Graeme Mardon, Ph.D.
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Positions
- James R. Davis Chair in Pathology and Immunology
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草榴社区入口
Houston, Texas United States
- Professor
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Molecular and Human Genetics
草榴社区入口
- Co-Director
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Graduate Program in Molecular and Human Genetics
草榴社区入口
- Professor
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Program in Developmental Biology
草榴社区入口
- Professor
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Neuroscience
草榴社区入口
- Professor
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Program in Integrative Molecular and Biomedical Sciences
草榴社区入口
- Professor
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Ophthalmology
草榴社区入口
Education
- BS from Haverford College
- 01/1980 - Haverford, PA United States
- PhD from Massachusetts Institute Of Technology
- 01/1990 - Cambridge, MA United States
- Post-Doctoral Fellowship at University Of California, Berkeley
- 01/1994 - Berkeley, CA United States
Honors & Awards
- Best Lecturer, 8-Stranded Beta-Barrel Jelly Roll Awards, 草榴社区入口
- 草榴社区入口 (01/2008)
- James M. Barr Award for Outstanding Retina Research Achievement
- 01/2006
- James M. Barr Award for Outstanding Retina Research Achievement
- 01/2002
- Marc Dresden Excellence in Graduate Education Award, 草榴社区入口
- 草榴社区入口 (01/2001)
- Brochstein Award for Outstanding Achievement in Retina Research
- 01/1999
Professional Interests
- Retinal cell fate determination, development, and function in Drosophila and vertebrates
Professional Statement
The primary goal of our research is to understand the molecular mechanisms of retinal development with the ultimate goal of improving our ability to prevent, diagnose and treat human retinal disease. To this end, we are using the fruit fly Drosophila melanogaster as a model system to identify and determine the function of conserved genes required for normal retinal development. In spite of substantial differences between vertebrate and insect retinal morphology, genetic mechanisms of retinal development have been conserved for more than 500 million years. Thus, study of the molecular and genetic pathways controlling Drosophila eye development has provided a valuable set of tools with which to decipher the development and function of the vertebrate retina.Our current research begins with the observation that the Epidermal Growth Factor Receptor (Egfr, a receptor tyrosine kinase) signaling pathway is both necessary and sufficient to trigger the differentiation of nearly all cell types in the Drosophila retina. This finding posed the question of how activation of a single pathway could trigger the differentiation of more than ten different cell types in the same tissue at the same time during development. Given the fundamental importance of Egfr signaling throughout higher eukaryotes in cancer, cell differentiation, proliferation and survival, it is of broad significance to unravel this conundrum. To this end, we have generated extensive single cell RNA-sequencing data on multiple stages of the developing and adult Drosophila eye, as well single cell chromatin accessibility data (ATAC-seq), and whole eye disc ChIP-seq for Pointed, the nuclear effector of Egfr signaling. Integration and mining of these data has led to multiple hypotheses of how the Egfr pathway is reiteratively used to regulate retinal cell fate determination which we are currently testing. In addition, these data have revealed many other new insights into Drosophila eye development with unprecedented resolution and provide a fertile starting point for myriad studies.
