Positions
- Professor
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Orthopedic Surgery
草榴社区入口
Houston, TX US
- Professor
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Molecular and Human Genetics
草榴社区入口
- Associate Director
-
Center for Skeletal Medicine and Biology
草榴社区入口
- Adjunct Associate Professor
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Department of Medicine
Vanderbilt University
- Member
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Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Houston, Texas United States
Education
- Postdoctoral Fellowship at 草榴社区入口
- 01/2004 - Houston, Texas United States
- Molecular and Human Genetics
- PhD from Claude Bernard University
- 12/1999 - Lyon, France
Professional Interests
- Mechanisms of bone development, remodeling, repair and cancer cell metastasis
Professional Statement
Our research aims at understanding how the skeleton forms, grows, mineralizes, ages, repairs and communicates with other tissues in health and diseases.One main focus of the laboratory is on the etiology of the skeletal maladies observed in individuals with neurofibromatosis type I (NF1). We are particularly interested in the fracture non-union and dystrophic scoliosis observed in some of these patients. We use genetic and pharmacological strategies to identify both cells of origin and molecular abnormalities causing these orthopedic conditions, with the goal of designing and testing novel targeted therapeutic strategies to improve bone mass, bone strength and bone repair in children with NF1. These studies also provide critical insights into the role of neurofibromin, the RAS-GAP protein encoded by the NF1 gene, in endochondral bone formation, remodeling, repair and mineralization.
A second focus area of the laboratory is related to the interaction between the autonomic nervous system and bone cells. Our current emphasis is on determining the role of the endogenous sympathetic and parasympathetic nervous systems in the regulation of bone homeostasis, and on addressing the biological and clinical relevance of these preclinical findings. This leads us to study the role of the norepinephrine transporter and conditions including bone aging, depression and Alzheimer鈥檚 disease and their impact on bone remodeling.
A third active line of research in the laboratory revolves around the biology of chondrocytes, the cells of cartilaginous tissues that allow bone elongation during the development and protection of joint articular surfaces in adults. Through our focus on the transcription factor TonEBP/Nfat5, we investigate how chondrocytes survive and function in their hyperosmotic, avascular and low nutrient environment.
Websites
Selected Publications
- Couasnay G, Madel MB, Lim J, Lee B, Elefteriou F "Sites of Cre-recombinase activity in mouse lines targeting skeletal cells.." J Bone Miner Res. 2021;
- Ma Y, Gross AM, Dombi E, (...), Widemann BC, Rios JJ, Elefteriou F "." Genet Med.. 2020;22:1786-1793. Pubmed PMID:
- Ma Y, Elefteriou F "." J Bone Miner Res. 2020;35:1562-1571. Pubmed PMID:
- Zhu Y, Ma Y, Elefteriou F "." Bone Rep.. 2018;9:188-198. Pubmed PMID:
- Elefteriou F "." Physiol Rev. 2018;98:1083-1112. Pubmed PMID:
- Mulcrone PL, Campbell JP, Cl茅ment-Demange L, Anbinder AL, Merkel AR, Brekken RA, Sterling JA, Elefteriou F "." J Bone Miner Res.. 2017;32:1442-1454. Pubmed PMID:
- Vignaux G, Ndong JD, Perrien DS, Elefteriou F "." J Bone Miner Res. 2015 Jun;30(6):1103-11. Pubmed PMID:
- Karolak MR, Yang X, Elefteriou F "." Hum Mol Genet. 2015 May 1;24(9):2552-64. Pubmed PMID:
- de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F "." Nat Med. 2014 Aug;20(8):904-10. Pubmed PMID:
- Ma Y, Krueger JJ, Redmon SN, Uppuganti S, Nyman JS, Hahn MK, Elefteriou F "." J Biol Chem. 2013 Oct 18;288(42):30105-13. Pubmed PMID:
- Ono K, Karolak MR, Ndong Jde L, Wang W, Yang X, Elefteriou F "." Hum Mol Genet. 2013 Aug 1;22(15):3048-62. Pubmed PMID:
- Stevenson DA, Little D, Armstrong L, Crawford AH, Eastwood D, Friedman JM, Greggi T, Gutierrez G, Hunter-Schaedle K, Kendler DL, Kolanczyk M, Monsell F, Oetgen M, Richards BS, Schindeler A, Schorry EK, Wilkes D, Viskochil DH, Yang FC, Elefteriou F "." J Pediatr Orthop. 2013 Apr;33(3):269-75. Pubmed PMID:
- Campbell JP, Karolak MR, Ma Y, Perrien DS, Masood-Campbell SK, Penner NL, Munoz SA, Zijlstra A, Yang X, Sterling JA, Elefteriou F "." PLoS Biol. 2012 Jul;10(7):e1001363. Pubmed PMID:
- Wang W, Nyman JS, Ono K, Stevenson DA, Yang X, Elefteriou F "." Hum Mol Genet. 2011 Oct 15;20(20):3910-24. Pubmed PMID:
- Patel MS, Elefteriou F "." Calcif Tissue Int. 2007 May;80(5):337-47. Pubmed PMID:
- Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G "." Nature. 2005 Mar 24;434(7032):514-20. Pubmed PMID:
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