Positions
- Professor
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Molecular & Human Genetics
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Houston, TX US
- Joint Professor
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Department of Statistics
Rice University
Houston, Texas United States
- Director
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D2K Laboratory
Rice University
- Investigator
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Jan and Dan Duncan Neurological Research Institute
- Faculty Member
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Stem Cells and Regenerative Medicine (STaR) Center
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- Faculty Member
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Graduate Program in Quantitative & Computational Biosciences
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Education
- BS from Duke University
- 01/1995 - Durham, NC United States
- Mathematics
- PhD from Rice University
- 01/2001 - Houston, TX United States
- Statistics
Professional Interests
- Statistics, Genomics, Systems Biology, Bioinformatics
Professional Statement
Chad Shaw is trained as a mathematical statistician, and he has worked in statistical genomics and bioinformatics for approximately 20 years. He is currently a professor of molecular and human genetics at Baylor and a joint professor of statistics at Rice University. He is also the Director of the D2K Laboratory at Rice University.He has experience in next-generation sequencing, variant analysis, multi-omic data integration, gene expression profiling and variant functionalization. He also has expertise in copy-number analysis and has worked in the area of mechanistic studies of structural variation, with a focus on the role of repetitive elements in new mutations.
He led the development and analysis of an applied probabilistic model for the transmission of new mutations in the context of human genetic disease, which led to the elucidation of the dependency of recurrence risk on parent of origin, parental somatic mosaicism and paternal age. This fundamental contribution to human genetics was featured in many reviews and in the New York Times as a lay press article.
He has been an author on approximately 200 peer-reviewed publications, and his work has been cited approximately 17,000 times. He has trained 5 Ph.D. students in his own laboratory and over 10 students as a thesis committee member. He serves as chairman of the qualifying exam committee for the Quantitative and Computational Biosciences program. His students have performed methodologic research in high dimensional sparse regression, statistical methods for high throughput NGS screens approaches to modifiers of Mendelian disease, eQTL analyses and software tools for variant prioritization in rare disease diagnostics.
Websites
Selected Publications
- Ghazi AR, Kong X, Chen ES, Edelstein LC, Shaw CA "." PLoS Comput Biol.. 2020;16:e1007504. Pubmed PMID:
- Yuan, B., Wang, L., Liu, P. et al "CNVs cause autosomal recessive genetic diseases with or without involvement of SNV/indels.." Genet Med.. 2020;22:1633鈥1641.
- Beck CR, Carvalho CMB, Akdemir ZC, Sedlazeck FJ, Song X, (...), Shaw CA, Gibbs RA, Hastings PJ, Lupski JR "Megabase Length Hypermutation Accompanies Human Structural Variation at 17p11.2.." Cell. 2019;176:1310-1324.e10..
- Cao Y, Tokita MJ, Chen ES, et al. "." Genome Med. 2019;11:12. Pubmed PMID:
- Liu P, Meng L, Normand EA, Xia F, Song X, et al. "." N Engl J Med. 2019;380:2478-2480. Pubmed PMID:
- Yuan B, Neira J, Pehlivan D, Santiago-Sim T, Song X, et al. "." Genet Med. 2019;21:663-675. Pubmed PMID:
- Posey JE, Harel T, Liu P, Rosenfeld JA, James RA, et al. "." N Engl J Med.. 2017;376:21-31. Pubmed PMID:
- Liu P, Yuan B, Carvalho CM, Wuster A, Walter K, et al. "." Cell. 2017;168:830. Pubmed PMID:
- Breman AM, Chow JC, U'Ren L, et al. "." Prenat Diagn.. 2016;36:1009鈥1019. Pubmed PMID:
- K酶lvraa S, Singh R, Normand EA, Qdaisat S, Van denVeyver IB, Jackson L, Hatt L, Schelde P, Uldbjerg N, Vestergaard EM, Zhao L, Chen R, Shaw CA, Breman AM, Beaudet AL. "." Prenat Diagn.. 2016; Pubmed PMID:
- Normand, E., Qdaisat, S., Bi, W., Shaw, C., Van den Veyver, I., Beaudet, A., Breman, A. "." Prenat Diagn.. 2016;36:823-30. Pubmed PMID:
- Simon LM, Chen ES, Edelstein LC, Kong X, Bhatlekar S, Rigoutsos I, Bray PF, Shaw CA "." Am J Hum Genet. 2016;98:883-97. Pubmed PMID:
- Hsu TY, Simon LM, Neill NJ; Marcotte R, Sayad A, et al. "." Nature. 2015;525:384-8. Pubmed PMID:
- Startek M, Szafranski P, Gambin T, Campbell IM, Hixson P, Shaw CA, Stankiewicz P, Gambin A. "." Nucleic Acids Res.. 2015;43:2188-98. Pubmed PMID:
- James RA, Campbell IM, Chen ES, Boone PM, Rao MA, Bainbridge MN, Lupski JR, Yang Y, Eng CM, Posey JE, Shaw CA. "." Nucleic Acids Res.. 2015;43:2188-98. Pubmed PMID:
- Campbell, Stewart JR, James RA, Lupski JR, Stankiewicz P, Olofsson LP, Shaw CA "." 2014 Oct 2;95(4):345-359. Pubmed PMID:
- Boone PM, Yuan B, Campbell IM, Scull JC, Withers MA, et al. "." Am J Hum Genet. 2014;95:143-61. Pubmed PMID:
- Campbell IM, Yuan B, Robberecht C, Pfundt R, Szafranski P, 鈥, Cheung SW, Shaw CA, Vissers LE, Vermeesch JR, Lupski JR, Stankiewicz P. "." Am J Hum Genet. 2014;95:173-82. Pubmed PMID:
- Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA "." PLoS Biol.. 2004 Oct;2(10):e301. Pubmed PMID:
- Dittwald P, Gambin T, Szafranski P, Li J, Amato S, Divon MY, Kang SH, Breman A, Lalani SR, Bacino CA, Bi W, Milosavljevic A, Beaudet AL, Patel A, Shaw CA, Lupski JR, Gambin A, Cheung SW, Stankiewicz P. "." Genome Res.. 2013;23:1395-409. Pubmed PMID:
- Breman A, Pursley AN, Hixson P, Bi W, Ward P, Bacino CA, Shaw C, Lupski JR, Beaudet A, Patel A, Cheung SW, Van den Veyver I "." Prenat. Diagn.. 2012 Apr;32(4):351-61. Pubmed PMID:
- Ramocki MB, Bartnik M, Szafranski P, Kolodziejska KE, Xia Z, Bravo J, Miller GS, Rodriguez DL, Williams CA, Bader PI, Szczepanik E, Mazurczak T, Antczak-Marach D, Coldwell JG, Akman CI, McAlmon K, Cohen MP, McGrath J, Roeder E, Mueller J, Kang SH, Bacino "." Am. J. Hum. Genet.. 2010 Dec 10;87(6):857-65. Pubmed PMID:
- Boone PM, Bacino CA, Shaw CA, Eng PA, Hixson PM, Pursley AN, Kang SH, Yang Y, Wiszniewska J, Nowakowska BA, del Gaudio D, Xia Z, Simpson-Patel G, Immken LL, Gibson JB, Tsai AC, Bowers JA, Reimschisel TE, Schaaf CP, Potocki L, Scaglia F, Gambin T, Sykulski "." Hum. Mutat.. 2010 Dec;31(12):1326-42. Pubmed PMID:
- Carvalho CM, Zhang F, Liu P, Patel A, Sahoo T, Bacino CA, Shaw C, Peacock S, Pursley A, Tavyev YJ, Ramocki MB, Nawara M, Obersztyn E, Vianna-Morgante AM, Stankiewicz P, Zoghbi HY, Cheung SW, Lupski JR "." Hum. Mol. Genet.. 2009 Jun 15;18(12):2188-203. Pubmed PMID:
- Van den Veyver IB, Patel A, Shaw CA, Pursley AN, Kang SH, Simovich MJ, Ward PA, Darilek S, Johnson A, Neill SE, Bi W, White LD, Eng CM, Lupski JR, Cheung SW, Beaudet AL "." Prenat. Diagn.. 2009 Jan;29(1):29-39. Pubmed PMID:
- Probst FJ, Roeder ER, Enciso VB, Ou Z, Cooper ML, Eng P, Li J, Gu Y, Stratton RF, Chinault AC, Shaw CA, Sutton VR, Cheung SW, Nelson DL "." Am. J. Med. Genet. A. 2007 Jun 15;143(12):1358-65. Pubmed PMID:
- Sahoo T, Bacino CA, German JR, Shaw CA, Bird LM, Kimonis V, Anselm I, Waisbren S, Beaudet AL, Peters SU "." Eur. J. Hum. Genet.. 2007 Sep;15(9):943-9. Pubmed PMID:
- Lu X, Shaw CA, Patel A, Li J, Cooper ML, Wells WR, Sullivan CM, Sahoo T, Yatsenko SA, Bacino CA, Stankiewicz P, Ou Z, Chinault AC, Beaudet AL, Lupski JR, Cheung SW, Ward PA "." PLoS ONE. 2007;2(3):e327. Pubmed PMID:
- Cheung SW, Shaw CA, Scott DA, Patel A, Sahoo T, Bacino CA, Pursley A, Li J, Erickson R, Gropman AL, Miller DT, Seashore MR, Summers AM, Stankiewicz P, Chinault AC, Lupski JR, Beaudet AL, Sutton VR "." Am. J. Med. Genet. A. 2007 Aug 1;143(15):1679-86. Pubmed PMID:
- Sahoo T, Cheung SW, Ward P, Darilek S, Patel A, del Gaudio D, Kang SH, Lalani SR, Li J, McAdoo S, Burke A, Shaw CA, Stankiewicz P, Chinault AC, Van den Veyver IB, Roa BB, Beaudet AL, Eng CM "." Genet. Med.. 2006 Nov;8(11):719-27. Pubmed PMID:
- Lim J, Hao T, Shaw C, Patel AJ, Szab贸 G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barab谩si AL, Vidal M, Zoghbi HY "." Cell. 2006 May 19;125(4):801-14. Pubmed PMID:
- Young A, Whitehouse N, Cho J, Shaw C "." Bioinformatics. 2005 Jan 15;21(2):275-6. Pubmed PMID:
- Shaw CJ, Shaw CA, Yu W, Stankiewicz P, White LD, Beaudet AL, Lupski JR "." J Med Genet.. 2004;41(2):113-9. Pubmed PMID:
- Cheung SW, Shaw CA, Yu W, Li J, Ou Z, Patel A, Yatsenko SA, Cooper ML, Furman P, Stankiewicz P, Stankiewicz P, Lupski JR, Chinault AC, Beaudet AL "." Genet. Med..;7(6):422-32. Pubmed PMID:
Memberships
- American Society of Human Genetics
- member
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