Websites
Selected Publications
- Roman D, Zhong H, Yaklichkin S, Chen R, Mardon G "." Exp Eye Res. 2018 Jul 25;176:219-226. Pubmed PMID:
- Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R. "." J Cell Biol. 2018 Aug 6;217(8):2851-2865. Pubmed PMID:
- Retshabile G, Mlotshwa BC, Williams L, Mwesigwa S, Mboowa G, Huang Z, Rustagi N, Swaminathan S, Katagirya E, Kyobe S, Wayengera M, Kisitu GP, Kateete DP, Wampande EM, Maplanka K, Kasvosve I, Pettitt ED, Matshaba M, Nsangi B, Marape M, et al "." Am J Hum Genet. 2018 May 3;102(5):731-743. Pubmed PMID:
- Jin M, Eblimit A, Pulikkathara M, Corr S, Chen R, Mardon G. "." FEBS J.. 2016 Aug;283(15):2754-66. Pubmed PMID:
- Jin M, Mardon G. "." Sci Rep.. 2016 Mar 16;6(23228) Pubmed PMID:
- Zhong H, Eblimit A, Moayedi Y, Boye SL, Chiodo VA, Chen Y, Li Y, Nichols RM, Hauswirth WW, Chen R, Mardon G "." Gene Ther. 2015 Aug;22:619-627. Pubmed PMID:
- Zhong H, Chen Y, Li Y, Chen R, Mardon G "." Sci Rep.. 2015 Jul;5:9731. Pubmed PMID:
- Jusiak B, Wang F, Karandikar UC, Kwak SJ, Wang H, Chen R, Mardon G "." Genom Data. 2014 Dec 1;2:153-5. Pubmed PMID:
- Yang Z, Zhong H, Chen J, Zhang X, Zhang H, Luo X, Xu S, Chen H, Lu D, Han Y, Li J, Fu L, Qi X, Peng Y, Xiang K, Lin Q, Guo Y, Li M, Cao X, Zhang Y, Liao S, Peng Y, Zhang L, Guo X, Dong S, Liang F, Wang J, Willden A, Seang Aun H, Serey B., et al "." Mol Biol Evol.. 2016 May;33(5):1177-87. Pubmed PMID:
- Pepple KL, Anderson AE, Frankfort BJ, Mardon G "." Genetics. 2007 Jan;175(1):125-41. Pubmed PMID:
- Gaul U, Mardon G, Rubin GM "." Cell. 1992 Mar 20;68(6):1007-19. Pubmed PMID:
- Davis RJ, Shen W, Sandler YI, Heanue TA, Mardon G "." Mech. Dev.. 2001 Apr;102(41276):169-79. Pubmed PMID:
- Loosli F, Mardon G, Wittbrodt J "." Mech. Dev.. 2002 Mar;112(41276):203-6. Pubmed PMID:
- Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Mardon G, Chen R. "." Exp Eye Res.. 2018 Jan;166:120-130. Pubmed PMID:
- Inoue Y, Mito T, Miyawaki K, Matsushima K, Shinmyo Y, Heanue TA, Mardon G, Ohuchi H, Noji S "." Mech. Dev.. 2002 May;113(2):141-8. Pubmed PMID:
- Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Moayedi Y, Mardon G, Chen R. "." Exp Eye Res.. 2018 Jun;171:119. Pubmed PMID:
- Davis RJ, Shen W, Sandler YI, Amoui M, Purcell P, Maas R, Ou CN, Vogel H, Beaudet AL, Mardon G "." Mol. Cell. Biol.. 2001 Mar;21(5):1484-90. Pubmed PMID:
- Heanue TA, Davis RJ, Rowitch DH, Kispert A, McMahon AP, Mardon G, Tabin CJ "." Mech. Dev.. 2002 Feb;111(41276):75-87. Pubmed PMID:
- Chen R, Amoui M, Zhang Z, Mardon G "." Cell. 1997 Dec 26;91(7):893-903. Pubmed PMID:
- Mardon G, Solomon NM, Rubin GM "." Development. 1994 Dec;120(12):3473-86. Pubmed PMID:
- Tavsanli BC, Pappu KS, Mehta SQ, Mardon G "." Genesis. 2001 Nov;31(3):130-6. Pubmed PMID:
