PhD from University Of Texas Medical School At Galveston
- 01/1980 - Galveston, Texas United States
- MA from University Of Texas At Austin
- 01/1975 - Austin, Texas United States
- BA from University Of Texas At Austin
- 01/1973 - Austin, Texas United States
- BA from Texas Tech University
- 09/1972 - Lubbock, Texas United States
Professional Interests
- Gene therapy of the nervous system
- Spinal Cord Injury
- Neuroimmunology of neural trauma
Professional Statement
The research interests of our laboratory focus on the molecular and cellular bases of disease and trauma of the nervous system with a translational emphasis. Our primary research emphasis is the study of the role of neurotrophic factors in CNS degeneration and regeneration as a consequence of trauma or neurodegenerative disease and their possible therapeutic use. Using viral vectors carrying genes for neurotrophic factors we have shown in animal models of CNS injury we can spare neurons from axotomy-induced neuronal death and support axonal sprouting after neural injury. Recently, we learned that neuroinflammation is required for regenerative effects of the neurotrophic factors and are now studying this phenomenon to determine its mechanism.Techniques used in the laboratory span from gene cloning, through small animal neurosurgery, light and confocal microscopy, neuroimmunology, to animal behavior.
Websites
Selected Publications
- Chen, Q and Shine, HD "Neuroimmune processes associated with Wallerian degeneration support neurotrophin-3-induced axonal sprouting in the injured spinal cord.." J Neurosci Res. 2013;91:1280-1291.
- Chen Q, Smith GM, Shine HD "." Exp. Neurol.. 2008 Feb;209(2):497-509. Pubmed PMID:
- Chen Q, Zhou L, Shine HD "." J. Neurotrauma. 2006 Aug;23(8):1254-60. Pubmed PMID:
- Zhou L, Shine HD "." J. Neurosci. Res.. 2003 Oct 15;74(2):221-6. Pubmed PMID:
- Castro RF, Jackson KA, Goodell MA, Robertson CS, Liu H, Shine HD "." Science. 2002 Aug 23;297(5585):1299. Pubmed PMID:
- Popko B, Puckett C, Lai E, Shine HD, Readhead C, Takahashi N, Hunt SW, Sidman RL, Hood L "." Cell. 1987 Feb 27;48(4):713-21. Pubmed PMID:
- Readhead C, Popko B, Takahashi N, Shine HD, Saavedra RA, Sidman RL, Hood L "." Cell. 1987 Feb 27;48(4):703-12. Pubmed PMID:
- Shine HD, Hertz L, De Vellis J, Haber B "." Neurochem. Res.. 1981 Apr;6(4):453-63. Pubmed PMID:
- Shine HD, Perez-Polo JR "." J. Neurochem.. 1976 Mar;26(3):513-9. Pubmed PMID:
- Goodman JC, Trask TW, Chen SH, Woo SL, Grossman RG, Carey KD, Hubbard GB, Carrier DA, Rajagopalan S, Aguilar-Cordova E, Shine HD "." Hum. Gene Ther.. 1996 Jun 20;7(10):1241-50. Pubmed PMID:
- Colak A, Goodman JC, Chen SH, Woo SL, Grossman RG, Shine HD "." Brain Res.. 1995 Sep 11;691(41276):76-82. Pubmed PMID:
- Colak A, Goodman JC, Chen SH, Woo SL, Grossman RG, Shine HD "." Hum. Gene Ther.. 1995 Oct;6(10):1317-22. Pubmed PMID:
- Perez-Cruet MJ, Trask TW, Chen SH, Goodman JC, Woo SL, Grossman RG, Shine HD "." J. Neurosci. Res.. 1994 Nov 1;39(4):506-11. Pubmed PMID:
- Kirkpatrick LL, Witt AS, Payne HR, Shine HD, Brady ST "." J. Neurosci.. 2001 Apr 1;21(7):2288-97. Pubmed PMID:
- Macklis JD, Sidman RL, Shine HD "." In Vitro Cell. Dev. Biol.. 1985 Mar;21(3):189-94. Pubmed PMID:
- Shine HD, Harcourt PG, Sidman RL "." J. Neurosci. Res.. 1985;14(4):393-401. Pubmed PMID:
- Jensen NA, Smith GM, Garvey JS, Shine HD, Hood L "." J. Neurosci. Res.. 1993 Jun 15;35(3):288-96. Pubmed PMID:
- Baumgartner BJ, Shine HD "." J. Neurosci. Res.. 1998 Dec 15;54(6):766-77. Pubmed PMID:
- Jensen NA, Smith GM, Shine HD, Garvey JS, Hood L "." J. Neurosci. Res.. 1993 Feb 15;34(3):257-64. Pubmed PMID:
- Sivaraman L, Gay J, Hilsenbeck SG, Shine HD, Conneely OM, Medina D, O'Malley BW "." Breast Cancer Res. Treat.. 2002 May;73(1):75-83. Pubmed PMID:
- Chen SH, Shine HD, Goodman JC, Grossman RG, Woo SL "." Proc. Natl. Acad. Sci. U.S.A.. 1994 Apr 12;91(8):3054-7. Pubmed PMID:
- Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SC "." Exp. Eye Res.. 2008 Dec;87(6):580-6. Pubmed PMID:
- Shine HD, Haber B "." Brain Res.. 1981 Aug 3;217(2):339-49. Pubmed PMID:
- Smith GM, Shine HD "." Int. J. Dev. Neurosci.. 1992 Oct;10(5):387-92. Pubmed PMID:
- Shine HD, Sidman RL "." J. Cell Biol.. 1984 Apr;98(4):1291-5. Pubmed PMID:
- Zou L, Yuan X, Long Y, Shine HD, Yang K "." Hum. Gene Ther.. 2002 Dec 10;13(18):2173-84. Pubmed PMID:
- Grider MH, Mamounas LA, Le W, Shine HD "." J. Neurosci. Res.. 2005 Nov 1;82(3):404-12. Pubmed PMID:
- Ayala GE, Wheeler TM, Shine HD, Schmelz M, Frolov A, Chakraborty S, Rowley D "." Prostate. 2001 Nov 1;49(3):213-23. Pubmed PMID:
- Grider MH, Park D, Spencer DM, Shine HD "." J. Neurosci. Res.. 2009 Nov 1;87(14):3033-42. Pubmed PMID:
- Shine HD, Readhead C, Popko B, Hood L, Sidman RL "." J. Neurochem.. 1992 Jan;58(1):342-9. Pubmed PMID:
- Shine HD, Readhead C, Popko B, Hood L, Sidman RL "." Prog. Clin. Biol. Res.. 1990;336:81-92. Pubmed PMID:
- Qi H, Li DQ, Shine HD, Chen Z, Yoon KC, Jones DB, Pflugfelder SC "." Exp. Eye Res.. 2008 Jan;86(1):34-40. Pubmed PMID:
- Baumgartner BJ, Shine HD "." Exp. Neurol.. 1998 Sep;153(1):102-12. Pubmed PMID:
- Shine HD, Wyde PR, Aguilar-Cordova E, Chen SH, Woo SL, Grossman RG, Goodman JC "." Gene Ther.. 1997 Apr;4(4):275-9. Pubmed PMID:
- Zhou L, Baumgartner BJ, Hill-Felberg SJ, McGowen LR, Shine HD "." J. Neurosci.. 2003 Feb 15;23(4):1424-31. Pubmed PMID:
- S谩nchez I, Hassinger L, Paskevich PA, Shine HD, Nixon RA "." J. Neurosci.. 1996 Aug 15;16(16):5095-105. Pubmed PMID:
- Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQ "." Mol. Vis.. 2007;13:1934-41. Pubmed PMID:
- Rabinovsky ED, Smith GM, Browder DP, Shine HD, McManaman JL "." J. Neurosci. Res.. 1992 Jan;31(1):188-92. Pubmed PMID:
- Trask TW, Trask RP, Aguilar-Cordova E, Shine HD, Wyde PR, Goodman JC, Hamilton WJ, Rojas-Martinez A, Chen SH, Woo SL, Grossman RG "." Mol. Ther.. 2000 Feb;1(2):195-203. Pubmed PMID:
- Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, Shine HD, Lindsey RW, Hirschi KK, Goodell MA, Brenner MK, Davis AR "." Proc. Natl. Acad. Sci. U.S.A.. 2003 Dec 23;100(26):15877-82. Pubmed PMID:
- Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S "." Cancer Res.. 2007 Jun 15;67(12):5957-64. Pubmed PMID:
- Readhead C, Takasashi N, Shine HD, Saavedra R, Sidman R, Hood L "." Ann. N. Y. Acad. Sci.. 1990;605:280-5. Pubmed PMID:
- Grider MH, Chen Q, Shine HD "." J. Neurosci. Methods. 2006 Sep 15;155(2):172-9. Pubmed PMID:
- Baumgartner BJ, Shine HD "." J. Neurosci.. 1997 Sep 1;17(17):6504-11. Pubmed PMID:
- Smith GM, Rabinovsky ED, McManaman JL, Shine HD "." Exp. Neurol.. 1993 Jun;121(2):239-47. Pubmed PMID:
- Shine HD, Perez-Polo JR "." J. Neurochem.. 1976 Dec;27(6):1315-8. Pubmed PMID:
Funding
- Identification of T cell subtypes necessary for NT-3 induced neuroplasticity using a novel human-to-rat graft strategy Mission Connect
- Inflammation-associated factors that support neuroplasticity in chronic spinal cord injury Christopher and Dana Reeve Foundation
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