Anthony Zoghbi, M.D.
Picture
Anthony Zoghbi, M.D.
Assistant Professor
Positions
- Assistant Professor
-
Molecular and Human Genetics
草榴社区入口
- Beth K. And Stuart C. Yudofsky Scholar
-
Menninger Department of Psychiatry and Behavioral Sciences
草榴社区入口
- Assistant Professor
-
Menninger Department of Psychiatry and Behavioral Sciences
草榴社区入口
- Chief
-
Menninger Department of Psychiatry and Behavioral Sciences
Psychiatric Genetics
草榴社区入口
Professional Statement
The primary goal of my lab is to understand the genomic basis of neuropsychiatric disease and translate those insights into improvements in clinical care, disease risk prediction and novel therapeutic development. Specifically, we use novel phenotyping strategies such as extreme phenotype sampling combined with whole genome sequencing and cutting-edge bioinformatics tools to improve the ability to identify genetic causes of disease. Our work is currently focused on studying rare genetic variation in severe forms of schizophrenia and obsessive-compulsive disorder, though we intend to apply similar strategies across neuropsychiatric disorders.In addition to our interest in rare variation, we are also exploring the interplay between common polygenic risk and rare variants, structural variation and pharmacogenetics in extreme phenotypes. Through this second area of interest, we aim to better understand the genomic architecture of psychiatric disorders and use genomic data in combination with environmental risk factors to predict those who will be at highest risk for developing a given disease.
The long-term goal of our research is to usher in the clinical implementation of genomics in psychiatry. We envision that this will involve a combination of genomic disease risk stratification for improved biomarker identification and targeted clinical trials, elucidating genetic predictors of treatment resistance and identifying novel genetic targets for therapeutic development.
Selected Publications
- Dhindsa RS, Zoghbi AW, Krizay DK, Vasavda C, Goldstein DB "." Ann. Neurol.. 2021 Feb;89:199-211. Pubmed PMID:
- Halvorsen, M, Samuels J, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, Geller DA, Knowles JA, Zoghbi AW, Grados M, Riddle MA, Bienvenu OJ, Nestadt PJ, Krasnow J, Goes FS, Maher B, Nestadt G, Goldstein DB "." Nat. Neurosci.. 2021 Aug;24:1071-1076. Pubmed PMID:
- Zoghbi AW, Bernanke JA, Gleichman J, Masucci MD, Corcoran CM, Califano A, Segovia J, Colibazzi T, First MB, Brucato G, Girgis RR "." J Psychiatr Res.. 2019 Jul;114:88-92. Pubmed PMID:
- Zoghbi AW, Lieberman JA "." Psychol Med.. 2018 Jan;48:245-246. Pubmed PMID:
- Girgis RR, Zoghbi AW, Javitt DC, Lieberman JA. "." J Psychiatr Res.. 2019 Jan;108:57-83. Pubmed PMID:
- Zoghbi AW, Al Jurdi RK, Deshmukh PR, Chen DC, Xiu MH, Tan YL, Yang FD, Zhang XY "." Psychiatry Res.. 2014 Dec 15;220:188-92. Pubmed PMID:
- Tsuda H, Han SM, Yang Y, Tong C, Lin YQ, Mohan K, Haueter C, Zoghbi A, Harati Y, Kwan J, Miller MA, Bellen HJ "." Cell. 2008 Jun;133:963-77. Pubmed PMID:
- Zhang J, Zhang X, Su H, Tao J, Xie Y, Han B, Lu Y, Wei Y, Sun H, Wang Y, Wu W, Zou S, Liang H, Zoghbi AW, Tang W, He J "." Neurosci Lett. 2014 Jun;571:61-5. Pubmed PMID:
- Zhang XY, Al Jurdi RK, Zoghbi AW, Chen DC, Xiu MH, Tan YL, Yang FD, Kosten TR "." J Psychiatr Res.. 2013 Oct;47:1370-5. Pubmed PMID:
to edit your profile
