Positions
- Professor
-
Medicine
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- Co-Director of Cancer Bioinformatics
-
Dan L Duncan Comprehensive Cancer Center
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- Affiliated Faculty Member
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Human Genome Sequencing Center
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Education
- PhD from University Of Michigan
- 06/2006 - Ann Arbor, Michigan United States
- Bioinformatics
- BS from University of Idaho
- 05/1996 - Moscow, Idaho United States
- Physics
Professional Interests
- Understanding the molecular basis of cancer through genomics and proteomics
- Integrative analysis of diverse molecular data types
- Mining public genomic databases
- Noncoding somatic DNA alterations
Professional Statement
My focus is on bioinformatics analysis of molecular profiling data, which may include mRNA expression, microRNA expression, protein expression, DNA methylation, or DNA copy number. Fundamentally, my work seeks to obtain meaningful information from large-scale molecular datasets regarding questions relevant to improving cancer diagnosis and treatment. This often involves integration of molecular profiling results from different sources. Among other things, I have participated extensively in The Cancer Genome Atlas (TCGA), Pan-Cancer Analysis of Whole Genomes (PCAWG), and Children's Brain Tumor Network (CBTN) consortiums, multi-institutional efforts to systematically characterize the genomic changes that occur in cancer.Websites
Selected Publications
- Davis CF, Ricketts CJ, Wang M, Yang L, ..., Rathmell WK, Creighton CJ "." Cancer Cell. 2014;26(3):319-30. Pubmed PMID:
- Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, …, Park PJ, Kucherlapati R, Scott KL, Mills GB, Kwiatkowski DJ, Creighton CJ "." Cancer Cell. 2017 May 8;31(6):820-832. Pubmed PMID:
- Chen F, Zhang Y, Sxenbabaoglu Y, Ciriello G, Yang L, Reznik E, …, Choueiri TK, Hsieh JJ, Akbani R, Mills GB, Hakimi AA, Wheeler DA, Creighton CJ "." Cell Rep. 2016 Mar 2;14(10):2476-89. Pubmed PMID:
- Zhang Y, Yang L, Kucherlapati M, Hadjipanayis A, Pantazi A, Bristow CA, Lee EA, Mahadeshwar HS, Tang J, Zhang J, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Park PJ, Kucherlapati R, Creighton CJ "." Genome Biol. 2019;20(1):209. Pubmed PMID:
- Chen F, Chandrashekar DS, Varambally S, Creighton CJ "." Nat Commun. 2019;10(1):5679. Pubmed PMID:
- Zhang Y, Yang L, Kucherlapati M, ..., Creighton CJ "." Cell Rep. 2018;24(2):515-527. Pubmed PMID:
- Zhang Y, Chen F, ...,PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Creighton CJ "." Nat Commun. 2020;11(1):736. Pubmed PMID:
- Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski DJ, Ittmann M, Creighton CJ "." Clin Cancer Res. 2018;24(9):2182-2193. Pubmed PMID:
- Tan X, Banerjee P, ..., Creighton CJ*, Glenn JS*, Kurie JM* "." Sci Transl Med. 2020;10(1):5679. Pubmed PMID:
- John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ*, Deneen B* "." Nat Neurosci. 2017;20(3):396-405. Pubmed PMID:
- Zhang Y, Chen F, Donehower LA, Scheurer ME, Creighton CJ "." Nat Commun. 2021;12(1):937. Pubmed PMID:
- Zhang Y, Chen F, Chandrashekar DS, Varambally S, Creighton CJ "." Nat Commun. 2022;13(1):2669. Pubmed PMID:
- Zhang Y, Chen F, Creighton CJ "." Cell Rep Med. 2023 Feb 1; Pubmed PMID:
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