- Karandikar UC, Jin M, Jusiak B, Kwak S, Chen R, Mardon G "." PLoS One. 2014 Jul 24;9(7):e102143. Pubmed PMID:
- Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, Zhou Y, Harding M, Bellen H, Mardon G "." Development. 2004 May;131(9):2183-94. Pubmed PMID:
- Davis RJ, Tavsanli BC, Dittrich C, Walldorf U, Mardon G "." Dev. Biol.. 2003 Jul 15;259(2):272-87. Pubmed PMID:
- Haase Gilbert E, Kwak SJ, Chen R, Mardon G "." PLoS ONE. 2013;8(4):e60908. Pubmed PMID:
- Pappu KS, Ostrin EJ, Middlebrooks BW, Sili BT, Chen R, Atkins MR, Gibbs R, Mardon G "." Development. 2005 Jun;132(12):2895-905. Pubmed PMID:
- Mardon G, Mosher R, Disteche CM, Nishioka Y, McLaren A, Page DC "." Science. 1989 Jan 6;243(4887):78-80. Pubmed PMID:
- Atkins M, Jiang Y, Sansores-Garcia L, Jusiak B, Halder G, Mardon G "." PLoS Genet.. 2013;9(8):e1003731. Pubmed PMID:
- Shen W, Mardon G "." Development. 1997 Jan;124(1):45-52. Pubmed PMID:
- Zhong H, Chen Y, Li Y, Chen R, Mardon G. "." Sci Rep. 2015 Jul 15;5:9731. Pubmed PMID:
- Wang H, Chen X, Dudinsky L, Patenia C, Chen Y, Li Y, Wei Y, Abboud EB, Al-Rajhi AA, Lewis RA, Lupski JR, Mardon G, Gibbs RA, Perkins BD, Chen R "." Mol. Vis.. 2011;17:3529-40. Pubmed PMID:
- Rayapureddi JP, Kattamuri C, Steinmetz BD, Frankfort BJ, Ostrin EJ, Mardon G, Hegde RS "." Nature. 2003 Nov 20;426(6964):295-8. Pubmed PMID:
- Jin M, Jusiak B, Bai Z, Mardon G "." PLoS ONE. 2013;8(3):e58818. Pubmed PMID:
- Mardon G, Varmus HE "." Cell. 1983 Mar;32(3):871-9. Pubmed PMID:
- Pappu KS, Mardon G "." Int. J. Dev. Biol.. 2004;48(41495):913-24. Pubmed PMID:
- Ostrin EJ, Li Y, Hoffman K, Liu J, Wang K, Zhang L, Mardon G, Chen R "." Genome Res.. 2006 Apr;16(4):466-76. Pubmed PMID:
- Jin M, Aibar S, Ge Z, Chen R, Aerts S, Mardon G. "." Dev Biol.. 2016 Jul 1;415(1):157-67. Pubmed PMID:
- Schaeffer E, Smith D, Mardon G, Quinn W, Zuker C "." Cell. 1989 May 5;57(3):403-12. Pubmed PMID:
- Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM "." Mol. Cell. Biol.. 1985 Apr;5(4):831-8. Pubmed PMID:
- Chen R, Mardon G "." Dev. Biol.. 2005 Jun 15;282(2):285-93. Pubmed PMID:
- Jusiak B, Abulimiti A, Haelterman N, Chen R, Mardon G "." PLoS ONE. 2012;7(12):e50776. Pubmed PMID:
- Pappu KS, Chen R, Middlebrooks BW, Woo C, Heberlein U, Mardon G "." Development. 2003 Jul;130(13):3053-62. Pubmed PMID:
- Davis RJ, Shen W, Heanue TA, Mardon G "." Dev. Genes Evol.. 1999 Sep;209(9):526-36. Pubmed PMID:
- Davis RJ, Harding M, Moayedi Y, Mardon G "." Genesis. 2008 Apr;46(4):205-13. Pubmed PMID:
- Davis RJ, Pesah YI, Harding M, Paylor R, Mardon G "." Genesis. 2006 Feb;44(2):84-92. Pubmed PMID:
- Mardon G, Luoh SW, Simpson EM, Gill G, Brown LG, Page DC "." Mol. Cell. Biol.. 1990 Feb;10(2):681-8. Pubmed PMID:
- Li Y, Wang H, Peng J, Gibbs RA, Lewis RA, Lupski JR, Mardon G, Chen R "." Invest. Ophthalmol. Vis. Sci.. 2009 Mar;50(3):1336-43. Pubmed PMID:
- Koenekoop RK, Wang H, Majewski J, Wang X, Lopez I, Ren H, Chen Y, Li Y, Fishman GA, Genead M, Schwartzentruber J, Solanki N, Traboulsi EI, Cheng J, Logan CV, McKibbin M, Hayward BE, Parry DA, Johnson CA, Nageeb M "." Nat. Genet.. 2012 Jul 29;44(9):1035-9. Pubmed PMID:
- Wang H, den Hollander AI, Moayedi Y, Abulimiti A, Li Y, Collin RW, Hoyng CB, Lopez I, Abboud EB, Al-Rajhi AA, Bray M, Lewis RA, Lupski JR, Mardon G, Koenekoop RK, Chen R "." Am. J. Hum. Genet.. 2009 Mar;84(3):380-7. Pubmed PMID:
- Eblimit A, Zaneveld SA, Liu W, Thomas K, Wang K, Li Y, Mardon G, Chen R. "." Exp Eye Res.. 2018 Aug;173:32-43. Pubmed PMID:
- Li Y, Jiang Y, Chen Y, Karandikar U, Hoffman K, Chattopadhyay A, Mardon G, Chen R. "." Dev Biol.. 2013 Sep 1;381(1):50-61. Pubmed PMID:
- Purcell P, Oliver G, Mardon G, Donner AL, Maas RL "." Gene Expr. Patterns. 2005 Dec;6(1):110-8. Pubmed PMID:
- Wiszniewski W, Lewis RA, Stockton DW, Peng J, Mardon G, Chen R, Lupski JR "." Hum. Genet.. 2011 Mar;129(3):319-27. Pubmed PMID:
- McClard CK, Kochukov MY, Herman I, Liu Z, Eblimit A, Moayedi Y, Ortiz-Guzman J, Colchado D, Pekarek B, Panneerselvam S, Mardon G, Arenkiel BR. "." J Neurosci.. 2018 Feb 7;38(6):1443-1461. Pubmed PMID:
- Schneider-G盲dicke A, Beer-Romero P, Brown LG, Mardon G, Luoh SW, Page DC "." Nature. 1989 Dec 7;342(6250):708-11. Pubmed PMID:
- Iyer J, Wang Q, Le T, Pizzo L, Gr枚nke S, Ambegaokar SS, Imai Y, Srivastava A, Trois铆 BL, Mardon G, Artero R, Jackson GR, Isaacs AM, Partridge L, Lu B, Kumar JP, Girirajan S. "." G3 (Bethesda). 2016 May 3;6(5):1427-37. Pubmed PMID:
- Frankfort BJ, Mardon G "." Development. 2002 Mar;129(6):1295-306. Pubmed PMID:
- Jusiak B, Karandikar UC, Kwak SJ, Wang F, Wang H, Chen R, Mardon G "." PLoS One. 2014 Feb 25;9(2):e89695. Pubmed PMID:
- Domingos PM, Brown S, Barrio R, Ratnakumar K, Frankfort BJ, Mardon G, Steller H, Mollereau B "." Dev. Biol.. 2004 Sep 1;273(1):121-33. Pubmed PMID:
- H3Africa Consortium, Rotimi C, Abayomi A, Abimiku A, Adabayeri VM, Adebamowo C, Adebiyi E, Ademola AD, Adeyemo A, Adu D, Affolabi D, Agongo G, Ajayi S, Akarolo-Anthony S, Akinyemi R, Akpalu A, Alberts M, Alonso Betancourt O, Alzohairy AM, Ameni G, et al "." Science. 2014 Jun 20;344(6190):1346-8. Pubmed PMID:
- Pappu KS, Mardon G. "." Int J Dev Biol. 2004;48(8-9):913-24. Pubmed PMID:
- Jiang Y, Scott KL, Kwak SJ, Chen R, Mardon G "." Oncogene. 2011 Jul 21;30(29):3248-60. Pubmed PMID:
- Frankfort BJ, Pepple KL, Mamlouk M, Rose MF, Mardon G "." Genesis. 2004 Apr;38(4):182-94. Pubmed PMID:
- Frankfort BJ, Mardon G "." Development. 2004 Feb;131(3):563-70. Pubmed PMID:
- Frankfort BJ, Nolo R, Zhang Z, Bellen H, Mardon G "." Neuron. 2001 Nov 8;32(3):403-14. Pubmed PMID:
- Simon MA, Carthew RW, Fortini ME, Gaul U, Mardon G, Rubin GM "." Cold Spring Harb. Symp. Quant. Biol.. 1992;57:375-80. Pubmed PMID:
