Positions
- Associate Professor
-
Pediatrics-Nutrition, Medicine, Molecular Physiology & Biophysics
²ÝÁñÉçÇøÈë¿Ú
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
²ÝÁñÉçÇøÈë¿Ú
Houston, Texas United States
- Associate Professor
-
Children's Nutrition Research Center
Houston, Texas United States
- Associate Professor
-
Medicine
Diabetes and Endocrinology
BAYLOR COLLEGE OF MEDICINE
Houston, Texas United States
- Associate Professor
-
Molecular Physiology & Biophysics
BAYLOR COLLEGE OF MEDICINE
Houston, Texas United States
Education
- PhD from Ohio State University
- 06/1997 - Columbus, OH United States
- BS from University Of Science and Technology of China
- 06/1987 - Hefei, Anhui China
- MS from Shanghai Institute Of Cell Biology, Chinese Academy of Science
- 06/1990 - Shanghai, Shanghai China
- Post-Doctoral Fellowship at Harvard School of Public Health
- 10/2002 - Boston, Massachusetts United States
Professional Interests
- Molecular mechanism of life span extension by caloric restriction
- Adipose formation and function during obesity and diabetes
- Muscle, heart and liver metabolism
Professional Statement
The main focus of our research is to study the molecular mechanism of caloric restriction, which extends animal life span and reduces the onset of obesity, diabetes, cancer, neurodegeneration and cardiovascular diseases. The study of the molecular mechanism of caloric restriction may lead to pharmaceutical treatments that may mimic caloric restriction’s beneficial effects. Sir2 gene, which encodes a NAD+-dependent protein deacetylase, was reported to mediate the effect of caloric restriction in yeast. We have demonstrated that the expressions of two of the seven mammalian Sir2 homologues, SIRT2 and SIRT3, are up-regulated in response to dietary restriction, cold exposure and oxidative stress. We have illustrated the molecular mechanism of SIRT2’s action in oxidative stress resistance and the inhibition of adipocyte formation. We have also shown how SIRT3 activates adaptive thermogenesis program in brown adipose tissue and how SIRT3 regulates glucose disposal and fat oxidation in skeletal muscle. To understand the underlying molecular mechanisms, we have identified several substrate proteins for SIRT2 and SIRT3. Research is under way to investigate the actions of sirtuins in gain or loss-of-function animal models.Another research direction we take is to study the development of adipose tissue and its changes during obesity. By investigating how mature adipocytes are derived from multi-potent precursor cells, we can gain insight into obesity prevention. In addition, by studying how factors produced by adipocytes and adipose tissue influence whole body metabolism, we may learn how obesity causes insulin resistance and subsequent type-2 diabetes. We have revealed that the expression of the PU.1 transcription factor is increased by obesity in visceral but not subcutaneous adipose tissues. We further found that in adipocytes, PU.1 up-regulates the generation of free radicals and pro-inflammatory cytokines to suppress insulin signaling. We are currently exploring the possibility to ameliorate obesity-associated metabolic dysfunction by targeting the PU.1 pathway.
Websites
Selected Publications
- Mukherjee S, Mo J, Paolella LM, Perry CE, Toth J, Hugo MM, Chu Q, Tong Q, Chellappa K, Baur JA "." JCI Insight. 2021 Apr 8;6(7):e147193. Pubmed PMID:
- Liu Z, Liu H, He J, Lin P, Tong Q, Yang J "." Sci Signal. 2020 May 26;13(633):eaay8203. Pubmed PMID:
- Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, Sun K "." FASEB J.. 2020 Jun;34(6):8265-8282. Pubmed PMID:
- Zhang T, Liu J, Shen S, Tong Q, Ma X, Lin L "." Cell Death Differ. 2020 Jan;27(1):329-344. Pubmed PMID:
- Zhang T, Liu J, Tong Q, Lin L "." Int J Mol Sci. 2020 Jan 7;21(2):372. Pubmed PMID:
- Liu H, He J, Koh SP, Zhong Y, Liu Z, Wang Z, Zang Y, Li Z, Tam BT, Lin P, Xiao M, Young kH, Amini B, Starbuck MW, Lee HC, Navone NM, Davis RE, Tong Q, Bergsagel PL, Hou J, Yi Q, Orlowski RZ, Gagel RF, Yang J. "." Sci Transl Med. 2019 May 29;11(494):eaaau9087. Pubmed PMID:
- Sebaa R, Johnson J, Pileggi C, Norgren M, Xuan J, Sai Y, Tong Q, Krystkowiak I, Bondy-Chorney E, Davey NE, Krogan N, Downey M, Harper ME "." Mol Metab. 2019 Jul;25:35-49. Pubmed PMID:
- Cao J, Yu Y, Zhang Z, Chen X, Hu Z, Tong Q, Chang J, Feng XH, Lin X "." Diabetes. 2018 Jan;67(1):46-57. Pubmed PMID:
- Liu JX, Shen SN, Tong Q, Wang YT, Lin LG "." Eur J Pharmacol. 2018 Sep 5;5(834):176-187. Pubmed PMID:
- Li Q, Lei F, Tang Y, Pan JS, Tong Q, Sun Y, Sheikh-Hamad D "." Cell Mol Life Sci. 2018 Nov;75(21):4021-4040. Pubmed PMID:
- Liu J, Li D, Zhang T, Tong Q, Ye RD, Lin L "." Cell Death Dis. 2017 Oct; Pubmed PMID:
- de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, (…), Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF "." PLoS Biol. 2017 Mar 3;15(3):e2000374. Pubmed PMID:
- Rubel CA, Wu SP, Lin L, Wang T, Lanz RB, Li X, Kommagani R, Franco HL, Camper SA, Tong Q, Jeong JW, Lydon JP, DeMayo FJ "." Cell Rep. 2016 Oct 25;17(5):1414-1425. Pubmed PMID:
- Liu Z, Xu J, He J, Liu H, Lin P, Wan X, Navone NM, Tong Q, Kwak LW, Orlowski RZ, Yang J "." Oncotarget. 2015 Oct 27;6(33):34329-41. Pubmed PMID:
- Nosavanh L, Yu DH, Jaehnig EJ, Tong Q, Shen L, Chen MH "." Proc Natl Acad Sci USA. 2015 Apr 21;112(16):5069-74. Pubmed PMID:
- Cheung KG, Cole LK, Xiang B, Chen K, Ma X, Myal Y, Hatch GM, Tong Q, Dolinsky VW "." J Biol Chem. 2015 Apr 24;290:10981-10993. Pubmed PMID:
- Pan J S-C, Huang L, Belousova T, Lu L, Yang Y, Reddel R, Chang A, Ju H, DiMattia G, Tong Q, Sheikh-Hamad D. "." J Am Soc Nephrol. 2015 Feb;26(2):364-78. Pubmed PMID:
- Ligen Lin, Keyun Chen, Waed Abdel Khalek, Jack Lee Ward III, Henry Yang, Béatrice Chabi, Chantal Wrutniak-Cabello, Qiang Tong "." PLOS One. 2014;9(1):e85636. Pubmed PMID:
- Serrano L, MartÃnez-Redondo P, Marazuela-Duque A, Vazquez BN, Dooley SJ, Voigt P, Beck DB, Kane-Goldsmith N, Tong Q, Rabanal RM, Fondevila D, Muñoz P, Krüger M, Tischfield JA, Vaquero A. "." Genes & Development. 2013;27(6):639-653. Pubmed PMID:
- Wang F, Chan CH, Chen K, Guan X, Lin HK, Tong Q "." Oncogene. 2012 Mar 22;31(12):1546-57. Pubmed PMID:
- Lin L, Pang W, Chen K, Wang F, Gengler J, Sun Y, Tong Q "." Am. J. Physiol. Endocrinol. Metab.. 2012 Jun;302(12):E1550-9. Pubmed PMID:
- Yang Y, Chen KY, Tong Q "." Gene. 2011 Nov 15;488(41276):46-51. Pubmed PMID:
- Lin L, Saha PK, Ma X, Henshaw IO, Shao L, Chang BH, Buras ED, Tong Q, Chan L, McGuinness OP, Sun Y "." Aging Cell. 2011 Dec;10(6):996-1010. Pubmed PMID:
- Yang Y, Hubbard BP, Sinclair DA, Tong Q "." J. Cell. Biochem.. 2010 Nov 1;111(4):1051-8. Pubmed PMID:
- Gao X, Shin YH, Li M, Wang F, Tong Q, Zhang P "." PLoS ONE. 2010;5(11):e14005. Pubmed PMID:
- Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC "." J. Biol. Chem.. 2010 Mar 5;285(10):7417-29. Pubmed PMID:
- Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL, Goodyear LJ, Tong Q "." Aging (Albany NY). 2009 Sep;1(9):771-83. Pubmed PMID:
- Wang F, Tong Q "." Mol. Biol. Cell. 2009 Feb;20(3):801-8. Pubmed PMID:
- Julia Skokowa, Dan Lan, Basant Kumar Thakur, Fei Wang, Kshama Gupta, Gunnar Cario, Annette Muller Brechlin, Axel Schambach, Lars Hinrichsen, Gustav Meyer, Matthias Gaestel, Martin Stanulla, Qiang Tong and Karl Welte "." Nat Med. 2009 Feb;15(2):151-158. Pubmed PMID:
- Wang F, Tong Q "." Am. J. Physiol., Cell Physiol.. 2008 Jul;295(1):C213-20. Pubmed PMID:
- Wang F, Nguyen M, Qin FX, Tong Q "." Aging Cell. 2007 Aug;6(4):505-14. Pubmed PMID:
- Qiang Tong, Judy Tsai, Guo Tan, Gökhan Dalgin, and Gökhan S. Hotamisligil "." Mol Cell Biol. 2005 Jan;25(2):706-715. Pubmed PMID:
- Tong Shi, Fei Wang, Emily Stieren, and Qiang Tong "." J Biol Chem. 2005 Apr;280(14):13560-13567. Pubmed PMID:
- Tong Q, Tsai J, Hotamisligil GS "." Drug News Perspect.. 2003 Nov;16(9):585-8. Pubmed PMID:
- Qiang Tong, Gökhan Dalgin, Haiyan Xu, Chao-Nan Ting, Jeffrey M. Leiden and Gökhan S. Hotamisligil "." Science. 2000 Oct;290:134-138. Pubmed PMID:
to edit your profile
