Participants needed for atypical diabetes study
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草榴社区入口 is recruiting volunteers, particularly from historically underrepresented populations, who believe they may have an atypical form of diabetes to participate in the Rare and Atypical Diabetes Network (RADIANT) study. This study discovers and classifies new and unusual forms of diabetes based on the experience of people diagnosed with diabetes who have had difficulty in managing the disease or responding to treatment based on their type 1 or 2 diagnoses.
鈥淒iabetes has always been classified as type 1 or type 2. This is an oversimplified and increasingly unhelpful way to classify a very complex disease,鈥 said Dr. Ashok Balasubramanyam, professor of endocrinology, diabetes and metabolism at Baylor and principal investigator and director of the Baylor site. 鈥淲e estimate that 10-15% of people diagnosed with diabetes have atypical diabetes.鈥
Common symptoms of atypical diabetes include very early onset diabetes, being an underweight adult with diabetes, being obese at a young age or having many members in a family develop diabetes in childhood or adolescence.
Interested participants will receive blood testing and answer questions about family and medical history to determine eligibility. If selected, participants will receive genetic testing, a comprehensive in-person visit including a detailed physical exam, and evaluation of their genetic results from genetics and diabetes experts to determine the cause of their unique type of diabetes. All testing is free, and participants may receive compensation for their time.
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So far, almost 900 people have volunteered to participate in the RADIANT study. The team hopes to recruit at least 1,500 people and is eager to recruit members from minority and immigrant populations.
鈥淲e anticipate that many atypical forms of diabetes are highly represented in minority and immigrant populations. We are also looking for rare types of diabetes due to specific genetic defects, because we now have the tools to both identify and possibly treat them with precision medicine,鈥 Balasubramanyam said.
For more information and to complete a screening questionnaire, visit or contact radiantstudy@bcm.edu or 713-798-5757.
RADIANT was launched on Sept. 30, 2020. Baylor and the University of Chicago will serve as the lead centers for the study. Baylor and the Broad Institute in Cambridge, Mass., serve as the RNA and DNA sequencing centers. The University of South Florida is the data coordinating center for the study, and the University of Florida - Gainesville, serves as the central laboratory.
Other clinical sites participating in RADIANT include University of Chicago, Columbia University, Duke University, Geisinger Health System, Indiana University, University of Colorado 鈥 Denver, University of Maryland, Massachusetts General Hospital, University of Michigan, NorthShore University Health System, Seattle Children鈥檚 Hospital, SUNY Downstate Health Sciences University, University of North Carolina, University of Washington, Vanderbilt University and Washington University-St. Louis.
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Se necesitan participantes para estudio de diabetes at铆pica
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草榴社区入口 est谩 reclutando personas voluntarias, particularmente de poblaciones hist贸ricamente subrepresentadas, que creen que puedan tener una forma at铆pica de diabetes para que participen en el estudio Red de Diabetes Rara y At铆pica (Rare and Atypical Diabetes Network (RADIANT) study, en ingl茅s). El objetivo de este estudio es descubrir y clasificar formas poco comunes de diabetes en base a las experiencias de personas diagnosticadas con diabetes que tienen dificultad manejando la enfermedad o respondiendo a tratamiento basado en su diagnosis de diabetes de tipo 1 o 2.
鈥淟a diabetes siempre se ha clasificado como tipo 1 o 2. Esto simplifica demasiado y es cada vez menos 煤til para clasificar una enfermedad tan compleja,鈥 dijo el Dr. Ashok Balasubramanyam, profesor de endocrinolog铆a, diabetes y metabolismo en Baylor e investigador principal y director de en Baylor. 鈥淣osotros estimamos que entre 10% y 15% de las personas diagnosticadas con diabetes tienen diabetes at铆pica.鈥
S铆ntomas comunes de la diabetes at铆pica incluyen inicio de la enfermedad muy temprano, ser un adulto con bajo peso, ser obeso a edad temprana o tener muchos miembros en la familia que desarrollan diabetes en la infancia o adolescencia.
A los participantes interesados se les har谩n pruebas de sangre y preguntas acerca de su familia e historia m茅dica para determinar su elegibilidad. Si son seleccionados, los participantes recibir谩n pruebas gen茅ticas, una visita completa en persona que incluye in examen f铆sico detallado, y evaluaci贸n de sus resultados gen茅ticos por expertos en gen茅tica y diabetes para determinar la causa de su tipo 煤nico de diabetes. Todas las pruebas son gratis y los participantes pueden recibir compensaci贸n por su tiempo.
Hasta ahora, casi 900 personas est谩n participando en forma voluntaria en el estudio RADIANT. Los investigadores esperan reclutar al menos 1.500 personas y est谩n deseosos de reclutar miembros de poblaciones minoritarias e inmigrantes.
鈥淣osotros anticipamos que muchas formas at铆picas de diabetes est谩n altamente representadas en poblaciones minoritarias e inmigrantes. Tambi茅n estamos buscando formas raras de diabetes debidas a defectos gen茅ticos espec铆ficos, porque ahora tenemos los medios para tanto identificarlas como posiblemente tratarlas con medicina de precisi贸n,鈥 dijo Balasubramanyam.
Para m谩s informaci贸n y para completar el cuestionario de selecci贸n, visite o contacte radiantstudy@bcm.edu o llame al 713-798-5757.
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RADIANT fue lanzado el 30 de septiembre de 2020. Baylor y la Universidad de Chicago sirven como los centros l铆deres del Proyecto. Baylor y el Instituto Broad en Cambridge, Mass., sirven como centros de secuenciaci贸n de RNA y DNA. La Universidad del Sur de Florida es el centro de coordinaci贸n de datos para el estudio y la Universidad de Florida 鈥 Gainesville sirve de laboratorio central.
Otros centros cl铆nicos que tambi茅n participant en RADIANT incluyen University of Chicago, Columbia University, Duke University, Geisinger Health System, Indiana University, University of Colorado 鈥 Denver, University of Maryland, Massachusetts General Hospital, University of Michigan, NorthShore University Health System, Seattle Children鈥檚 Hospital, SUNY Downstate Health Sciences University, University of North Carolina, University of Washington, Vanderbilt University and Washington University-St. Louis.