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Email

goodell@bcm.edu

Positions

Professor and Chair

Molecular and Cellular Biology
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Houston, Texas United States

Vivian L. Smith Chair in Regenerative Medicine

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Houston, Texas United States

Director

Stem Cells and Regenerative Medicine Center (STaR)
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Houston, Texas United States

Member

Center for Cell and Gene Therapy (CAGT)
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Houston, Texas United States

Co-Leader, Cancer Cell and Gene Therapy

Dan L. Duncan Comprehensive Cancer Center
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Houston, Texas United States

Addresses

²ÝÁñÉçÇøÈë¿Ú (Office)

1 Baylor Plaza
BCM130
Houston, TX 77030
United States
Phone: (713) 798-6037

²ÝÁñÉçÇøÈë¿Ú (Office)

Assistant: Pon Vongsombath
Houston, TX 77030
United States
Phone: (713) 798-6037
pon.vongsombath@bcm.edu

Education

BS from Imperial College, United Kingdom

01/1986 - London, United Kingdom

PhD from University of Cambridge

01/1991 - Cambridge, United Kingdom

Postdoctoral Fellowship at Whitehead Institute, M.I.T.

01/1996 - Cambridge, Massachusetts United States

Postdoctoral Fellowship at Harvard Medical School

01/1997 - Boston, Massachusetts United States

Professional Interests

• Murine and human hematopoietic stem cells
• Genetic and epigenetic regulation and development

Professional Statement

Murine and human hematopoietic stem cells; genetic and epigenetic regulation and development.
We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.

Websites

Selected Publications

• Tovy A,Rosas C,Gaikwad AS,Medrano G,Zhang L,Reyes JM,Huang YH,Arakawa T,Kurtz, K,Conneely SE,Guzman AG,Aguilar R,Gao A,Chen CW,Kim JJ,Carter MT,Lasa-Aranzasti A,Valenzuela I,Van Maldergem L,Brunetti L,Hicks MJ,Marcogliese AN,Goodell MA and RE Rau "." Haematologica. 2021 Jun 3;Online ahead of print. Pubmed PMID:
• Huang YH,Chen CW,Sundaramurthy V,SÅ‚abicki M,Hao D,Watson CJ,Tovy A,Reyes JM,Dakhova O, Crovetti BR,Galonska C,Lee M,Brunetti L,Zhou Y,Tatton-Brown K,Huang Y,Cheng X,Meissner A, Valk PJ,Van Maldergem L,Sanders MA,Blundell JR,Li W,Ebert BL,MA Goodell "." Cancer Discovery. 2021 Aug 24;Online ahead of print. Pubmed PMID:
• Zhang, X, Jeong, M, Huang, X, Wang, XQ, Wang, X, Zhou, W, Shamim, MS, Gore, H, Himadewi, P, Liu, Y, Bochkov, ID, Reyes, J, Doty, M, Huang, YH, Jung, H, Heikamp, E, Presser Aiden, A, Li, W, Su, J, Lieberman Aiden, E and MA Goodell "." Molecular Cell. 2020 May 7;78(3):506-521. Pubmed PMID:
• Hsu, JI, Dayaram, T, Tovy, A, De Braekeleer, ED, Jeong, M, Wang, F, Zhang, J, Garcia-Manero, G, Kantarjian, H, Vassiliou, G, Futreal, PA, Donehower, LA, Takahashi, K and MA Goodell "." Cell Stem Cell. 2018 Nov 1;23(5):700-713. Pubmed PMID: