Kian Peng Koh, Ph.D.
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Kian Peng Koh, Ph.D.
Associate Professor
Positions
- Associate Professor
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Molecular and Cellular Biology
Ctr for Precision Environmental Health
草榴社区入口
Education
- BA from Williams College
- 06/1999 - Williamstown, Massachusetts United States
- Biology, Chemistry
- PhD from Yale University
- 12/2004 - New Haven, Connecticut United States
- Pharmacology
- Postdoctoral Training at Harvard Medical School
- 08/2011 - Boston, Massachusetts United States
Professional Statement
Early life exposures to environmental insults have a profound impact on health across the course of life, ranging from birth defects to increased susceptibility to diseases such as cancer, cardiovascular and metabolic disease in adulthood. The epigenome is an important target of these exposures, as it functions as a highly dynamic interface between the genome and the environment. However, the epigenome-genome-environment (ExGxE) interactions that together determine how environmental exposures impact the developing epigenome to adversely affect health remain largely uncharted.The Jumonji family of DNA and histone demethylases, as iron (II)- and alpha-ketoglutarate-dependent dioxygenases, are potentially epigenetic rheostats that integrate environmental inputs with the genome and epigenome to regulate pre-natal development. In particular, the Tet-Eleven-Translocation (TET) DNA dioxygenases erase DNA methylation by reiterative oxidation of 5-methylcytosine via 5-hydroxymethylcytosine. Our current studies examine the nuanced and long-term developmental impact of DNA demethylation mediated by TET1, as well as its non-catalytic functions, during early embryonic differentiation using mouse models. We also leverage on complementary genomic and epigenomic approaches to elucidate how genetic variants and nutritional stressors interact with TET1 and other dioxygenases in the etiologies of congenital malformations including neural tube defects.
Selected Publications
- Chen L, van der Veer BK, Chen Q, Champeris Tsaniras S, Brangers W, Kwak HHM, Khoueiry R, Lei Y, Cabrera R, Gross SS, Finnell RH, Koh KP. "." EMBO Rep.. 2024 Nov 22; Pubmed PMID:
- van der Veer BK, Chen L, Custers C, Athanasouli P, Schroiff M, Cornelis R, Chui JS, Finnell RH, Lluis F, Koh KP. "." Nucleic Acids Res .. 2023 Apr 6; Pubmed PMID:
- Luo X, van der Veer BK, Sun L, Bartoccetti M, Boretto M, Vankelecom H, Khoueiry R. Koh, KP "." Genes & Dev. 2020;34(7-8):598-618. Pubmed PMID:
- Bartoccetti M, van der Veer BK, Luo X, Khoueiry R, She P, Bajaj M, Xu J, Janiszewski A, Thienpont B, Pasque V and Koh KP "." Cell Rep. 2020;30(7):2150-2169. Pubmed PMID:
- Khoueiry R, Sohni, A., Thienpont, B., Luo, X.L., Vande Velde, J., Bartoccetti, M., Boeck, B., Zwijsen, A., Rao, A., Lambrechts, D, Koh, KP "." Nat Genet. 2017;49(7):1061-1072. Pubmed PMID:
- Sohni A, Bartoccetti M, Khoueiry R, Spans L, Vande Velde J, De Troyer L, Pulakanti K, Claessens F, Rao S, Koh KP "." Mol Cell Biol. 2015;35(6):1026-1042. Pubmed PMID:
- Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A "." Cell Stem Cell. 2011;8(2):200-213. Pubmed PMID:
- Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A "." Science. 2009;324(5929):930-935. Pubmed PMID:
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