Positions
- Associate Professor
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Pathology and Immunology
草榴社区入口
- Associate Professor
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Molecular & Cellular Biology
草榴社区入口
- Faculty Member
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Cancer & Cell Biology Graduate Program and Development, Disease Models & Therapeutics Graduate Program
草榴社区入口
- Faculty Senator
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草榴社区入口
- Member
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Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Addresses
- One Baylor Plaza (Office)
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Office: BCM-T221
Houston, TX 77030-3411
United States
- One Baylor Plaza (Lab)
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Lab: BCM-T207
Houston, TX 77030-3411
United States
Education
- PhD from Institute of Biophysics, Chinese Academy of Sciences
- Beijing, China
- Postdoctoral Training at 草榴社区入口
- Houston, Texas United States
Honors & Awards
- Idea Development Award
- DOD, Prostate Cancer Research Program, 2023
- Research Project Grant (R01)
- NCI/NIH, 2023
- Individual Investigator Research Award
- Cancer Prevention & Research Institute of Texas, 2020
- Breakthrough Award Funding Level 2
- DOD, Breast Cancer Research Program, 2017
- Collaborative Research Project with AHMMRF
- Adrienne Helis Malvin Medical Research Foundation, 2015
- Idea Development Award
- DOD, Prostate Cancer Research Program, 2013
- Individual Investigator Research Award
- Cancer Prevention & Research Institute of Texas, 2013
- Idea Development Award
- DOD, Prostate Cancer Research Program, 2013
- New Investigator Award
- DOD, Prostate Cancer Research Program, 2009
- Concept Award
- DOD, Breast Cancer Research Program, 2009
- Exploration-Hypothesis Development Award
- DOD, Prostate Cancer Research Program, 2007
Professional Interests
- MAPK4 biology in human cancers
- Signaling Pathways Regulating Prostate Cancer
- Therapy-resistance of Human Cancers
- Mouse Models for Human Cancers
- Tumor Microenvironment
Professional Statement
Focusing on cancer research, educating researchers, making discoveries, and turning discoveries into effective therapies for cancer patients.Websites
Selected Publications
- Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F "." J Clin Invest. 2019;129(3):1015-29. Pubmed PMID:
- Shen T, Wang W, Zhou W, Coleman I, Cai Q, Dong B, Ittmann M, Creighton CJ, Bian Y, Meng Y, Rowley DR, Nelson PS, Moore DD, Yang F "." J Clin Invest. 2021;131(4):e135465. Pubmed PMID:
- Cai Q, Zhou W, Wang W, Dong B, Han D, Shen T, Creighton CJ, Moore DD, Yang F "." Sci Adv. 2021;7(46):eabi6439. Pubmed PMID:
- Shen T, Dong B, Meng Y, Moore DD, Yang F "." Proc Natl Acad Sci U S A. 2022;119(43):e2205350119. Pubmed PMID:
- Wang W, Han D, Cai Q, Shen T, Dong B, Lewis MT, Wang R, Meng Y, Zhou W, Yi P, Creighton CJ, Moore DD, Yang F. "." Nat Commun. 2022;13(1):245. Pubmed PMID:
- Han D, Wang W, Jeon JH, Shen T, Huang X, Yi P, Dong B, Yang F "." PLoS Biol. 2023;21(8):e3002227. Pubmed PMID:
Projects
- MAPK4 biology in human cancers
- MAPK4 is an atypical MAPK that was not well studied. MAPK4 biology in human diseases, including cancers, was largely unknown. We discovered that MAPK4 activates Akt/mTOR and several other key signal pathways to promote cancer initiation, progression, and therapy-resistance. We are now pioneering the research on MAPK4 biology in human cancers and are carrying out in-depth studies to reveal the molecular mechanisms underlying MAPK4 regulation of human cancers.
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