- Chen R, Halder G, Zhang Z, Mardon G "." Development. 1999 Feb;126(5):935-43. Pubmed PMID:
- Atkins M, Mardon G "." Dev. Dyn.. 2009 Sep;238(9):2139-48. Pubmed PMID:
- Eblimit A, Nguyen TM, Chen Y, Esteve-Rudd J, Zhong H, Letteboer S, Van Reeuwijk J, Simons DL, Ding Q, Wu KM, Li Y, Van Beersum S, Moayedi Y, Xu H, Pickard P, Wang K, Gan L, Wu SM, Williams DS, Mardon G, Roepman R, Chen R. "." Hum Mol Genet. 2015 Mar 15;24(6):1584-601. Pubmed PMID:
- Tavsanli BC, Ostrin EJ, Burgess HK, Middlebrooks BW, Pham TA, Mardon G "." Dev. Biol.. 2004 Aug 1;272(1):231-47. Pubmed PMID:
- Heanue TA, Reshef R, Davis RJ, Mardon G, Oliver G, Tomarev S, Lassar AB, Tabin CJ "." Genes Dev.. 1999 Dec 15;13(24):3231-43. Pubmed PMID:
- Moayedi Y, Basch ML, Pacheco NL, Gao SS, Wang R, Harrison W, Xiao N, Oghalai JS, Overbeek PA, Mardon G, Groves AK. "." PLoS Genet. 2014 Jan;10(1):e1004055. Pubmed PMID:
- Mlotshwa BC, Mwesigwa S, Mboowa G, Williams L, Retshabile G, Kekitiinwa A, Wayengera M, Kyobe S, Brown CW, Hanchard NA, Mardon G, Joloba M, Anabwani G, Mpoloka SW. "." Genet Med. 2017 Jul;19(7):826-833. Pubmed PMID:
- Popov VM, Wu K, Zhou J, Powell MJ, Mardon G, Wang C, Pestell RG "." Trends Endocrinol. Metab.. 2010 Jan;21(1):41-9. Pubmed PMID:
- Chen K, Wu K, Jiao X, Wang L, Ju X, Wang M, Di Sante G, Xu S, Wang Q, Li K, Sun X, Xu C, Li Z, Casimiro MC, Ertel A, Addya S, McCue PA, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG. "." Cancer Res. 2015 May 15;75(10):1992-2004. Pubmed PMID:
- Anderson AE, Karandikar UC, Pepple KL, Chen Z, Bergmann A, Mardon G "." Development. 2011 May;138(10):1957-66. Pubmed PMID:
- Kaplan JM, Mardon G, Bishop JM, Varmus HE "." Mol. Cell. Biol.. 1988 Jun;8(6):2435-41. Pubmed PMID:
- "." ; Pubmed PMID:
- Martini SR, Roman G, Meuser S, Mardon G, Davis RL "." Development. 2000 Jun;127(12):2663-72. Pubmed PMID:
- Page DC, Mosher R, Simpson EM, Fisher EM, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG "." Cell. 1987 Dec 24;51(6):1091-104. Pubmed PMID:
- Mardon G, Page DC "." Cell. 1989 Mar 10;56(5):765-70. Pubmed PMID:
- Pepple KL, Atkins M, Venken K, Wellnitz K, Harding M, Frankfort B, Mardon G "." Development. 2008 Dec;135(24):4071-9. Pubmed PMID:
- Wang X, Wang H, Cao M, Li Z, Chen X, Patenia C, Gore A, Abboud EB, Al-Rajhi AA, A Lewis R, Lupski JR, Mardon G, Zhang K, Muzny D, Gibbs RA, Chen R "." Hum. Mutat.. 2011 Dec;32(12):1450-9. Pubmed PMID:
- Pesah Y, Burgess H, Middlebrooks B, Ronningen K, Prosser J, Tirunagaru V, Zysk J, Mardon G "." Genesis. 2005 Apr;41(4):154-9. Pubmed PMID:
- Yeung K, Wang F, Li Y, Wang K, Mardon G, Chen R "Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development.." Nucleic Acids Res.. 2018;46:11743-11758.
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