David Lonard, Ph.D.
Picture
David Lonard, Ph.D.
Professor
Positions
- Professor
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Mol & Cell Biology-Mol.Regulation
草榴社区入口
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Houston, Texas United States
Addresses
- BCM-Michael DeBakey Center (Office)
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Room: BCMM-M809
Houston, TX 77030
United States
- BCM-Michael DeBakey Center (Lab)
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Room: BCMM-M809
Houston, TX 77030
United States
Education
- Advanced Training from Baylor College Of Medicine
- 01/2002 - Houston, TX United States
- Ph.D. from Texas A&M University
- 01/1996 - College Station, TX United States
- B.S. from Texas A&M University
- 01/1992 - College Station, TX United States
Certifications
- Associate Professor
- 草榴社区入口
Professional Interests
- Research interests
Professional Statement
My laboratory is interested in delineating the molecular mechanisms that link proteasome-mediated protein degradation to nuclear receptor mediated gene expression and coactivator function. As a postdoctoral fellow in Dr. Bert O鈥橫alley鈥檚 group, I was able to establish that the ubiquitin-proteasome pathway is required for efficient transcription mediated through the estrogen receptor and other nuclear receptors. These studies established that the proteasome has complex and dynamic effects on the function of steroid receptor coactivator (SRC) family members. My current interests are focused on taking advantage of these basic findings to design high throughput small molecule inhibitors (SMIs) to target these coactivators. Given the pleiotropic roles of SRC family coactivators in cancer, energy metabolism and reproduction, we plan to develop novel coactivator-targeting compounds as therapeutic agents to treat or control these broad pathological and physiological states. Through high throughput screening of small molecule compound libraries, we have identified agents that are able to inhibit SRC function.Websites
Selected Publications
- Li X, Lonard DM, O'Malley BW "." Mech. Ageing Dev..;125(41558):669-78. Pubmed PMID:
- He B, Feng Q, Mukherjee A, Lonard DM, DeMayo FJ, Katzenellenbogen BS, Lydon JP, O'Malley BW "." Mol. Endocrinol.. 2008 Feb;22(2):344-60. Pubmed PMID:
- Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW "." Mol. Cell. 2008 Feb 29;29(4):465-76. Pubmed PMID:
- Lonard DM, O'Malley BW "." Prog Mol Biol Transl Sci. 2009;87:117-35. Pubmed PMID:
- Yu G, Zhao Y, He J, Lonard DM, Mao CA, Wang G, Li M, Li X "." J Mol Cell Biol. 2010 Aug;2(4):192-8. Pubmed PMID:
- Long W, Foulds CE, Qin J, Liu J, Ding C, Lonard DM, Solis LM, Wistuba II, Qin J, Tsai SY, Tsai MJ, O'Malley BW "." J. Clin. Invest.. 2012 May 1;122(5):1869-80. Pubmed PMID:
- Lonard DM, O'Malley BW "." Trends Biochem. Sci.. 2005 Mar;30(3):126-32. Pubmed PMID:
- Lonard DM, O'Malley BW "." Nature. 2008 Apr 24;452(7190):946-7. Pubmed PMID:
- Dennis AP, Lonard DM, Nawaz Z, O'Malley BW "." J. Steroid Biochem. Mol. Biol.. 2005 Mar;94(4):337-46. Pubmed PMID:
- Lonard DM, Kumar R, O'Malley BW "." Mol. Endocrinol.. 2010 Feb;24(2):279-85. Pubmed PMID:
