Positions
- Professor
-
Verna and Marrs McLean Department of Biochemistry and Molecular Biology
草榴社区入口
Houston, Texas United States
Primary Appointment
- Alvin Romansky Chair in Biochemistry
-
Verna and Marrs McLean Department of Biochemistry and Molecular Biology
草榴社区入口
Houston, Texas United States
- Director
-
Graduate Program in Chemical, Physical & Structural Biology
草榴社区入口
- Professor
-
Molecular Virology and Microbiology
草榴社区入口
Houston, Texas United States
Secondary Appointment
- Member
-
Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Houston, Texas United States
Addresses
- BCM-Alkek Graduate School (Office)
-
Room: BCMN-N410
Houston, TX 77030
United States
Education
- Postdoctoral Fellowship at University of Arizona
- 01/1988 - Tucson, Arizona United States
- Postdoctoral Training at Indian Institute of Science
- 01/1984 - Bangalore, Karnataka India
- PhD from Indian Institute of Science
- 01/1981 - Bangalore, Karnataka India
- MSc from Indian Institute of Technology
- 01/1974 - Bombay, Maharashtra India
- BSc from Bangalore University
- 01/1972 - Bangalore, Karnataka India
Honors & Awards
- Fellow of the American Academy of Microbiology
- Fellow of the American Academy of Microbiology
- American Academy of Microbiology (08/2015)
- Ruth McLean Bowman Bowers Excellence in Research Award
- 草榴社区入口 (01/2013)
- Ruth McLean Bowman Bowers Excellence in Research Award
- 草榴社区入口 (01/2010)
- Alvin Romansky Professor and Chair of Biochemistry
- 草榴社区入口 (07/2008)
- Indo-US Professorship for the American Society of Microbiology
- American Society of Microbiology (01/2004 - 12/2005)
- NIH MERIT award
- NIH MERIT award (01/2003)
- Indian National Science Academy Medal for Young Scientists
- Indian National Science Academy Medal for Young Scientists (01/1983)
- NIAID MERIT Award
- The MERIT award is given to investigators who have demonstrated superior competence and outstanding productivity in their research
- National Institute of Allergy and Infectious Diseases (09/2013)
Professional Interests
- Protein Structure-Function and Protein Folding
- Virology, biochemistry, immunology and cell biology of viral and microbial pathogen
- Glycobiology of pathogen-host interactions
- Host-pathogen coevolution
- Cellular Antiviral Responses
- Antiviral Drug Discovery/Design, and Vaccine Strategies
- Quantitative and Computational Biosciences
- Viral Pathogens
Professional Statement
Main focus of our research program, largely funded by NIH and Welch foundation, is to understand structure-function relationships in medically important viruses with a clear emphasis on using this knowledge to develop/design effective antiviral drugs. Our structure-function studies are mainly focused on three human pathogens: Rotaviruses, which are major pathogens of infantile gastroenteritis; Noroviruses in Caliciviridae (NIAD priority B biodefense pathogen), which cause epidemic diarrhea in humans; and influenza viruses (NIAD priority C biodefense pathogen), which cause seasonal and pandemic flu.Our approach is to use a variety of structural techniques including cryo-electron microscopy and X-ray crystallography along with various biochemical and cell biology techniques to elucidate structure-function relationships in these human pathogens. In addition to understanding the structural basis for the capsid-related activities such as how viruses gain entry into host cells, how they interact with receptors, how they evade immune surveillance, and how they disassemble, we also focus on understanding the molecular processes by which these viruses successfully replicate once inside the host cells. The latter processes, which include genome transcription, viral protein synthesis, genome replication and encapsidation, and finally assembly of the new virions, are controlled by exquisite interplay between virus-encoded non-structural proteins some of which have fascinating enzymatic activities. Although these processes vary from one virus to another they are conserved between various strains in each virus family, thus making them suitable targets for designing and developing effective antiviral strategies.
One of the fascinating aspects of virus replication is how these viruses counteract antiviral response mounted by the host cells, for example, interferon response. Each virus appears to specially designate a viral protein to antagonize the host immune response. In rotavirus it is the non-structural protein NSP1 and in influenza virus it is NS1. During this process, these viral proteins target critical cellular pathways by interacting with various cellular proteins. Thus our research on understanding the molecular basis of such a process provides an excellent opportunity to interface with cell biology.
Websites
Selected Publications
- Lawton JA, Estes MK, Prasad BV "." Nat. Struct. Biol.. 1997 Feb;4(2):118-21. Pubmed PMID:
- Prasad BV, Rothnagel R, Zeng CQ, Jakana J, Lawton JA, Chiu W, Estes MK "." Nature. 1996 Aug 1;382(6590):471-3. Pubmed PMID:
- Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK "." Science. 1999 Oct 8;286(5438):287-90. Pubmed PMID:
- Bornholdt ZA, Prasad BV "." Nature. 2008 Dec 18;456(7224):985-8. Pubmed PMID:
- Shanker S, Choi JM, Sankaran B, Atmar RL, Estes MK, Prasad BV "." J. Virol.. 2011 Sep;85(17):8635-45. Pubmed PMID:
- Shaw AL, Rothnagel R, Chen D, Ramig RF, Chiu W, Prasad BV "." Cell. 1993 Aug 27;74(4):693-701. Pubmed PMID:
- Chen R, Neill JD, Estes MK, Prasad BV "." Proc. Natl. Acad. Sci. U.S.A.. 2006 May 23;103(21):8048-53. Pubmed PMID:
- Citovsky V, Wong ML, Shaw AL, Prasad BV, Zambryski P "." Plant Cell. 1992 Apr;4(4):397-411. Pubmed PMID:
- Prasad BV, Prevelige PE "." Adv. Protein Chem.. 2003;64:219-58. Pubmed PMID:
- Crawford SE, Mukherjee SK, Estes MK, Lawton JA, Shaw AL, Ramig RF, Prasad BV "." J. Virol.. 2001 Jul;75(13):6052-61. Pubmed PMID:
- Criglar JM1, Hu L, Crawford SE, Hyser JM, Broughman JR, Prasad BV, Estes MK. "." J Virol. 2014 Jan;88(2):786-98. Pubmed PMID:
- Grimes JM, Jakana J, Ghosh M, Basak AK, Roy P, Chiu W, Stuart DI, Prasad BV "." Structure. 1997 Jul 15;5(7):885-93. Pubmed PMID:
- Brown NG, Chow DC, Sankaran B, Zwart P, Prasad BV, Palzkill T "." J. Biol. Chem.. 2011 Sep 16;286(37):32723-35. Pubmed PMID:
- Ajami NJ, Barry MA, Carrillo B, Muhaxhiri Z, Neill FH, Prasad BV, Opekun AR, Gilger MA, Graham DY, Atmar RL, Estes MK "." Clin. Vaccine Immunol.. 2012 Dec;19(12):1980-3. Pubmed PMID:
- Chung SH, Frese KK, Weiss RS, Prasad BV, Javier RT "." J. Virol.. 2007 May;81(9):4787-97. Pubmed PMID:
- Choi JM, Hutson AM, Estes MK, Prasad BV "." Proc. Natl. Acad. Sci. U.S.A.. 2008 Jul 8;105(27):9175-80. Pubmed PMID:
- Mathieu M, Petitpas I, Navaza J, Lepault J, Kohli E, Pothier P, Prasad BV, Cohen J, Rey FA "." EMBO J.. 2001 Apr 2;20(7):1485-97. Pubmed PMID:
- Zeng CQ, Labb茅 M, Cohen J, Prasad BV, Chen D, Ramig RF, Estes MK "." Virology. 1994 May 15;201(1):55-65. Pubmed PMID:
- Lawton JA, Estes MK, Prasad BV "." Proc. Natl. Acad. Sci. U.S.A.. 1999 May 11;96(10):5428-33. Pubmed PMID:
- Prasad BV, Chandrasekaran R "." Int. J. Pept. Protein Res.. 1977;10(2):129-38. Pubmed PMID:
- Ossiboff RJ, Zhou Y, Lightfoot PJ, Prasad BV, Parker JS "." J. Virol.. 2010 Jun;84(11):5550-64. Pubmed PMID:
- Jiang X, Jayaram H, Kumar M, Ludtke SJ, Estes MK, Prasad BV "." J. Virol.. 2006 Nov;80(21):10829-35. Pubmed PMID:
- Chen R, Neill JD, Prasad BV "." J. Struct. Biol.. 2003 Feb;141(2):143-8. Pubmed PMID:
- Hu L, Chow DC, Patton JT, Palzkill T, Estes MK, Prasad BV "." J. Virol.. 2012 Oct;86(19):10547-57. Pubmed PMID:
- Kumar M, Jayaram H, Vasquez-Del Carpio R, Jiang X, Taraporewala ZF, Jacobson RH, Patton JT, Prasad BV "." J. Virol.. 2007 Nov;81(22):12272-84. Pubmed PMID:
- Zheng B1, Yao Y, Liu Z, Deng L, Anglin JL, Jiang H, Prasad BV, Song Y. "." ACS Med Chem Lett.. 2013 Jun 13;4(6):542-546. Pubmed PMID:
- Talmon Y, Prasad BV, Clerx JP, Wang GJ, Chiu W, Hewlett MJ "." J. Virol.. 1987 Jul;61(7):2319-21. Pubmed PMID:
- Jayaram H, Estes MK, Prasad BV "." Virus Res.. 2004 Apr;101(1):67-81. Pubmed PMID:
- Prasad BV, Degn LL, Jeng TW, Chiu W "." Ultramicroscopy. 1990 Oct;33(4):281-5. Pubmed PMID:
- Chakravarty S, Hutson AM, Estes MK, Prasad BV "." J. Virol.. 2005 Jan;79(1):554-68. Pubmed PMID:
- Singh S, Rothnagel R, Prasad BV, Buckley B "." Virology. 1995 Nov 10;213(2):472-81. Pubmed PMID:
- Kallewaard NL, McKinney BA, Gu Y, Chen A, Prasad BV, Crowe JE "." J. Immunol.. 2008 Mar 15;180(6):3980-9. Pubmed PMID:
- Chung SH, Weiss RS, Frese KK, Prasad BV, Javier RT "." Oncogene. 2008 Feb 28;27(10):1412-20. Pubmed PMID:
- Monnier N, Higo-Moriguchi K, Sun ZY, Prasad BV, Taniguchi K, Dormitzer PR "." J. Virol.. 2006 Feb;80(3):1513-23. Pubmed PMID:
- Weiss RS, Lee SS, Prasad BV, Javier RT "." J. Virol.. 1997 Mar;71(3):1857-70. Pubmed PMID:
- Lawton JA, Estes MK, Prasad BV "." J. Virol.. 2001 Feb;75(4):1632-42. Pubmed PMID:
- Rahman GM, Shanker S, Lewin NE, Kedei N, Hill CS, Prasad BV, Blumberg PM, Das J "." Biochem. J.. 2013 Jul 1;453(1):153. Pubmed PMID:
- Rahman GM, Shanker S, Lewin NE, Kedei N, Hill CS, Prasad BV, Blumberg PM, Das J "." Biochem. J.. 2013 Apr 1;451(1):33-44. Pubmed PMID:
- Deng L, Diao J, Chen P, Pujari V, Yao Y, Cheng G, Crick DC, Prasad BV, Song Y "." J. Med. Chem.. 2011 Jul 14;54(13):4721-34. Pubmed PMID:
- Feng N, Lawton JA, Gilbert J, Kuklin N, Vo P, Prasad BV, Greenberg HB "." J. Clin. Invest.. 2002 May;109(9):1203-13. Pubmed PMID:
- Chen R, Neill JD, Noel JS, Hutson AM, Glass RI, Estes MK, Prasad BV "." J. Virol.. 2004 Jun;78(12):6469-79. Pubmed PMID:
- Nason EL, Rothagel R, Mukherjee SK, Kar AK, Forzan M, Prasad BV, Roy P "." J. Virol.. 2004 Aug;78(15):8059-67. Pubmed PMID:
- Prasad BV, Burns JW, Marietta E, Estes MK, Chiu W "." Nature. 1990 Feb 1;343(6257):476-9. Pubmed PMID:
- Lawton JA, Estes MK, Prasad BV "." Adv. Virus Res.. 2000;55:185-229. Pubmed PMID:
- Guevara J, Knapp RD, Spurlino J, Prasad BV, Morrisett JD "." J. Protein Chem.. 1992 Dec;11(6):653-6. Pubmed PMID:
- Horton LB1, Shanker S, Mikulski R, Brown NG, Phillips KJ, Lykissa E, Venkataram Prasad BV, Palzkill T. "." Antimicrob Agents Chemother.. 2012;56(11):5667-77. Pubmed PMID:
- Estes MK, Prasad BV, Atmar RL "." Curr. Opin. Infect. Dis.. 2006 Oct;19(5):467-74. Pubmed PMID:
- Shoemaker GK, van Duijn E, Crawford SE, Uetrecht C, Baclayon M, Roos WH, Wuite GJ, Estes MK, Prasad BV, Heck AJ "." Mol. Cell Proteomics. 2010 Aug;9(8):1742-51. Pubmed PMID:
- Vongpunsawad S1, Venkataram Prasad BV, Estes MK. "." J Virol. 2013 May;87(9):4818-25.
- Pesavento JB, Crawford SE, Roberts E, Estes MK, Prasad BV "." J. Virol.. 2005 Jul;79(13):8572-80. Pubmed PMID:
- Chiu W, Jeng TW, Degn LL, Prasad BV "." Ann. N. Y. Acad. Sci.. 1986;483:149-56. Pubmed PMID:
- Baclayon M, Shoemaker GK, Uetrecht C, Crawford SE, Estes MK, Prasad BV, Heck AJ, Wuite GJ, Roos WH "." Nano Lett.. 2011 Nov 9;11(11):4865-9. Pubmed PMID:
- Guevara J, Spurlino J, Jan AY, Yang CY, Tulinsky A, Prasad BV, Gaubatz JW, Morrisett JD "." Biophys. J.. 1993 Mar;64(3):686-700. Pubmed PMID:
- Zhou ZH, Prasad BV, Jakana J, Rixon FJ, Chiu W "." J. Mol. Biol.. 1994 Sep 30;242(4):456-69. Pubmed PMID:
- Clark KM, Wetzel JD, Gu Y, Ebert DH, McAbee SA, Stoneman EK, Baer GS, Zhu Y, Wilson GJ, Prasad BV, Dermody TS "." J. Virol.. 2006 Jan;80(2):671-81. Pubmed PMID:
- Carpio RV, Gonz谩lez-Nilo FD, Jayaram H, Spencer E, Prasad BV, Patton JT, Taraporewala ZF "." J. Biol. Chem.. 2004 Mar 12;279(11):10624-33. Pubmed PMID:
- Li Z, Baker ML, Jiang W, Estes MK, Prasad BV "." J. Virol.. 2009 Feb;83(4):1754-66. Pubmed PMID:
- Baker M, Prasad BV "." Curr. Top. Microbiol. Immunol.. 2010;343:121-48. Pubmed PMID:
- Hu L, Crawford SE, Hyser JM, Estes MK, Prasad BV "." Curr Opin Virol. 2012 Aug;2(4):380-8. Pubmed PMID:
- Jayaram H, Taraporewala Z, Patton JT, Prasad BV "." Nature. 2002 May 16;417(6886):311-5. Pubmed PMID:
- Pesavento JB, Crawford SE, Estes MK, Prasad BV "." Curr. Top. Microbiol. Immunol.. 2006;309:189-219. Pubmed PMID:
- Shaw AL, Rothnagel R, Zeng CQ, Lawton JA, Ramig RF, Estes MK, Prasad BV "." Arch. Virol. Suppl.. 1996;12:21-7. Pubmed PMID:
- Yao Y, Chen P, Diao J, Cheng G, Deng L, Anglin JL, Prasad BV, Song Y "." J. Am. Chem. Soc.. 2011 Oct 26;133(42):16746-9. Pubmed PMID:
- Prasad BV, Chiu W "." J. Mol. Biol.. 1987 Feb 5;193(3):579-84. Pubmed PMID:
- Shanker S1, Czako R, Sankaran B, Atmar RL, Estes MK, Prasad BV. "." J. Virol.. 2014 Mar 19; Pubmed PMID:
- Brown NG, Shanker S, Prasad BV, Palzkill T "." J. Biol. Chem.. 2009 Nov 27;284(48):33703-12. Pubmed PMID:
- Shanker, S., Czak贸, R., Sapparapu, G., Alvarado, G., Viskovska, M., Sankaran, B., Atmar, R.L., Crowe, J.E. Jr., Estes, M.K., Prasad, B.V.V. "." Proc Natl Acad Sci U S A.. 2016;113:E5830-E5837. Pubmed PMID:
- Hu, L., Ramani, S., Czako, R., Sankaran, B., Yu, Y, Smith, D.F., Cummings, R.D., Estes, M.K. and Prasad, B.V.V. "." Nature Communications. 2015;6:8346. Pubmed PMID:
- Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y, Prasad BV "." J. Virol.. 2013 Apr;87(8):4281-92. Pubmed PMID:
- Paredes AM, Heidner H, Thuman-Commike P, Prasad BV, Johnston RE, Chiu W "." J. Virol.. 1998 Feb;72(2):1534-41. Pubmed PMID:
- Dormitzer PR, Nason EB, Prasad BV, Harrison SC "." Nature. 2004 Aug 26;430(7003):1053-8. Pubmed PMID:
- Bertolotti-Ciarlet A, White LJ, Chen R, Prasad BV, Estes MK "." J. Virol.. 2002 Apr;76(8):4044-55. Pubmed PMID:
- Schmid MF, Prasad BV, Chiu W "." Arch. Virol. Suppl.. 1994;9:523-9. Pubmed PMID:
