Zheng Sun, Ph.D.
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Zheng Sun, Ph.D.
Associate Professor
Positions
- Associate Professor
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Department of Medicine, Division of Endocrinology, Diabetes and Metabolism
Department of Molecular and Cellular Biology
草榴社区入口
- Member
-
Dan L Duncan Comprehensive Cancer Center
草榴社区入口
Houston, Texas United States
- Member
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Gulf Coast Center for Precision Environmental Health
草榴社区入口
Houston, Texas United States
- Member
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Huffington Center on Aging
草榴社区入口
Houston, Texas United States
- Member
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Texas Medical Center Digestive Diseases Center
草榴社区入口
Houston, Texas United States
Addresses
- Alkek Building for Biomedical Research (Office)
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Room: ABBR-R616
Houston, TX 77030
United States
Phone: (713) 798-3164
/research/labs/zheng-sun
Education
- PhD from University of Arizona
- Tucson
- Post-Doctoral Fellowship at University of Pennsylvania
- Philadelphia
Professional Interests
- Epigenomic regulation of energy metabolism and neurocognition by physical exercise, diet, endocrine factors, and the circadian clock.
Professional Statement
What doesn't kill you makes you stronger. Hormesis, the paradoxical beneficial effect of low-dose stressors, can be elicited by reactive oxygen species, chemical toxins, calorie restriction, and physical exercise. Timing is everything in resilience. Intermittent exposure can generate opposite effects compared with continuous exposure. Early-life stress can increase resilience in later life and lack of stress can lead to vulnerability. An initial exposure can elicit an adaptive stress response with long-term epigenomic changes that anticipate subsequent exposures.We are interested in how energy metabolism and neurocognition are regulated at the epigenomic level by the environmental factors including diet, physical exercise, hormones, and the circadian clock. We apply multi-omics approaches, optogenetics, chemogenetics, single-cell techniques, genome editing, novel viral vectors, metabolic tracing, neuronal tracing, and neurobehavioral tests.
Keywords: circadian clock, epigenome, nuclear hormone receptor, diabetes, heart failure, autism, neurodegenerative disease
Websites
Selected Publications
- Peng F, Li X, Xiao F, Zhao R, Sun Z. "Circadian clock, diurnal glucose metabolic rhythm, and dawn phenomenon." Trends Neurosci.. 2022;45(6):471-482.
- Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q, Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J, Zhang L, Sun Z. "." Circulation. 2022;145(6):448-464. Pubmed PMID:
- Ding G, Li X, Hou X, Zhou W, Gong Y, Liu F, He Y, Song J, Wang J, Basil P, Li W, Qian S, Saha P, Wang J, Cui C, Yang T, Zou K, Han Y, Amos CI, Xu Y, Chen L, Sun Z. "Rev-erb in GABAergic neurons controls diurnal hepatic insulin sensitivity." Nature. 2021;592(7856):763-767.
- Gong Y, Xue Y, Li X, Zhang Z, Zhou W, Marcolongo P, Benedetti A, Mao S, Han L, Ding G, Sun Z. "Inter- and trans-generational effects of paternal exposure to inorganic arsenic." Adv. Sci. 2021;8(7):2002715.
- Kong Y, Zhou W, Sun Z "." Mol Psychiatry. 2020;161(8):bqaa083. Pubmed PMID:
- Zhou W, He Y, Rehman AU, Kong Y, Hong Y, Ding G, Yalamanchili HK, Wan Y-W, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O鈥橠riscoll M, Morton JEV, DDD study, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z "." Nat Neurosci. 2019;22(2):205-217. Pubmed PMID:
- Li X, Yang T, Sun Z. "." Trends Endocrinol Metab. 2019;(19)30174-2 Pubmed PMID:
- Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z "." Nat Med. 2017;23(2):223-234. Pubmed PMID:
- Zhang Y, Fang B, Emmett MJ, Damle M, Sun Z, Feng D, Armour SM, Remsberg JR, Jager J, Soccio RE, Steger DJ, Lazar MA "." Science. 2015;348(6242):1488-92. Pubmed PMID:
- Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA "." Cell Metab. 2016;24(6):863-874. Pubmed PMID:
- Fang B, Everett LJ, Jager J, Briggs E, Armour SM, Feng D, Roy A, Gerhart-Hines Z, Sun Z, Lazar MA. "." Cell. 2014;159(5):1140-52. Pubmed PMID:
- Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA "." Mol Cell. 2013;52(6):769-82. Pubmed PMID:
- Sun Z, Lazar MA "." Trends Endocrinol Metab. 2013;24(1):4-12. Pubmed PMID:
- Sun Z, Feng D, Everett LJ, Bugge A, Lazar MA "." Cold Spring Harb Symp Quant Biol. 2011;76:49-55. Pubmed PMID:
- Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Liu XS, Lazar MA "." Science. 2011;331(6022):1315-9. Pubmed PMID:
- Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA "." Nat Med. 2012;18(6):934-42. Pubmed PMID:
- You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA "." Nat Struct Mol Biol. 2013;20(2):182-7. Pubmed PMID:
- Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA "." J Biol Chem. 2011;286(38):33301-9. Pubmed PMID:
- Sun Z, Wu T, Birch CM, Zhang DD "." Mol Cell Biol. 2011;31(9):1800-11. Pubmed PMID:
- Sun Z, Chin YE, Zhang DD "." Mol Cell Biol. 2009;29:2658-72. Pubmed PMID:
- Sun Z, Zhang S, Chan JY, Zhang DD "." Mol Cell Biol. 2007;27:6334-49. Pubmed PMID:
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