- Luo Z, Xu X, Gu P, Lonard D, Gunaratne PH, Cooney AJ, Azencott R "." PLoS ONE. 2011;6(10):e23263. Pubmed PMID:
- Stanisic V, Lonard DM, O'Malley BW "." Prog. Brain Res.. 2010;181:153-76. Pubmed PMID:
- Lonard DM, Smith CL "." Steroids. 2002 Jan;67(1):15-24. Pubmed PMID:
- Han SJ, Lonard DM, O'Malley BW "." Trends Endocrinol. Metab.. 2009 Jan;20(1):41501. Pubmed PMID:
- Lonard DM, Lanz RB, O'Malley BW "." Endocr. Rev.. 2007 Aug;28(5):575-87. Pubmed PMID:
- Lonard DM, O'malley BW "." Mol. Cell. 2007 Sep 7;27(5):691-700. Pubmed PMID:
- Lonard DM, O'Malley BW "." Nat Rev Endocrinol. 2012 Oct;8(10):598-604. Pubmed PMID:
- Stanisic V, Malovannaya A, Qin J, Lonard DM, O'Malley BW "." J. Biol. Chem.. 2009 Jun 12;284(24):16135-45. Pubmed PMID:
- Geng C, He B, Xu L, Barbieri CE, Eedunuri VK, Chew SA, Zimmermann M, Bond R, Shou J, Li C, Blattner M, Lonard DM, Demichelis F, Coarfa C, Rubin MA, Zhou P, O'Malley BW, Mitsiades N "." Proc. Natl. Acad. Sci. U.S.A.. 2013 Apr 23;110(17):6997-7002. Pubmed PMID:
- Nawaz Z, Lonard DM, Dennis AP, Smith CL, O'Malley BW "." Proc. Natl. Acad. Sci. U.S.A.. 1999 Mar 2;96(5):1858-62. Pubmed PMID:
- Cavarretta IT, Mukopadhyay R, Lonard DM, Cowsert LM, Bennett CF, O'Malley BW, Smith CL "." Mol. Endocrinol.. 2002 Feb;16(2):253-70. Pubmed PMID:
- Liu J, Yu G, Zhao Y, Zhao D, Wang Y, Wang L, Liu J, Li L, Zeng Y, Dang Y, Wang C, Gao G, Long W, Lonard DM, Qiao S, Tsai MJ, Zhang B, Luo H, Li X "." J. Cell. Sci.. 2010 Dec 1;123:4076-84. Pubmed PMID:
- Lonard DM, Tsai SY, O'Malley BW "." Mol. Cell. Biol.. 2004 Jan;24(1):14-24. Pubmed PMID:
- Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, O'Malley BW "." Mol. Endocrinol.. 2011 Dec;25(12):2041-53. Pubmed PMID:
- Yan F, Gao X, Lonard DM, Nawaz Z "." Mol. Endocrinol.. 2003 Jul;17(7):1315-31. Pubmed PMID:
- Wu RC, Feng Q, Lonard DM, O'Malley BW "." Cell. 2007 Jun 15;129(6):1125-40. Pubmed PMID:
- Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW "." Genes Dev.. 2013 Feb 1;27(3):274-87. Pubmed PMID:
- Lonard DM, O'Malley BW "." 2008;1(13):pe16. Pubmed PMID:
- Lonard DM, Nawaz Z, Smith CL, O'Malley BW "." Mol. Cell. 2000 Jun;5(6):939-48. Pubmed PMID:
- Nawaz Z, Lonard DM, Smith CL, Lev-Lehman E, Tsai SY, Tsai MJ, O'Malley BW "." Mol. Cell. Biol.. 1999 Feb;19(2):1182-9. Pubmed PMID:
- Lonard DM, O'Malley BW "." Cell. 2006 May 5;125(3):411-4. Pubmed PMID:
- Li X, Lonard DM, Jung SY, Malovannaya A, Feng Q, Qin J, Tsai SY, Tsai MJ, O'Malley BW "." Cell. 2006 Jan 27;124(2):381-92. Pubmed PMID:
- Li C, Ao J, Fu J, Lee DF, Xu J, Lonard D, O'Malley BW "." Oncogene. 2011 Oct 20;30(42):4350-64. Pubmed PMID:
- Li X, Amazit L, Long W, Lonard DM, Monaco JJ, O'Malley BW "." Mol. Cell. 2007 Jun 22;26(6):831-42. Pubmed PMID:
Funding
- Small molecule SRC-2 antagonists as regulators of Sertoli cell function and male fertility - #5U01HD076596
- $219,100.00 (08/24/2012 - 06/30/2017) Grant funding from NIH
- The goal of this study is to identify and develop small molecule antagonist capable of inhibiting SRC-2 for their use as male contraceptive agents
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