- Prasad BV, Crawford S, Lawton JA, Pesavento J, Hardy M, Estes MK "." Novartis Found. Symp.. 2001;238:26-37; discussi. Pubmed PMID:
- Prasad BV, Hardy ME, Jiang X, Estes MK "." Arch. Virol. Suppl.. 1996;12:237-42. Pubmed PMID:
- Prasad BV, Chiu W "." Curr. Top. Microbiol. Immunol.. 1994;185:41546. Pubmed PMID:
- Taraporewala ZF, Jiang X, Vasquez-Del Carpio R, Jayaram H, Prasad BV, Patton JT "." J. Virol.. 2006 Aug;80(16):7984-94. Pubmed PMID:
- Pesavento JB, Billingsley AM, Roberts EJ, Ramig RF, Prasad BV "." J. Virol.. 2003 Mar;77(5):3291-6. Pubmed PMID:
- Deng L1, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song Y. "." Medchemcomm. 2013;4(10) Pubmed PMID:
- Chiu W, Schmid MF, Prasad BV "." Biophys. J.. 1993 May;64(5):1610-25. Pubmed PMID:
- Carrillo B1, Choi JM, Bornholdt ZA, Sankaran B, Rice AP, Prasad BV. "." J Virol. 2014 Apr;88(8):4113-22. Pubmed PMID:
- Prasad BV, Balaram P "." CRC Crit. Rev. Biochem.. 1984;16(4):307-48. Pubmed PMID:
- Hill CL, Booth TF, Prasad BV, Grimes JM, Mertens PP, Sutton GC, Stuart DI "." Nat. Struct. Biol.. 1999 Jun;6(6):565-8. Pubmed PMID:
- Shaw AL, Samal SK, Subramanian K, Prasad BV "." Structure. 1996 Aug 15;4(8):957-67. Pubmed PMID:
- Ramani S, Cortes-Penfield NW, Hu L, Crawford SE, Czako R, Smith DF, Kang G, Ramig RF, Le Pendu J, Prasad BV, Estes MK "." J. Virol.. 2013 Jul;87(13):7255-64. Pubmed PMID:
- Ramani S1, Cortes-Penfield NW, Hu L, Crawford SE, Czako R, Smith DF, Kang G, Ramig RF, Le Pendu J, Prasad BV, Estes MK. "." J Virol. 2013 Jul;87(13):7255-64. Pubmed PMID:
- Lawton JA, Zeng CQ, Mukherjee SK, Cohen J, Estes MK, Prasad BV "." J. Virol.. 1997 Oct;71(10):7353-60. Pubmed PMID:
- Paredes AM, Brown DT, Rothnagel R, Chiu W, Schoepp RJ, Johnston RE, Prasad BV "." Proc. Natl. Acad. Sci. U.S.A.. 1993 Oct 1;90(19):9095-9. Pubmed PMID:
- Prasad BV, Rothnagel R, Jiang X, Estes MK "." J. Virol.. 1994 Aug;68(8):5117-25. Pubmed PMID:
- Prasad BV, Matson DO, Smith AW "." J. Mol. Biol.. 1994 Jul 15;240(3):256-64. Pubmed PMID:
- Prasad BV, Wang GJ, Clerx JP, Chiu W "." J. Mol. Biol.. 1988 Jan 20;199(2):269-75. Pubmed PMID:
- Thuman-Commike PA, Greene B, Jakana J, Prasad BV, King J, Prevelige PE, Chiu W "." J. Mol. Biol.. 1996 Jul 5;260(1):85-98. Pubmed PMID:
- Prasad BV, Yamaguchi S, Roy P "." J. Virol.. 1992 Apr;66(4):2135-42. Pubmed PMID:
- Schrag JD, Prasad BV, Rixon FJ, Chiu W "." Cell. 1989 Feb 24;56(4):651-60. Pubmed PMID:
- Prasad BV, Prevelige PE, Marietta E, Chen RO, Thomas D, King J, Chiu W "." J. Mol. Biol.. 1993 May 5;231(1):65-74. Pubmed PMID:
Memberships
- American Crystallographic Association
- Member (01/2014)
- American Society of Virology
- Member (01/2014)
- Biophysical Society of America
- Member (01/2014)
- American Society of Microbiology
- Member (01/2014)
- American Association for the Advancement of Science
Skills
- X-ray Crystallography
- Cryo-EM
- Computational Biology
- Cell culture
- Protein Purification
- Biophysical Chemistry
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